Matches in SemOpenAlex for { <https://semopenalex.org/work/W4296988911> ?p ?o ?g. }
Showing items 1 to 88 of
88
with 100 items per page.
- W4296988911 endingPage "1567" @default.
- W4296988911 startingPage "1562" @default.
- W4296988911 abstract "Ovarian clear cell carcinoma (OCCC) is a subtype of ovarian cancer with unique features at histological and molecular levels. The prevalence of OCCC is higher in east Asia than in Western countries. As cases are usually chemo-resistant, treatment effects of platinum-based chemotherapy are not satisfactory, especially for patients with stage III or IV disease. Immune checkpoint inhibitors (ICIs) have revolutionized the treatment of patients with advanced-stage cancers. However, whether advanced OCCC patients benefit from ICIs remains elusive.Herein, we report a Chinese patient with stage IIIB inoperable OCCC who was resistant to platinum-based chemotherapy and anlotinib. Next-generation sequencing (NGS) revealed a pathogenic polymerase epsilon (POLE) P286R mutation and a high level of tumor mutation burden (TMB) in tissue and plasma samples. The ICI sintilimab was then used with bevacizumab as third-line treatment. Tumor reduction was observed, and the patient underwent surgical resection which indicated a pathologic complete response (pCR). Maintenance therapy with sintilimab and bevacizumab was applied, and the patient has achieved overall survival (OS) of 35 months since the diagnosis. They have also achieved a progression-free survival (PFS) of 29 months since commencing ICI treatment and have been disease-free for 24 months after surgical resection.The treatment effect of ICI in POLE-mutant OCCC patients has been rarely reported. The treatment benefits observed in the stage IIIB OCCC patient who was resistant to platinum-based chemotherapy may be associated with the presence of POLE mutation and a high level of TMB. Comprehensive genomic profiling could contribute to appropriate treatment decisions for OCCC." @default.
- W4296988911 created "2022-09-25" @default.
- W4296988911 creator A5003226007 @default.
- W4296988911 creator A5019708695 @default.
- W4296988911 creator A5032240099 @default.
- W4296988911 creator A5060844380 @default.
- W4296988911 creator A5077863311 @default.
- W4296988911 date "2022-09-01" @default.
- W4296988911 modified "2023-09-22" @default.
- W4296988911 title "Pathologic complete response to immune checkpoint inhibitor in a stage IIIB ovarian clear cell carcinoma patient with POLE mutation resistant to platinum-based chemotherapy: a case report" @default.
- W4296988911 cites W2469265662 @default.
- W4296988911 cites W2594054039 @default.
- W4296988911 cites W2772038399 @default.
- W4296988911 cites W2918948206 @default.
- W4296988911 cites W2986623051 @default.
- W4296988911 cites W2995204555 @default.
- W4296988911 cites W3087700560 @default.
- W4296988911 cites W3121717072 @default.
- W4296988911 cites W3136330220 @default.
- W4296988911 cites W3138401050 @default.
- W4296988911 cites W3207545552 @default.
- W4296988911 cites W4212850558 @default.
- W4296988911 cites W4214873887 @default.
- W4296988911 cites W4224308586 @default.
- W4296988911 doi "https://doi.org/10.21037/gs-22-420" @default.
- W4296988911 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/36221285" @default.
- W4296988911 hasPublicationYear "2022" @default.
- W4296988911 type Work @default.
- W4296988911 citedByCount "0" @default.
- W4296988911 crossrefType "journal-article" @default.
- W4296988911 hasAuthorship W4296988911A5003226007 @default.
- W4296988911 hasAuthorship W4296988911A5019708695 @default.
- W4296988911 hasAuthorship W4296988911A5032240099 @default.
- W4296988911 hasAuthorship W4296988911A5060844380 @default.
- W4296988911 hasAuthorship W4296988911A5077863311 @default.
- W4296988911 hasBestOaLocation W42969889111 @default.
- W4296988911 hasConcept C121608353 @default.
- W4296988911 hasConcept C126322002 @default.
- W4296988911 hasConcept C143998085 @default.
- W4296988911 hasConcept C146357865 @default.
- W4296988911 hasConcept C151730666 @default.
- W4296988911 hasConcept C2776694085 @default.
- W4296988911 hasConcept C2777546739 @default.
- W4296988911 hasConcept C2777802072 @default.
- W4296988911 hasConcept C2778822529 @default.
- W4296988911 hasConcept C2780427987 @default.
- W4296988911 hasConcept C2781199814 @default.
- W4296988911 hasConcept C2781230642 @default.
- W4296988911 hasConcept C3019054536 @default.
- W4296988911 hasConcept C71924100 @default.
- W4296988911 hasConcept C86803240 @default.
- W4296988911 hasConceptScore W4296988911C121608353 @default.
- W4296988911 hasConceptScore W4296988911C126322002 @default.
- W4296988911 hasConceptScore W4296988911C143998085 @default.
- W4296988911 hasConceptScore W4296988911C146357865 @default.
- W4296988911 hasConceptScore W4296988911C151730666 @default.
- W4296988911 hasConceptScore W4296988911C2776694085 @default.
- W4296988911 hasConceptScore W4296988911C2777546739 @default.
- W4296988911 hasConceptScore W4296988911C2777802072 @default.
- W4296988911 hasConceptScore W4296988911C2778822529 @default.
- W4296988911 hasConceptScore W4296988911C2780427987 @default.
- W4296988911 hasConceptScore W4296988911C2781199814 @default.
- W4296988911 hasConceptScore W4296988911C2781230642 @default.
- W4296988911 hasConceptScore W4296988911C3019054536 @default.
- W4296988911 hasConceptScore W4296988911C71924100 @default.
- W4296988911 hasConceptScore W4296988911C86803240 @default.
- W4296988911 hasIssue "9" @default.
- W4296988911 hasLocation W42969889111 @default.
- W4296988911 hasLocation W42969889112 @default.
- W4296988911 hasLocation W42969889113 @default.
- W4296988911 hasOpenAccess W4296988911 @default.
- W4296988911 hasPrimaryLocation W42969889111 @default.
- W4296988911 hasRelatedWork W2037617518 @default.
- W4296988911 hasRelatedWork W2042861937 @default.
- W4296988911 hasRelatedWork W2072213084 @default.
- W4296988911 hasRelatedWork W2084373588 @default.
- W4296988911 hasRelatedWork W2148187838 @default.
- W4296988911 hasRelatedWork W2418204902 @default.
- W4296988911 hasRelatedWork W2805900528 @default.
- W4296988911 hasRelatedWork W3016694168 @default.
- W4296988911 hasRelatedWork W4376644351 @default.
- W4296988911 hasRelatedWork W99287364 @default.
- W4296988911 hasVolume "11" @default.
- W4296988911 isParatext "false" @default.
- W4296988911 isRetracted "false" @default.
- W4296988911 workType "article" @default.