FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4296959205> ?p ?o ?g. }

• W4296959205 endingPage "85" @default.
• W4296959205 startingPage "72" @default.
• W4296959205 abstract "Abstract Background Allodynia and hyperalgesia are common signs in individuals with complex regional pain syndrome (CRPS), mainly attributed to sensitization of the nociceptive system. Appropriate diagnostic tools for the objective assessment of such hypersensitivities are still lacking, which are essential for the development of mechanism‐based treatment strategies. Objectives This study investigated the use of pain‐autonomic readouts to objectively detect sensitization processes in CRPS. Methods Twenty individuals with chronic CRPS were recruited for the study alongside 16 age‐ and sex‐matched healthy controls (HC). All individuals underwent quantitative sensory testing and neurophysiological assessments. Sympathetic skin responses (SSRs) were recorded in response to 15 pinprick and 15 noxious heat stimuli of the affected (CRPS hand/foot) and a control area (contralateral shoulder/hand). Results Individuals with CRPS showed increased mechanical pain sensitivity and increased SSR amplitudes compared with HC in response to pinprick and heat stimulation of the affected ( p < 0.001), but not in the control area ( p > 0.05). Habituation of pinprick‐induced SSRs was reduced in CRPS compared to HC in both the affected ( p = 0.018) and slightly in the control area ( p = 0.048). Habituation of heat‐induced SSR was reduced in CRPS in the affected ( p = 0.008), but not the control area ( p = 0.053). Conclusions This is the first study demonstrating clinical evidence that pain‐related autonomic responses may represent objective tools to quantify sensitization processes along the nociceptive neuraxis in CRPS (e.g. widespread hyperexcitability). Pain‐autonomic readouts could help scrutinize mechanisms underlying the development and maintenance of chronic pain in CRPS and provide valuable metrics to detect mechanism‐based treatment responses in clinical trials. Significance This study provides clinical evidence that autonomic measures to noxious stimuli can objectively detect sensitization processes along the nociceptive neuraxis in complex regional pain syndrome (CRPS) (e.g. widespread hyperexcitability). Pain‐autonomic readouts may represent valuable tools to explore pathophysiological mechanisms in a variety of pain patients and offer novel avenues to help guide mechanism‐based therapeutic strategies." @default.
• W4296959205 created "2022-09-25" @default.
• W4296959205 creator A5012717312 @default.
• W4296959205 creator A5020251712 @default.
• W4296959205 creator A5032775119 @default.
• W4296959205 creator A5069598374 @default.
• W4296959205 creator A5076930866 @default.
• W4296959205 creator A5080401469 @default.
• W4296959205 date "2022-10-10" @default.
• W4296959205 modified "2023-10-17" @default.
• W4296959205 title "Pain‐autonomic measures reveal nociceptive sensitization in complex regional pain syndrome" @default.
• W4296959205 cites W1896668466 @default.
• W4296959205 cites W1999610083 @default.
• W4296959205 cites W2022433082 @default.
• W4296959205 cites W2025580202 @default.
• W4296959205 cites W2033603665 @default.
• W4296959205 cites W2035537141 @default.
• W4296959205 cites W2037698913 @default.
• W4296959205 cites W2047247840 @default.
• W4296959205 cites W2055349649 @default.
• W4296959205 cites W2061222262 @default.
• W4296959205 cites W2063303321 @default.
• W4296959205 cites W2075263835 @default.
• W4296959205 cites W2075606393 @default.
• W4296959205 cites W2092937683 @default.
• W4296959205 cites W2101331471 @default.
• W4296959205 cites W2108197576 @default.
• W4296959205 cites W2108978334 @default.
• W4296959205 cites W2111631879 @default.
• W4296959205 cites W2113045093 @default.
• W4296959205 cites W2122097870 @default.
• W4296959205 cites W2129164963 @default.
• W4296959205 cites W2137232129 @default.
• W4296959205 cites W2143077460 @default.
• W4296959205 cites W2149913327 @default.
• W4296959205 cites W2155524482 @default.
• W4296959205 cites W2160662805 @default.
• W4296959205 cites W2162096619 @default.
• W4296959205 cites W2162816987 @default.
• W4296959205 cites W2224771370 @default.
• W4296959205 cites W2346855238 @default.
• W4296959205 cites W2552402939 @default.
• W4296959205 cites W2735416859 @default.
• W4296959205 cites W2757237148 @default.
• W4296959205 cites W2766251233 @default.
• W4296959205 cites W2777433509 @default.
• W4296959205 cites W2793008665 @default.
• W4296959205 cites W2793093126 @default.
• W4296959205 cites W2800119642 @default.
• W4296959205 cites W2804472076 @default.
• W4296959205 cites W2898610572 @default.
• W4296959205 cites W2906596360 @default.
• W4296959205 cites W2945721825 @default.
• W4296959205 cites W2953117785 @default.
• W4296959205 cites W3049429275 @default.
• W4296959205 cites W3135846415 @default.
• W4296959205 cites W4281630239 @default.
• W4296959205 cites W4296959205 @default.
• W4296959205 doi "https://doi.org/10.1002/ejp.2040" @default.
• W4296959205 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/36130736" @default.
• W4296959205 hasPublicationYear "2022" @default.
• W4296959205 type Work @default.
• W4296959205 citedByCount "4" @default.
• W4296959205 countsByYear W42969592052022 @default.
• W4296959205 countsByYear W42969592052023 @default.
• W4296959205 crossrefType "journal-article" @default.
• W4296959205 hasAuthorship W4296959205A5012717312 @default.
• W4296959205 hasAuthorship W4296959205A5020251712 @default.
• W4296959205 hasAuthorship W4296959205A5032775119 @default.
• W4296959205 hasAuthorship W4296959205A5069598374 @default.
• W4296959205 hasAuthorship W4296959205A5076930866 @default.
• W4296959205 hasAuthorship W4296959205A5080401469 @default.
• W4296959205 hasBestOaLocation W42969592051 @default.
• W4296959205 hasConcept C126322002 @default.
• W4296959205 hasConcept C15490471 @default.
• W4296959205 hasConcept C15744967 @default.
• W4296959205 hasConcept C169760540 @default.
• W4296959205 hasConcept C170493617 @default.
• W4296959205 hasConcept C172659308 @default.
• W4296959205 hasConcept C1862650 @default.
• W4296959205 hasConcept C203014093 @default.
• W4296959205 hasConcept C2776217527 @default.
• W4296959205 hasConcept C2777883359 @default.
• W4296959205 hasConcept C2779245659 @default.
• W4296959205 hasConcept C2780226346 @default.
• W4296959205 hasConcept C2781118164 @default.
• W4296959205 hasConcept C2909026353 @default.
• W4296959205 hasConcept C3019020247 @default.
• W4296959205 hasConcept C3673659 @default.
• W4296959205 hasConcept C42219234 @default.
• W4296959205 hasConcept C50610925 @default.
• W4296959205 hasConcept C548259974 @default.
• W4296959205 hasConcept C71924100 @default.
• W4296959205 hasConcept C94487597 @default.
• W4296959205 hasConceptScore W4296959205C126322002 @default.
• W4296959205 hasConceptScore W4296959205C15490471 @default.
• W4296959205 hasConceptScore W4296959205C15744967 @default.
• W4296959205 hasConceptScore W4296959205C169760540 @default.

• next