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- W4296849504 endingPage "101259" @default.
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- W4296849504 abstract "Control of gene expression, including transcription, is central in dictating the outcome of viral infection. One of the profound alterations induced by viruses is modification to the integrity and function of eukaryotic RNA polymerase II (Pol II). Here, we discuss how infection perturbs the Pol II complex by altering subunit phosphorylation and turnover, as well as how cellular genotoxic stress (e.g. DNA damage) elicits similar outcomes. By highlighting emerging parallels and differences in Pol II control during viral infection and abiotic stress, we hope to bolster identification of pathways that target Pol II and regulate the transcriptome." @default.
- W4296849504 created "2022-09-24" @default.
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- W4296849504 date "2022-10-01" @default.
- W4296849504 modified "2023-10-17" @default.
- W4296849504 title "RNA polymerase II subunit modulation during viral infection and cellular stress" @default.
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- W4296849504 doi "https://doi.org/10.1016/j.coviro.2022.101259" @default.
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