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- W4296848864 abstract "Medicinal chemists are investigating new methods for the synthesis of alternative scaffolds that can be used as chemotherapeutic agents in the field of medicinal chemistry. Nitrogen-containing heterocycles are well known for their numerous biological activities and play a pivotal role in current drug design and discovery. Among them, pyridine and pyridine-based molecules are privileged pharmacophores that are present in numerous natural products and are tremendously important in biological systems. This electron-deficient heterocycle is present in the important vitamins and in the marketed drugs such as nexium, takepron, actos, etc. Substituted pyridines are reported as anticancer, anti-inflammatory, antifungal, antiproliferative, antitumor, antimicrobial, antitubercular, anti-HIV, and enzyme inhibitors. Inhibition of enzymes is a promising therapeutic strategy to improve a metabolic imbalance or kill a pathogen. Enzyme inhibitors interact with enzymes in a way (temporary or permanent) that prevent the enzymes from functioning normally and decrease the rate of an enzyme-catalyzed reaction. Many of the pyridine drugs are enzyme inhibitors such as indinavir, milrinone, and nevirapine. Promising results with the pyridinyl moiety open up the door for the development of a new generation of inhibitors. This chapter aims to review the progress in enzyme inhibition by pyridine-heterocyclic systems. Due to numerous bioactivities of pyridine-based compounds, they are involved in the drug designing and development process for screening them against diversified therapeutic targets. Among them, several classes of pyridine-based molecules inhibit a variety of clinically important enzymes." @default.
- W4296848864 created "2022-09-24" @default.
- W4296848864 creator A5010594896 @default.
- W4296848864 creator A5025721350 @default.
- W4296848864 creator A5050202051 @default.
- W4296848864 date "2023-01-01" @default.
- W4296848864 modified "2023-09-30" @default.
- W4296848864 title "Role of pyridines as enzyme inhibitors in medicinal chemistry" @default.
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