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- W4296954565 abstract "Abstract Aberrant CD19 expression is common in acute myeloid leukemia (AML) with t(8;21)(q22;q22.1). This study aims to investigate the incidence, clinical, immunophenotypic, molecular and cytogenetic associations of CD19 expression, especially in t(8;21) negative AMLs. We evaluated CD19 by flow cytometry (FC) in blasts of 739 consecutive non-promyelocytic AMLs. 52/739 AMLs (7%) expressed CD19 on at least a subset of blasts {range 1–90%, distinct subset (16/52), variable expression (36/52)}. 100/739 CD19 negative (-) cases with available NGS studies were selected as controls. The most common 2016 WHO AML subtypes in the CD19 + group were AML with t(8;21)(q22;q22.1); RUNX1::RUNX1T1 , mutated NPM1 , mutated RUNX1 and biallelic mutation of CEBPA . RUNX1 aberrations including t(8;21) (n = 19), RUNX1 mutations (n = 7), variant RUNX1 translocations (n = 3), RUNX1 deletion (n = 1) and RUNX1 amplification (n = 1), were the most common genetic abnormality in the CD19 + AML (31/52) and were statistically more common than in CD19- AML (11/100) (p = < 0.0001). CD19 was positive in all RUNX1 rearranged cases (n = 22) and 41% (7/17) of the AMLs with RUNX1 mutations. FLT3 mutations were also significantly more common in CD19 + AMLs (20/50, p = 0.001). 42% (14/33) of the CD19 + AMLs showed expression of at least one other B-cell marker by FC (CD22 and/or CD79a). TdT positivity was seen in 25/51 CD19 + AML, including all RUNX1 mutated cases. CD56 was expressed in 14/19 AMLs with t(8;21), but not in any AML with RUNX1 mutations (CD19 + and CD19- groups). 9/9 CD19 + NPM1 mutated AMLs were positive for CD7 compared to only 1/19 AMLs with t(8;21). In conclusion, we found that CD19 is expressed in at least a subset of blasts in ~ 7% of non-promyelocytic AMLs that are enriched in those with RUNX1 aberrations and FLT3 mutations. These cases also highlight that AMLs expressing CD19 can also express other B-cell antigens and must not be misdiagnosed as mixed phenotype acute leukemia." @default.
- W4296954565 created "2022-09-25" @default.
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- W4296954565 date "2022-09-24" @default.
- W4296954565 modified "2023-10-16" @default.
- W4296954565 title "Immunophenotypic and Molecular Cytogenetic Associations of CD19 Expression in Acute Myeloid Leukemias, including in the t(8;21) negative setting" @default.
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- W4296954565 doi "https://doi.org/10.21203/rs.3.rs-2023169/v1" @default.
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