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- W4296844621 abstract "<h3>Abstract</h3> For yet unknown reasons, severely ill COVID-19 patients often become critically ill around the time of activation of adaptive immunity. Here, we show that anti-Spike IgG from serum of severely ill COVID-19 patients induces a hyper-inflammatory response by human macrophages, which subsequently breaks pulmonary endothelial barrier integrity and induces microvascular thrombosis. The excessive inflammatory capacity of this anti-Spike IgG is related to glycosylation changes in the IgG Fc tail. Moreover, the hyper-inflammatory response induced by anti-Spike IgG can be specifically counteracted in vitro by use of the active component of fostamatinib, an FDA- and EMA-approved therapeutic small molecule inhibitor of Syk. <h3>One sentence summary</h3> Anti-Spike IgG promotes hyper-inflammation." @default.
- W4296844621 created "2022-09-24" @default.
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- W4296844621 date "2022-09-23" @default.
- W4296844621 modified "2023-09-27" @default.
- W4296844621 title "Validation of MATCH score: a predictive tool for identification of patients with kelch-like protein-11 autoantibodies" @default.
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- W4296844621 doi "https://doi.org/10.1136/jnnp-2022-329584" @default.
- W4296844621 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/36150843" @default.
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