FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4297000623> ?p ?o ?g. }

• W4297000623 abstract "Erythrocyte invasion by P. falciparum involves functionally overlapping interactions between the parasite's ligands and the erythrocyte surface receptors. While some P. falciparum isolates necessarily engage the sialic acid (SA) moieties of the erythrocytes during the invasion, others use ligands whose binding is independent of SA for successful invasion. Deciphering the major pathway used by P. falciparum clinical isolates represent a key step toward developing an efficient blood stage malaria vaccine.We collected a total of 156 malaria-infected samples from Ghanaian children aged 2 to 14 years and used a two-color flow cytometry-based invasion assay to assess the invasion phenotype diversity of Ghanaian P. falciparum clinical isolates. Anti-human CR1 antibodies were used to determine the relative contribution of the PfRh4-CR1 interaction in the parasites invasion phenotype and RT-qPCR was used to assess the expression levels of key invasion-related ligands.Our findings show no clear association between demographic or clinical data and existing reports on the malaria transmission intensity. The complete invasion data obtained for 156 isolates, showed the predominance of SA-independent pathways in Ghanaian clinical isolates. Isolates from Hohoe and Navrongo had the highest diversity in invasion profile. Our data also confirmed that the PfRh4-CR1 mediated alternative pathway is important in Ghanaian clinical isolates. Furthermore, the transcript levels of ten invasion-related genes obtained in the study showed little variations in gene expression profiles within and between parasite populations across sites.Our data suggest a low level of phenotypic diversity in Ghanaian clinical isolates across areas of varying endemicity and further highlight its importance in the quest for new intervention strategies, such as the investigation of blood-stage vaccine targets, particularly those targeting specific pathways and able to trigger the stimulation of broadly neutralizing invasion antibodies." @default.
• W4297000623 created "2022-09-25" @default.
• W4297000623 creator A5016342858 @default.
• W4297000623 creator A5024769478 @default.
• W4297000623 creator A5048891875 @default.
• W4297000623 creator A5055968153 @default.
• W4297000623 creator A5066808545 @default.
• W4297000623 creator A5084794344 @default.
• W4297000623 date "2022-09-23" @default.
• W4297000623 modified "2023-09-30" @default.
• W4297000623 title "Phenotypic characterization of Ghanaian P. falciparum clinical isolates reveals a homogenous parasite population" @default.
• W4297000623 cites W1974204803 @default.
• W4297000623 cites W1980121310 @default.
• W4297000623 cites W1985782539 @default.
• W4297000623 cites W2001563154 @default.
• W4297000623 cites W2017229434 @default.
• W4297000623 cites W2027834647 @default.
• W4297000623 cites W2033607108 @default.
• W4297000623 cites W2036558143 @default.
• W4297000623 cites W2042758260 @default.
• W4297000623 cites W2064591891 @default.
• W4297000623 cites W2070130804 @default.
• W4297000623 cites W2085020849 @default.
• W4297000623 cites W2093426037 @default.
• W4297000623 cites W2110968330 @default.
• W4297000623 cites W2122647378 @default.
• W4297000623 cites W2123770466 @default.
• W4297000623 cites W2132006513 @default.
• W4297000623 cites W2143467023 @default.
• W4297000623 cites W2147681153 @default.
• W4297000623 cites W2148712582 @default.
• W4297000623 cites W2153223219 @default.
• W4297000623 cites W2155332571 @default.
• W4297000623 cites W2156434765 @default.
• W4297000623 cites W2163660125 @default.
• W4297000623 cites W2269090040 @default.
• W4297000623 cites W2478088458 @default.
• W4297000623 cites W2607247991 @default.
• W4297000623 cites W2744245504 @default.
• W4297000623 cites W2798031204 @default.
• W4297000623 cites W3003984456 @default.
• W4297000623 cites W3143970748 @default.
• W4297000623 cites W4320288636 @default.
• W4297000623 doi "https://doi.org/10.3389/fimmu.2022.1009252" @default.
• W4297000623 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/36211335" @default.
• W4297000623 hasPublicationYear "2022" @default.
• W4297000623 type Work @default.
• W4297000623 citedByCount "0" @default.
• W4297000623 crossrefType "journal-article" @default.
• W4297000623 hasAuthorship W4297000623A5016342858 @default.
• W4297000623 hasAuthorship W4297000623A5024769478 @default.
• W4297000623 hasAuthorship W4297000623A5048891875 @default.
• W4297000623 hasAuthorship W4297000623A5055968153 @default.
• W4297000623 hasAuthorship W4297000623A5066808545 @default.
• W4297000623 hasAuthorship W4297000623A5084794344 @default.
• W4297000623 hasBestOaLocation W42970006231 @default.
• W4297000623 hasConcept C104317684 @default.
• W4297000623 hasConcept C11957725 @default.
• W4297000623 hasConcept C127716648 @default.
• W4297000623 hasConcept C136764020 @default.
• W4297000623 hasConcept C159047783 @default.
• W4297000623 hasConcept C203014093 @default.
• W4297000623 hasConcept C2776415932 @default.
• W4297000623 hasConcept C2778048844 @default.
• W4297000623 hasConcept C2778371730 @default.
• W4297000623 hasConcept C2780115458 @default.
• W4297000623 hasConcept C2908647359 @default.
• W4297000623 hasConcept C41008148 @default.
• W4297000623 hasConcept C54355233 @default.
• W4297000623 hasConcept C71924100 @default.
• W4297000623 hasConcept C71928629 @default.
• W4297000623 hasConcept C86803240 @default.
• W4297000623 hasConcept C99454951 @default.
• W4297000623 hasConceptScore W4297000623C104317684 @default.
• W4297000623 hasConceptScore W4297000623C11957725 @default.
• W4297000623 hasConceptScore W4297000623C127716648 @default.
• W4297000623 hasConceptScore W4297000623C136764020 @default.
• W4297000623 hasConceptScore W4297000623C159047783 @default.
• W4297000623 hasConceptScore W4297000623C203014093 @default.
• W4297000623 hasConceptScore W4297000623C2776415932 @default.
• W4297000623 hasConceptScore W4297000623C2778048844 @default.
• W4297000623 hasConceptScore W4297000623C2778371730 @default.
• W4297000623 hasConceptScore W4297000623C2780115458 @default.
• W4297000623 hasConceptScore W4297000623C2908647359 @default.
• W4297000623 hasConceptScore W4297000623C41008148 @default.
• W4297000623 hasConceptScore W4297000623C54355233 @default.
• W4297000623 hasConceptScore W4297000623C71924100 @default.
• W4297000623 hasConceptScore W4297000623C71928629 @default.
• W4297000623 hasConceptScore W4297000623C86803240 @default.
• W4297000623 hasConceptScore W4297000623C99454951 @default.
• W4297000623 hasFunder F4320307855 @default.
• W4297000623 hasFunder F4320311904 @default.
• W4297000623 hasLocation W42970006231 @default.
• W4297000623 hasLocation W42970006232 @default.
• W4297000623 hasLocation W42970006233 @default.
• W4297000623 hasLocation W42970006234 @default.
• W4297000623 hasLocation W42970006235 @default.
• W4297000623 hasOpenAccess W4297000623 @default.
• W4297000623 hasPrimaryLocation W42970006231 @default.
• W4297000623 hasRelatedWork W1497193691 @default.

• next