Matches in SemOpenAlex for { <https://semopenalex.org/work/W4296838146> ?p ?o ?g. }
Showing items 1 to 73 of
73
with 100 items per page.
- W4296838146 endingPage "1" @default.
- W4296838146 startingPage "1" @default.
- W4296838146 abstract "Background: Anxiety is a widespread disorder that approximately 18% of the population experience at some stage in their lives. Pain is a common stimulus that induces anxiety in both animals and human beings. Combination of drugs with good anti-anxiety and analgesic effect can be used for the treatment of chronic pain induced anxiety, post-operative, and procedure-related pain-induced anxiety. Aims and Objectives: The study was conducted to evaluate the anxiolytic activity of combination of gabapentin with tramadol, pregabalin with tramadol compared to standard fluoxetine, in elevated plus maze (EPM) and light-dark arena (LDA) models of anxiety in Wistar albino rats. Materials and Methods: Twenty-four male or female albino Wistar rats from Central Animal House, MRMC, Kalaburagi, were utilized. Fluoxetine 10 mg/kg, gabapentin 30 mg/kg, tramadol 30 mg/kg, and pregabalin 30 mg/kg were used. Eddy’s hot plate method used for inducing anxiety. EPM and LDA models were used to study the effect of drugs in reducing the pain and anxiety. Results: The present study showed that the exposure to hot plate induces pain, creates anxiety, and reduces locomotor and explorative activity among the rats when exposed to hot plate. There was reduction in anxiety after drug administration, in fluoxetine and gabapentin with tramadol groups with >75% increase in entry into the light chamber or open arm at least once or more during the time period of 5 min when compared to hot plate post-exposure readings. Whereas in pregabalin and tramadol group, it was observed that 25% increase in entry of rats into open arm at least once during the time period of 5 min and 25% decrease in entry of rats into light chamber as compared to those rats after exposure to hot plate. Conclusion: Our study has demonstrated that tramadol, pregabalin, and gabapentin have got analgesic as well as anti-anxiety effects in rats when given in combination. All these experimental data, together with the previous experimental studies and the results reported in this work, suggest that combination of these drugs could be more effective in treating anxiety-related disorders such as chronic pain, pain-induced anxiety, post-operative, and procedure-related pain-induced anxiety with minimal side effects. Further dose ranging studies and models might be necessary to better understand the effects of these drugs in combination." @default.
- W4296838146 created "2022-09-24" @default.
- W4296838146 creator A5001225314 @default.
- W4296838146 creator A5005534088 @default.
- W4296838146 creator A5019163982 @default.
- W4296838146 creator A5029758278 @default.
- W4296838146 creator A5034371725 @default.
- W4296838146 date "2023-01-01" @default.
- W4296838146 modified "2023-09-30" @default.
- W4296838146 title "Evaluation of anxiolytic effect of combination of tramadol with gabapentin and pregabalin in Wistar rats" @default.
- W4296838146 doi "https://doi.org/10.5455/njppp.2023.13.08413202209092022" @default.
- W4296838146 hasPublicationYear "2023" @default.
- W4296838146 type Work @default.
- W4296838146 citedByCount "0" @default.
- W4296838146 crossrefType "journal-article" @default.
- W4296838146 hasAuthorship W4296838146A5001225314 @default.
- W4296838146 hasAuthorship W4296838146A5005534088 @default.
- W4296838146 hasAuthorship W4296838146A5019163982 @default.
- W4296838146 hasAuthorship W4296838146A5029758278 @default.
- W4296838146 hasAuthorship W4296838146A5034371725 @default.
- W4296838146 hasConcept C118552586 @default.
- W4296838146 hasConcept C126322002 @default.
- W4296838146 hasConcept C142724271 @default.
- W4296838146 hasConcept C170493617 @default.
- W4296838146 hasConcept C173586616 @default.
- W4296838146 hasConcept C204787440 @default.
- W4296838146 hasConcept C2775864247 @default.
- W4296838146 hasConcept C2776134451 @default.
- W4296838146 hasConcept C2776468701 @default.
- W4296838146 hasConcept C2776608144 @default.
- W4296838146 hasConcept C2777765862 @default.
- W4296838146 hasConcept C2779777798 @default.
- W4296838146 hasConcept C2780820201 @default.
- W4296838146 hasConcept C42219234 @default.
- W4296838146 hasConcept C558461103 @default.
- W4296838146 hasConcept C71924100 @default.
- W4296838146 hasConcept C98274493 @default.
- W4296838146 hasConceptScore W4296838146C118552586 @default.
- W4296838146 hasConceptScore W4296838146C126322002 @default.
- W4296838146 hasConceptScore W4296838146C142724271 @default.
- W4296838146 hasConceptScore W4296838146C170493617 @default.
- W4296838146 hasConceptScore W4296838146C173586616 @default.
- W4296838146 hasConceptScore W4296838146C204787440 @default.
- W4296838146 hasConceptScore W4296838146C2775864247 @default.
- W4296838146 hasConceptScore W4296838146C2776134451 @default.
- W4296838146 hasConceptScore W4296838146C2776468701 @default.
- W4296838146 hasConceptScore W4296838146C2776608144 @default.
- W4296838146 hasConceptScore W4296838146C2777765862 @default.
- W4296838146 hasConceptScore W4296838146C2779777798 @default.
- W4296838146 hasConceptScore W4296838146C2780820201 @default.
- W4296838146 hasConceptScore W4296838146C42219234 @default.
- W4296838146 hasConceptScore W4296838146C558461103 @default.
- W4296838146 hasConceptScore W4296838146C71924100 @default.
- W4296838146 hasConceptScore W4296838146C98274493 @default.
- W4296838146 hasIssue "0" @default.
- W4296838146 hasLocation W42968381461 @default.
- W4296838146 hasOpenAccess W4296838146 @default.
- W4296838146 hasPrimaryLocation W42968381461 @default.
- W4296838146 hasRelatedWork W1978316762 @default.
- W4296838146 hasRelatedWork W2181486640 @default.
- W4296838146 hasRelatedWork W2522471108 @default.
- W4296838146 hasRelatedWork W2987947316 @default.
- W4296838146 hasRelatedWork W3033124060 @default.
- W4296838146 hasRelatedWork W3166948101 @default.
- W4296838146 hasRelatedWork W3170558001 @default.
- W4296838146 hasRelatedWork W3192394093 @default.
- W4296838146 hasRelatedWork W4296838146 @default.
- W4296838146 hasRelatedWork W2912282424 @default.
- W4296838146 isParatext "false" @default.
- W4296838146 isRetracted "false" @default.
- W4296838146 workType "article" @default.