Matches in SemOpenAlex for { <https://semopenalex.org/work/W4296840985> ?p ?o ?g. }
- W4296840985 abstract "The role of prolactin (PRL) favoring metabolic homeostasis is supported by multiple preclinical and clinical studies. PRL levels are key to explaining the direction of its actions. In contrast with the negative outcomes associated with very high (>100 μg/L) and very low (<7 μg/L) PRL levels, moderately high PRL levels, both within but also above the classically considered physiological range are beneficial for metabolism and have been defined as HomeoFIT-PRL. In animal models, HomeoFIT-PRL levels counteract insulin resistance, glucose intolerance, adipose tissue hypertrophy and fatty liver; and in humans associate with reduced prevalence of insulin resistance, fatty liver, glucose intolerance, metabolic syndrome, reduced adipocyte hypertrophy, and protection from type 2 diabetes development. The beneficial actions of PRL can be explained by its positive effects on main metabolic organs including the pancreas, liver, adipose tissue, and hypothalamus. Here, we briefly review work supporting PRL as a promoter of metabolic homeostasis in rodents and humans, the PRL levels associated with metabolic protection, and the proposed mechanisms involved. Finally, we discuss the possibility of using drugs elevating PRL for the treatment of metabolic diseases." @default.
- W4296840985 created "2022-09-24" @default.
- W4296840985 creator A5001514418 @default.
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- W4296840985 creator A5075962283 @default.
- W4296840985 creator A5082303539 @default.
- W4296840985 date "2022-09-23" @default.
- W4296840985 modified "2023-10-18" @default.
- W4296840985 title "The beneficial metabolic actions of prolactin" @default.
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- W4296840985 doi "https://doi.org/10.3389/fendo.2022.1001703" @default.
- W4296840985 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/36213259" @default.
- W4296840985 hasPublicationYear "2022" @default.