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- W4296903160 abstract "Abstract Spinacia oleracea L., Amaranthaceae, leaves cultivated in Egypt demonstrated a potential antileukemic activity against the chronic myeloid leukemia, K562 cell line. Thus, the aim of this study is to carry out a phytochemical investigation of S. oleracea leaves as well as the isolation of its antileukemic phytoconstituents. Phytochemical investigation of S. oleracea leaves resulted in the isolation of seventeen known compounds. The biological study revealed that compounds hexaprenol, phytol, and 18-[(1-oxohexadecyl) oxy]-9-octadecenoic acid exhibited a remarkable antiproliferative activity against K562 cells in vitro . A mechanistic in silico study showed that hexaprenol, phytol, and 18-[(1-oxohexadecyl) oxy]-9-octadecenoic acid exhibited a strong binding affinity towards topoisomerase (docking score −12.50, −9.19, and −13.29 kcal/mol, respectively), and showed as well a strong binding affinity towards Abl kinase (docking score −11.91, −9.35, and −12.59 kcal/mol, respectively). Molecular dynamics study revealed that 18-[(1-oxohexadecyl) oxy]-9-octadecenoic acid produced stable complexes with both topoisomerase and Abl kinase with RMSD values of 1.81 and 1.85 Å, respectively. As a result of our findings, we recommend more in vivo and preclinical studies to confirm the potential benefit of spinach leaves for chronic myeloid leukemia patients. Graphical Abstract" @default.
- W4296903160 created "2022-09-24" @default.
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- W4296903160 date "2022-09-22" @default.
- W4296903160 modified "2023-09-30" @default.
- W4296903160 title "Phytochemical Investigation of Egyptian Spinach Leaves, a Potential Source for Antileukemic Metabolites: In Vitro and In Silico Study" @default.
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- W4296903160 cites W1591627147 @default.
- W4296903160 cites W182770210 @default.
- W4296903160 cites W1929245453 @default.
- W4296903160 cites W1973153679 @default.
- W4296903160 cites W1976280029 @default.
- W4296903160 cites W1979107490 @default.
- W4296903160 cites W1982102245 @default.
- W4296903160 cites W1984555002 @default.
- W4296903160 cites W1991519979 @default.
- W4296903160 cites W1995583190 @default.
- W4296903160 cites W1998891209 @default.
- W4296903160 cites W2003629445 @default.
- W4296903160 cites W2004360022 @default.
- W4296903160 cites W2004647581 @default.
- W4296903160 cites W2013163202 @default.
- W4296903160 cites W2014901423 @default.
- W4296903160 cites W2016656445 @default.
- W4296903160 cites W2019225844 @default.
- W4296903160 cites W2022503973 @default.
- W4296903160 cites W2022583989 @default.
- W4296903160 cites W2033670246 @default.
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- W4296903160 cites W2043122200 @default.
- W4296903160 cites W2047709407 @default.
- W4296903160 cites W2047836537 @default.
- W4296903160 cites W2056982294 @default.
- W4296903160 cites W2062759224 @default.
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- W4296903160 cites W2067949381 @default.
- W4296903160 cites W2067966477 @default.
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- W4296903160 cites W2081693079 @default.
- W4296903160 cites W2084759522 @default.
- W4296903160 cites W2090104667 @default.
- W4296903160 cites W2100906922 @default.
- W4296903160 cites W2108251338 @default.
- W4296903160 cites W2110304037 @default.
- W4296903160 cites W2114199940 @default.
- W4296903160 cites W2114367386 @default.
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- W4296903160 cites W2150994999 @default.
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- W4296903160 cites W2167719636 @default.
- W4296903160 cites W2316243393 @default.
- W4296903160 cites W2328844491 @default.
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- W4296903160 cites W2740297821 @default.
- W4296903160 cites W2791279854 @default.
- W4296903160 cites W2808568435 @default.
- W4296903160 cites W2905630510 @default.
- W4296903160 cites W2927846419 @default.
- W4296903160 cites W2971143276 @default.
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- W4296903160 cites W3095428811 @default.
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- W4296903160 cites W3172336740 @default.
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- W4296903160 doi "https://doi.org/10.1007/s43450-022-00307-0" @default.
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