Matches in SemOpenAlex for { <https://semopenalex.org/work/W4296986543> ?p ?o ?g. }
Showing items 1 to 100 of
100
with 100 items per page.
- W4296986543 endingPage "785" @default.
- W4296986543 startingPage "779" @default.
- W4296986543 abstract "Abnormal expression of miR-199 is related to proliferation of Parkinson’s cells. Lipid nano emulsions can effectively inhibit cell growth. This study mainly explored whether lipid nano emulsions may regulate the expression of miR-199, thereby affecting Parkinson’s cells. SH-SY5Y Parkinson’s cells treated with 20 μ mol/L miR-199 in SH-SY5Y cells, or both 20 μ mol/L lipid nanoemulsion were used to intervene SH-SY5Y cells. Intervention time was set at 0, 6, 12, and 24 h, respectively. We used 20 μ mol/L lipid nano emulsion to interfere with SH-SY5Y cells that were transfected with miR-199. We observed proliferation number and cell cycle changes after lipid nanoemulsion intervention in the SH-SY5Y cells. We also observed the expression of NF- κ B pathway factor protein and verified that P65 is the direct downstream of miR-199. The higher the concentration of lipid nanoemulsion was, the more significant the decreased cell proliferation. The concentration of lipid nanoemulsion was 20 μ mol/L, which decreased obviously ( P < 0.01). Cell numbers in 20 μ mol/L curcumin lipid nanoemulsion began to show an evident downward trend from 24 h, where cells from the G0/G1 phase increased and those in G2/M phase decreased significantly ( P < 0.05). The higher the dose of lipid nanoemulsion, the higher the miR-199 expression, which showed a concentration and dose-dependence. The number of cells in the lipid nanoemulsion+miR-NC group was lowest. NF- κ B is the direct target gene of miR-199. When the lipid nanoemulsion concentration was 20 μ mol/L, the expression of P65 protein decreased. Lipid nano emulsion can therefore inhibit proliferation of Parkinson’s cells, and cell number in the S phase and G2/M phase, so that many cells are blocked in the G0/G1 phase, which then control cell growth. Lipid nano emulsion works mainly through miR-199/NF- κ B axis, where miR-199 negatively regulates the NF- κ B pathway, and ultimately controls abnormal cell proliferation." @default.
- W4296986543 created "2022-09-25" @default.
- W4296986543 creator A5002472609 @default.
- W4296986543 creator A5005247857 @default.
- W4296986543 creator A5039931061 @default.
- W4296986543 creator A5042312596 @default.
- W4296986543 creator A5062755510 @default.
- W4296986543 creator A5063564807 @default.
- W4296986543 creator A5090281350 @default.
- W4296986543 date "2022-04-01" @default.
- W4296986543 modified "2023-09-27" @default.
- W4296986543 title "Lipid Nanoemulsion Regulates Parkinson’s Cell Cycle and Proliferation Through miR-199/NF-<i>κ</i>B Pathway" @default.
- W4296986543 cites W1994430972 @default.
- W4296986543 cites W2012899584 @default.
- W4296986543 cites W2014958223 @default.
- W4296986543 cites W2026763513 @default.
- W4296986543 cites W2092638080 @default.
- W4296986543 cites W2096514882 @default.
- W4296986543 cites W2116867077 @default.
- W4296986543 cites W2269446361 @default.
- W4296986543 cites W2504570392 @default.
- W4296986543 cites W2625989536 @default.
- W4296986543 cites W2792640679 @default.
- W4296986543 cites W2899135644 @default.
- W4296986543 cites W3019035977 @default.
- W4296986543 cites W3021874712 @default.
- W4296986543 cites W3042728135 @default.
- W4296986543 cites W3088986733 @default.
- W4296986543 cites W3091271587 @default.
- W4296986543 cites W3091437802 @default.
- W4296986543 cites W3101888604 @default.
- W4296986543 cites W3112834410 @default.
- W4296986543 cites W3154376301 @default.
- W4296986543 cites W3206495843 @default.
- W4296986543 cites W3210825843 @default.
- W4296986543 cites W3214427600 @default.
- W4296986543 doi "https://doi.org/10.1166/sam.2022.4253" @default.
- W4296986543 hasPublicationYear "2022" @default.
- W4296986543 type Work @default.
- W4296986543 citedByCount "0" @default.
- W4296986543 crossrefType "journal-article" @default.
- W4296986543 hasAuthorship W4296986543A5002472609 @default.
- W4296986543 hasAuthorship W4296986543A5005247857 @default.
- W4296986543 hasAuthorship W4296986543A5039931061 @default.
- W4296986543 hasAuthorship W4296986543A5042312596 @default.
- W4296986543 hasAuthorship W4296986543A5062755510 @default.
- W4296986543 hasAuthorship W4296986543A5063564807 @default.
- W4296986543 hasAuthorship W4296986543A5090281350 @default.
- W4296986543 hasConcept C104317684 @default.
- W4296986543 hasConcept C1491633281 @default.
- W4296986543 hasConcept C185592680 @default.
- W4296986543 hasConcept C192562407 @default.
- W4296986543 hasConcept C25095133 @default.
- W4296986543 hasConcept C2776715637 @default.
- W4296986543 hasConcept C2779083432 @default.
- W4296986543 hasConcept C29537977 @default.
- W4296986543 hasConcept C4733338 @default.
- W4296986543 hasConcept C54009773 @default.
- W4296986543 hasConcept C54355233 @default.
- W4296986543 hasConcept C55493867 @default.
- W4296986543 hasConcept C62112901 @default.
- W4296986543 hasConcept C81885089 @default.
- W4296986543 hasConcept C86803240 @default.
- W4296986543 hasConcept C95444343 @default.
- W4296986543 hasConceptScore W4296986543C104317684 @default.
- W4296986543 hasConceptScore W4296986543C1491633281 @default.
- W4296986543 hasConceptScore W4296986543C185592680 @default.
- W4296986543 hasConceptScore W4296986543C192562407 @default.
- W4296986543 hasConceptScore W4296986543C25095133 @default.
- W4296986543 hasConceptScore W4296986543C2776715637 @default.
- W4296986543 hasConceptScore W4296986543C2779083432 @default.
- W4296986543 hasConceptScore W4296986543C29537977 @default.
- W4296986543 hasConceptScore W4296986543C4733338 @default.
- W4296986543 hasConceptScore W4296986543C54009773 @default.
- W4296986543 hasConceptScore W4296986543C54355233 @default.
- W4296986543 hasConceptScore W4296986543C55493867 @default.
- W4296986543 hasConceptScore W4296986543C62112901 @default.
- W4296986543 hasConceptScore W4296986543C81885089 @default.
- W4296986543 hasConceptScore W4296986543C86803240 @default.
- W4296986543 hasConceptScore W4296986543C95444343 @default.
- W4296986543 hasIssue "4" @default.
- W4296986543 hasLocation W42969865431 @default.
- W4296986543 hasOpenAccess W4296986543 @default.
- W4296986543 hasPrimaryLocation W42969865431 @default.
- W4296986543 hasRelatedWork W2066519212 @default.
- W4296986543 hasRelatedWork W2072481810 @default.
- W4296986543 hasRelatedWork W2351812146 @default.
- W4296986543 hasRelatedWork W2356588131 @default.
- W4296986543 hasRelatedWork W2357914589 @default.
- W4296986543 hasRelatedWork W2362650308 @default.
- W4296986543 hasRelatedWork W2363981381 @default.
- W4296986543 hasRelatedWork W2374592133 @default.
- W4296986543 hasRelatedWork W2387175565 @default.
- W4296986543 hasRelatedWork W2390355553 @default.
- W4296986543 hasVolume "14" @default.
- W4296986543 isParatext "false" @default.
- W4296986543 isRetracted "false" @default.
- W4296986543 workType "article" @default.