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- W4296911951 abstract "Abstract The ubiquitously expressed transcription factor TFII-I is a multifunctional protein with pleiotropic roles in gene regulation. TFII-I associated polymorphisms are implicated in Sjögren’s syndrome and Lupus in humans and, germline deletion of the Gtf2i gene in mice leads to embryonic lethality. Here we report a unique role for TFII-I in homeostasis of innate properties of B lymphocytes. Loss of Gtf2i in murine B lineage cells leads to a change in transcriptome and chromatin landscape, which resembles myeloid-like features and coincides with enhanced sensitivity to LPS induced transcription. TFII-I deficient B cells also show increased switching to IgG3, a phenotype associated with inflammation. These results demonstrate a role for TFII-I in maintaining immune homeostasis and provide clues for GTF2I polymorphisms associated with B cell dominated autoimmune diseases in humans." @default.
- W4296911951 created "2022-09-24" @default.
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- W4296911951 date "2022-09-22" @default.
- W4296911951 modified "2023-10-16" @default.
- W4296911951 title "Transcription factor TFII-I fine tunes innate properties of B lymphocytes" @default.
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- W4296911951 doi "https://doi.org/10.1101/2022.09.21.508949" @default.
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