Matches in SemOpenAlex for { <https://semopenalex.org/work/W4296992743> ?p ?o ?g. }
- W4296992743 endingPage "1295" @default.
- W4296992743 startingPage "1295" @default.
- W4296992743 abstract "Carbapenem resistance (CR) is an emerging health issue. Epidemiological surveys on carbapenem-resistant Gram-negative bacilli (CR-GNB) in Lebanon remain scarce. In this study, we determined the prevalence of CR-GNB isolated between 2015 to 2019 in three hospitals in northern Lebanon: 311 CR-Enterobacterales (out of 11210; 2.8%), 155 CR-Pseudomonas (out of 1034; 15%) and 106 CR- Acinetobacter (out of 184; 57.6%) were identified. CR mechanisms were determined for 146 randomly chosen isolates: the Carba NP test revealed an enzymatic resistance to carbapenems in 109 isolates (out of 146, 74.7%). Produced carbapenemases were evaluated by the NG-Test Carba5, NG-Test OXA-23 immunochromatographic assays and PCR. Carbapenemase-producing (CP) Enterobacterales expressed blaOXA-48-like, blaNDM-like and blaVIM-like genes and CP-Pseudomonas expressed blaIMP-like and blaVIM-like genes, whereas CP-Acinetobacter expressed blaOXA-23-like genes. The NG-Test Carba5 results were confirmed by PCR sequencing and revealed several variants, such as NDM-19, VIM-62 and OXA-162, never described so far in Lebanon. Isolates with discordant results were sequenced by WGS and highlighted novel variants of the natural oxacillinases of Pseudomonas aeruginosa: blaOXA-50-like genes. Their role in carbapenem resistance should be further studied. Overall, our findings highlight an alarming situation and encourage health care centers to establish performant registration systems that could help in limiting resistance spread." @default.
- W4296992743 created "2022-09-25" @default.
- W4296992743 creator A5005584893 @default.
- W4296992743 creator A5008710955 @default.
- W4296992743 creator A5025852307 @default.
- W4296992743 creator A5027551310 @default.
- W4296992743 creator A5029034527 @default.
- W4296992743 creator A5034763831 @default.
- W4296992743 creator A5037361850 @default.
- W4296992743 creator A5045995347 @default.
- W4296992743 creator A5045995622 @default.
- W4296992743 creator A5046300802 @default.
- W4296992743 creator A5049589918 @default.
- W4296992743 creator A5063063917 @default.
- W4296992743 creator A5082031626 @default.
- W4296992743 creator A5089802438 @default.
- W4296992743 date "2022-09-22" @default.
- W4296992743 modified "2023-10-14" @default.
- W4296992743 title "Prevalence and Molecular Mechanisms of Carbapenem Resistance among Gram-Negative Bacilli in Three Hospitals of Northern Lebanon" @default.
- W4296992743 cites W1845997799 @default.
- W4296992743 cites W2068362753 @default.
- W4296992743 cites W2074958615 @default.
- W4296992743 cites W2112203749 @default.
- W4296992743 cites W2117043113 @default.
- W4296992743 cites W2129616454 @default.
- W4296992743 cites W2143874510 @default.
- W4296992743 cites W2145041871 @default.
- W4296992743 cites W2149364343 @default.
- W4296992743 cites W2158518385 @default.
- W4296992743 cites W2162176562 @default.
- W4296992743 cites W2162199214 @default.
- W4296992743 cites W2254805360 @default.
- W4296992743 cites W2297856069 @default.
- W4296992743 cites W2414826562 @default.
- W4296992743 cites W2556413004 @default.
- W4296992743 cites W2763708963 @default.
- W4296992743 cites W2765458899 @default.
- W4296992743 cites W2792688487 @default.
- W4296992743 cites W2896645548 @default.
- W4296992743 cites W2903860867 @default.
- W4296992743 cites W2911545797 @default.
- W4296992743 cites W2917884495 @default.
- W4296992743 cites W2922409533 @default.
- W4296992743 cites W2938723873 @default.
- W4296992743 cites W2944190894 @default.
- W4296992743 cites W2969690451 @default.
- W4296992743 cites W2971576723 @default.
- W4296992743 cites W2972457872 @default.
- W4296992743 cites W3034028803 @default.
- W4296992743 cites W3048398081 @default.
- W4296992743 cites W3048424594 @default.
- W4296992743 cites W3098390524 @default.
- W4296992743 cites W3133153802 @default.
- W4296992743 cites W3133940382 @default.
- W4296992743 cites W3180560500 @default.
- W4296992743 cites W3185164351 @default.
- W4296992743 cites W3196892672 @default.
- W4296992743 cites W3200878990 @default.
- W4296992743 cites W4225273863 @default.
- W4296992743 cites W4280583609 @default.
- W4296992743 cites W4283378514 @default.
- W4296992743 doi "https://doi.org/10.3390/antibiotics11101295" @default.
- W4296992743 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/36289953" @default.
- W4296992743 hasPublicationYear "2022" @default.
- W4296992743 type Work @default.
- W4296992743 citedByCount "2" @default.
- W4296992743 countsByYear W42969927432022 @default.
- W4296992743 countsByYear W42969927432023 @default.
- W4296992743 crossrefType "journal-article" @default.
- W4296992743 hasAuthorship W4296992743A5005584893 @default.
- W4296992743 hasAuthorship W4296992743A5008710955 @default.
- W4296992743 hasAuthorship W4296992743A5025852307 @default.
- W4296992743 hasAuthorship W4296992743A5027551310 @default.
- W4296992743 hasAuthorship W4296992743A5029034527 @default.
- W4296992743 hasAuthorship W4296992743A5034763831 @default.
- W4296992743 hasAuthorship W4296992743A5037361850 @default.
- W4296992743 hasAuthorship W4296992743A5045995347 @default.
- W4296992743 hasAuthorship W4296992743A5045995622 @default.
- W4296992743 hasAuthorship W4296992743A5046300802 @default.
- W4296992743 hasAuthorship W4296992743A5049589918 @default.
- W4296992743 hasAuthorship W4296992743A5063063917 @default.
- W4296992743 hasAuthorship W4296992743A5082031626 @default.
- W4296992743 hasAuthorship W4296992743A5089802438 @default.
- W4296992743 hasBestOaLocation W42969927431 @default.
- W4296992743 hasConcept C104317684 @default.
- W4296992743 hasConcept C2776315533 @default.
- W4296992743 hasConcept C2776685102 @default.
- W4296992743 hasConcept C2776870249 @default.
- W4296992743 hasConcept C2777637488 @default.
- W4296992743 hasConcept C2778523567 @default.
- W4296992743 hasConcept C2781463711 @default.
- W4296992743 hasConcept C501593827 @default.
- W4296992743 hasConcept C523546767 @default.
- W4296992743 hasConcept C54355233 @default.
- W4296992743 hasConcept C86803240 @default.
- W4296992743 hasConcept C89423630 @default.
- W4296992743 hasConceptScore W4296992743C104317684 @default.
- W4296992743 hasConceptScore W4296992743C2776315533 @default.