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• W4297000838 abstract "In drug discovery, molecular modification over the lead molecule is often crucial for the development of a drug. Herein, we report the molecular hybridization design of a novel RXPA380-proline hybrid via linking the parent compound, phosphinic peptide RXPA380, with a proline analogue. The presented synthetic route is straightforward and produces the desired product RXPA380-P in moderate yield. The C- and N-domain constructs of the angiotensin-converting enzyme of RXPA380-P appeared to be poor inhibitors of ACE as compared to the parent compound RXPA380." @default.
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• W4297000838 date "2022-09-23" @default.
• W4297000838 modified "2023-09-26" @default.
• W4297000838 title "Design, Synthesis, and Study of a Novel <b>RXPA380</b>–<b>Proline</b> Hybrid (<b>RXPA380-P</b>) as an Antihypertensive Agent" @default.
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• W4297000838 doi "https://doi.org/10.1021/acsomega.2c03813" @default.
• W4297000838 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/36211060" @default.
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