Matches in SemOpenAlex for { <https://semopenalex.org/work/W4296879536> ?p ?o ?g. }
- W4296879536 endingPage "16835" @default.
- W4296879536 startingPage "16824" @default.
- W4296879536 abstract "In this work, biologically active α-lipoic acid (ALA) and its isologous 1,2-diselenolane (SeA) and cyclopentyl (CpA) analogues were investigated for their differences in redox potentials, cytotoxicity and ROS production. In addition, the corresponding Pt(IV) complexes comprising ALA (1-4), SeA (5-8) and CpA (9-12) as axial ligands were synthesized. Those Pt(IV) complexes were characterized by NMR spectroscopy, ESI-mass spectrometry and elemental analysis. The cytotoxicity study showed that 1,2-diselenolane containing Pt(IV) (1, 3 and 4) complexes are more cytotoxic than the 1,2-dithiolane analogues (5, 7, and 8) throughout all tested cell lines, intriguingly, cyclopentyl containing species (9, 11 and 12) are the most effective, in some cases even more potent than the parent drug oxaliplatin. Three representative complexes 2, 6 and 10 were further assessed for their redox potentials, reduction with AsA, lipophilicity, cellular accumulation and ROS production. It turned out that the cytotoxicity profile is an overall result of good lipophilicity, high cellular accumulation, and (partially) enhanced ROS generation." @default.
- W4296879536 created "2022-09-24" @default.
- W4296879536 creator A5006380233 @default.
- W4296879536 creator A5038189093 @default.
- W4296879536 creator A5038577505 @default.
- W4296879536 creator A5040979842 @default.
- W4296879536 creator A5043236264 @default.
- W4296879536 creator A5045239850 @default.
- W4296879536 creator A5061166858 @default.
- W4296879536 creator A5061215142 @default.
- W4296879536 creator A5076409244 @default.
- W4296879536 date "2022-01-01" @default.
- W4296879536 modified "2023-10-18" @default.
- W4296879536 title "Novel oxaliplatin(<scp>iv</scp>) complexes conjugated with ligands bearing pendant 1,2-dithiolane/1,2-diselenolane/cyclopentyl motifs" @default.
- W4296879536 cites W1964075368 @default.
- W4296879536 cites W1964940095 @default.
- W4296879536 cites W2002462958 @default.
- W4296879536 cites W2014317382 @default.
- W4296879536 cites W2018639545 @default.
- W4296879536 cites W2026217294 @default.
- W4296879536 cites W2027901828 @default.
- W4296879536 cites W2028871771 @default.
- W4296879536 cites W2034902084 @default.
- W4296879536 cites W2053290880 @default.
- W4296879536 cites W2053544209 @default.
- W4296879536 cites W2054626773 @default.
- W4296879536 cites W2055782963 @default.
- W4296879536 cites W2056832161 @default.
- W4296879536 cites W2059112250 @default.
- W4296879536 cites W2081519457 @default.
- W4296879536 cites W2101539565 @default.
- W4296879536 cites W2140060224 @default.
- W4296879536 cites W2146399575 @default.
- W4296879536 cites W2158626608 @default.
- W4296879536 cites W2202256884 @default.
- W4296879536 cites W2235840692 @default.
- W4296879536 cites W2237427125 @default.
- W4296879536 cites W2282989227 @default.
- W4296879536 cites W2283420536 @default.
- W4296879536 cites W2294386056 @default.
- W4296879536 cites W2401279888 @default.
- W4296879536 cites W2538860994 @default.
- W4296879536 cites W2560175435 @default.
- W4296879536 cites W2561211859 @default.
- W4296879536 cites W2609806320 @default.
- W4296879536 cites W2751456433 @default.
- W4296879536 cites W2783116613 @default.
- W4296879536 cites W2795139701 @default.
- W4296879536 cites W2802809487 @default.
- W4296879536 cites W2884901493 @default.
- W4296879536 cites W2902138215 @default.
- W4296879536 cites W2907813572 @default.
- W4296879536 cites W2913988559 @default.
- W4296879536 cites W2920047505 @default.
- W4296879536 cites W2920392167 @default.
- W4296879536 cites W2931379270 @default.
- W4296879536 cites W2939213051 @default.
- W4296879536 cites W2994686318 @default.
- W4296879536 cites W3007839659 @default.
- W4296879536 cites W3012285865 @default.
- W4296879536 cites W3041426930 @default.
- W4296879536 cites W3094384494 @default.
- W4296879536 cites W3096521890 @default.
- W4296879536 cites W3106856760 @default.
- W4296879536 cites W3108636290 @default.
- W4296879536 cites W3119968354 @default.
- W4296879536 cites W3153831334 @default.
- W4296879536 cites W3156205293 @default.
- W4296879536 cites W3157236378 @default.
- W4296879536 cites W3159871226 @default.
- W4296879536 cites W3163685135 @default.
- W4296879536 cites W3185965919 @default.
- W4296879536 cites W3215620177 @default.
- W4296879536 cites W4200272112 @default.
- W4296879536 cites W4205439099 @default.
- W4296879536 cites W2952197627 @default.
- W4296879536 doi "https://doi.org/10.1039/d2dt02217f" @default.
- W4296879536 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/36189643" @default.
- W4296879536 hasPublicationYear "2022" @default.
- W4296879536 type Work @default.
- W4296879536 citedByCount "1" @default.
- W4296879536 countsByYear W42968795362023 @default.
- W4296879536 crossrefType "journal-article" @default.
- W4296879536 hasAuthorship W4296879536A5006380233 @default.
- W4296879536 hasAuthorship W4296879536A5038189093 @default.
- W4296879536 hasAuthorship W4296879536A5038577505 @default.
- W4296879536 hasAuthorship W4296879536A5040979842 @default.
- W4296879536 hasAuthorship W4296879536A5043236264 @default.
- W4296879536 hasAuthorship W4296879536A5045239850 @default.
- W4296879536 hasAuthorship W4296879536A5061166858 @default.
- W4296879536 hasAuthorship W4296879536A5061215142 @default.
- W4296879536 hasAuthorship W4296879536A5076409244 @default.
- W4296879536 hasConcept C109316439 @default.
- W4296879536 hasConcept C112613896 @default.
- W4296879536 hasConcept C121608353 @default.
- W4296879536 hasConcept C155647269 @default.
- W4296879536 hasConcept C178790620 @default.
- W4296879536 hasConcept C185592680 @default.