Matches in SemOpenAlex for { <https://semopenalex.org/work/W4297002149> ?p ?o ?g. }
Showing items 1 to 87 of
87
with 100 items per page.
- W4297002149 abstract "Cancer therapy-related cardiac dysfunction (CTRCD) is a challenging and life-threatening complication of many chemotherapeutic regimens. CTRCD prevention, diagnosis, and therapy require both careful interdisciplinary assessment and management. For patients with CTRCD, current guidelines of the European Society of Cardiology (ESC) recommend an angiotensin-converting-enzyme inhibitor in combination with a beta-blocker. Recent studies indicate a beneficial effect of sacubitril/valsartan in this patient population.A 68-year-old female patient with a pleural epithelioid angiosarcoma developed heart failure with reduced ejection fraction and elevated serum biomarkers following doxorubicin treatment. After implementation of a recommended cardioprotective medical therapy including torasemide, ramipril, carvedilol, and spironolactone, the patient suffered two cardiac decompensations within 4 weeks after initiation of a paclitaxel regimen and pleural radiation therapy due to pain exacerbation. Despite a continuous application of the cardioprotective medical treatment regimen, no improvement of left-ventricular ejection fraction (LVEF) was detected in a 4-month follow up. Interestingly, after omitting ramipril and implementing low-dose sacubitril/valsartan (26/24 mg), we observed a decrease in serum biomarkers within 3 months as well as a significant improvement of LVEF within 6 months. After nearly 10 months of disease stabilization under paclitaxel, the patient suffered progressive cancer disease and deceased 1 week later after the initiation of a therapeutic attempt with pazopanib.This case report highlights the importance of interdisciplinary care in cancer patients as well as the promising role of (low-dose) sacubitril/valsartan in patients with CTRCD even in the setting of delayed initiation." @default.
- W4297002149 created "2022-09-25" @default.
- W4297002149 creator A5006091584 @default.
- W4297002149 creator A5019051053 @default.
- W4297002149 creator A5060151897 @default.
- W4297002149 creator A5063753928 @default.
- W4297002149 date "2022-09-23" @default.
- W4297002149 modified "2023-10-14" @default.
- W4297002149 title "Successful treatment of doxorubicin-induced cardiomyopathy with low-dose sacubitril/valsartan: a case report" @default.
- W4297002149 cites W148860973 @default.
- W4297002149 cites W2427094903 @default.
- W4297002149 cites W2508734629 @default.
- W4297002149 cites W2800400752 @default.
- W4297002149 cites W2809947581 @default.
- W4297002149 cites W2967057696 @default.
- W4297002149 cites W2984567860 @default.
- W4297002149 cites W3004443876 @default.
- W4297002149 cites W3005517924 @default.
- W4297002149 cites W3012405276 @default.
- W4297002149 cites W3031292493 @default.
- W4297002149 cites W3037436886 @default.
- W4297002149 cites W3040275902 @default.
- W4297002149 cites W3097599730 @default.
- W4297002149 cites W3109417737 @default.
- W4297002149 cites W3193598686 @default.
- W4297002149 cites W4294605240 @default.
- W4297002149 doi "https://doi.org/10.1093/ehjcr/ytac396" @default.
- W4297002149 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/36267296" @default.
- W4297002149 hasPublicationYear "2022" @default.
- W4297002149 type Work @default.
- W4297002149 citedByCount "1" @default.
- W4297002149 countsByYear W42970021492023 @default.
- W4297002149 crossrefType "journal-article" @default.
- W4297002149 hasAuthorship W4297002149A5006091584 @default.
- W4297002149 hasAuthorship W4297002149A5019051053 @default.
- W4297002149 hasAuthorship W4297002149A5060151897 @default.
- W4297002149 hasAuthorship W4297002149A5063753928 @default.
- W4297002149 hasBestOaLocation W42970021491 @default.
- W4297002149 hasConcept C126322002 @default.
- W4297002149 hasConcept C164705383 @default.
- W4297002149 hasConcept C177713679 @default.
- W4297002149 hasConcept C2775999527 @default.
- W4297002149 hasConcept C2776694085 @default.
- W4297002149 hasConcept C2777387769 @default.
- W4297002149 hasConcept C2778198053 @default.
- W4297002149 hasConcept C2778233292 @default.
- W4297002149 hasConcept C2778797674 @default.
- W4297002149 hasConcept C2779888176 @default.
- W4297002149 hasConcept C2781413609 @default.
- W4297002149 hasConcept C71924100 @default.
- W4297002149 hasConcept C78085059 @default.
- W4297002149 hasConcept C84393581 @default.
- W4297002149 hasConceptScore W4297002149C126322002 @default.
- W4297002149 hasConceptScore W4297002149C164705383 @default.
- W4297002149 hasConceptScore W4297002149C177713679 @default.
- W4297002149 hasConceptScore W4297002149C2775999527 @default.
- W4297002149 hasConceptScore W4297002149C2776694085 @default.
- W4297002149 hasConceptScore W4297002149C2777387769 @default.
- W4297002149 hasConceptScore W4297002149C2778198053 @default.
- W4297002149 hasConceptScore W4297002149C2778233292 @default.
- W4297002149 hasConceptScore W4297002149C2778797674 @default.
- W4297002149 hasConceptScore W4297002149C2779888176 @default.
- W4297002149 hasConceptScore W4297002149C2781413609 @default.
- W4297002149 hasConceptScore W4297002149C71924100 @default.
- W4297002149 hasConceptScore W4297002149C78085059 @default.
- W4297002149 hasConceptScore W4297002149C84393581 @default.
- W4297002149 hasFunder F4320325136 @default.
- W4297002149 hasIssue "10" @default.
- W4297002149 hasLocation W42970021491 @default.
- W4297002149 hasLocation W42970021492 @default.
- W4297002149 hasLocation W42970021493 @default.
- W4297002149 hasOpenAccess W4297002149 @default.
- W4297002149 hasPrimaryLocation W42970021491 @default.
- W4297002149 hasRelatedWork W2334396920 @default.
- W4297002149 hasRelatedWork W2604998822 @default.
- W4297002149 hasRelatedWork W2789596123 @default.
- W4297002149 hasRelatedWork W2969101984 @default.
- W4297002149 hasRelatedWork W2989425857 @default.
- W4297002149 hasRelatedWork W3098968871 @default.
- W4297002149 hasRelatedWork W4229334242 @default.
- W4297002149 hasRelatedWork W4319600715 @default.
- W4297002149 hasRelatedWork W4324019008 @default.
- W4297002149 hasRelatedWork W4378648468 @default.
- W4297002149 hasVolume "6" @default.
- W4297002149 isParatext "false" @default.
- W4297002149 isRetracted "false" @default.
- W4297002149 workType "article" @default.