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- W4296993556 abstract "The disturbance in gut microbiota composition and metabolism has been implicated in the process of pathogenic bacteria infection. However, the characteristics of the microbiota and the metabolic interaction of commensals−host during pathogen invasion remain more than vague. In this study, the potential associations of gut microbes with disturbed lipid metabolism in mice upon carbapenem-resistant Escherichia coli (CRE) infection were explored by the biochemical and multi-omics approaches including metagenomics, metabolomics and lipidomics, and then the key metabolites−reaction−enzyme−gene interaction network was constructed. Results showed that intestinal Erysipelotrichaceae family was strongly associated with the hepatic total cholesterol and HDL-cholesterol, as well as a few sera and fecal metabolites involved in lipid metabolism such as 24, 25-dihydrolanosterol. A high-coverage lipidomic analysis further demonstrated that a total of 529 lipid molecules was significantly enriched and 520 were depleted in the liver of mice infected with CRE. Among them, 35 lipid species showed high correlations (|r| > 0.8 and p < 0.05) with the Erysipelotrichaceae family, including phosphatidylglycerol (42:2), phosphatidylglycerol (42:3), phosphatidylglycerol (38:5), phosphatidylcholine (42:4), ceramide (d17:1/16:0), ceramide (d18:1/16:0) and diacylglycerol (20:2), with correlation coefficients higher than 0.9. In conclusion, the systematic multi-omics study improved the understanding of the complicated connection between the microbiota and the host during pathogen invasion, which thereby is expected to lead to the future discovery and establishment of novel control strategies for CRE infection." @default.
- W4296993556 created "2022-09-25" @default.
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- W4296993556 date "2022-09-22" @default.
- W4296993556 modified "2023-10-06" @default.
- W4296993556 title "Integrated Analysis of Gut Microbiome and Lipid Metabolism in Mice Infected with Carbapenem-Resistant Enterobacteriaceae" @default.
- W4296993556 cites W1898460539 @default.
- W4296993556 cites W1928006796 @default.
- W4296993556 cites W1974770909 @default.
- W4296993556 cites W1989200494 @default.
- W4296993556 cites W2001561488 @default.
- W4296993556 cites W2010987861 @default.
- W4296993556 cites W2017352107 @default.
- W4296993556 cites W2018175015 @default.
- W4296993556 cites W2022497999 @default.
- W4296993556 cites W2033541022 @default.
- W4296993556 cites W2034598141 @default.
- W4296993556 cites W2037881903 @default.
- W4296993556 cites W2042755777 @default.
- W4296993556 cites W2043331317 @default.
- W4296993556 cites W2049914201 @default.
- W4296993556 cites W2068687524 @default.
- W4296993556 cites W2070126347 @default.
- W4296993556 cites W2081653606 @default.
- W4296993556 cites W2082220008 @default.
- W4296993556 cites W2087544355 @default.
- W4296993556 cites W2100096695 @default.
- W4296993556 cites W2110065044 @default.
- W4296993556 cites W2112961075 @default.
- W4296993556 cites W2119623639 @default.
- W4296993556 cites W2134469465 @default.
- W4296993556 cites W2136778785 @default.
- W4296993556 cites W2140918313 @default.
- W4296993556 cites W2146651969 @default.
- W4296993556 cites W2152311269 @default.
- W4296993556 cites W2158353135 @default.
- W4296993556 cites W2161241326 @default.
- W4296993556 cites W2171815113 @default.
- W4296993556 cites W2179544415 @default.
- W4296993556 cites W2212012622 @default.
- W4296993556 cites W2260606606 @default.
- W4296993556 cites W2265226248 @default.
- W4296993556 cites W2266829376 @default.
- W4296993556 cites W2300552860 @default.
- W4296993556 cites W2320251182 @default.
- W4296993556 cites W2463312000 @default.
- W4296993556 cites W2486975460 @default.
- W4296993556 cites W2490472137 @default.
- W4296993556 cites W2522015218 @default.
- W4296993556 cites W2559621415 @default.
- W4296993556 cites W2560002818 @default.
- W4296993556 cites W2563720483 @default.
- W4296993556 cites W2587514660 @default.
- W4296993556 cites W2608598271 @default.
- W4296993556 cites W2620068414 @default.
- W4296993556 cites W2743073899 @default.
- W4296993556 cites W2757303946 @default.
- W4296993556 cites W2766612189 @default.
- W4296993556 cites W2768617092 @default.
- W4296993556 cites W2768748254 @default.
- W4296993556 cites W2772917808 @default.
- W4296993556 cites W2776579174 @default.
- W4296993556 cites W2888718738 @default.
- W4296993556 cites W2890403222 @default.
- W4296993556 cites W2894873183 @default.
- W4296993556 cites W2912906332 @default.
- W4296993556 cites W2913156301 @default.
- W4296993556 cites W2958074659 @default.
- W4296993556 cites W2969382641 @default.
- W4296993556 cites W2975601106 @default.
- W4296993556 cites W2982531730 @default.
- W4296993556 cites W2997389909 @default.
- W4296993556 cites W3007020664 @default.
- W4296993556 cites W3016758705 @default.
- W4296993556 cites W3023000873 @default.
- W4296993556 cites W3027589927 @default.
- W4296993556 cites W3040176075 @default.
- W4296993556 cites W3119285590 @default.
- W4296993556 cites W3120962607 @default.
- W4296993556 cites W3135589584 @default.
- W4296993556 cites W3167457904 @default.
- W4296993556 cites W3195627102 @default.
- W4296993556 cites W4206237086 @default.
- W4296993556 cites W4225263240 @default.
- W4296993556 cites W4225330696 @default.
- W4296993556 cites W4247331516 @default.
- W4296993556 doi "https://doi.org/10.3390/metabo12100892" @default.
- W4296993556 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/36295794" @default.