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• W4296922016 abstract "Abstract Background Staphylococcus aureus (S. aureus) is one of the causative agents of bovine mastitis. The treatment using conventional antimicrobial has been hampered due to the development of antimicrobial resistance, the ability of the bacteria to form biofilms and localize inside the host cells. Objectives Here the efficacy of graphene oxide (GO), a carbon-based nanomaterial was tested against the biofilms and intracellular S. aureus in- vitro . Following that, the mechanism for the intracellular antimicrobial activities and GO toxicities were elucidated. Methods GO antibiofilm properties were evaluated based on the disruption of biofilm structure, and the intracellular antimicrobial activities were determined by the survival of S. aureus in infected bovine mammary cells following GO exposure. The mechanism for GO intracellular antimicrobial activities were investigated using endocytosis inhibitors. GO toxicity towards the host cells were assessed using resazurin assay. Results At 100 mg/L GO reduced between 30–70% of S. aureus biofilm mass, suggesting GO’s ability to disrupt the biofilm structure. At 200 mg/L GO killed almost 80% of intracellular S. aureus and the antimicrobial activities were inhibited when cells were pre-treated with cytochalasin D, suggesting GO intracellular antimicrobial activities were dependent on the actin-polymerisation of the cell membrane. At < 250 mg/L, GO enhanced the Mac-T cells viability, and cells were only affected at higher dosages. Conclusion GO efficacy against S. aureus in vitro suggested the compound could be further tested in- vivo to recognise its potential as one of the components of bovine mastitis therapy." @default.
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• W4296922016 date "2022-09-22" @default.
• W4296922016 modified "2023-09-28" @default.
• W4296922016 title "Antimicrobial activities of graphene oxide against biofilm and intracellular Staphylococcus aureus isolated from bovine mastitis" @default.
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• W4296922016 doi "https://doi.org/10.21203/rs.3.rs-2085064/v1" @default.
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