Matches in SemOpenAlex for { <https://semopenalex.org/work/W4297008788> ?p ?o ?g. }
- W4297008788 endingPage "3972" @default.
- W4297008788 startingPage "3972" @default.
- W4297008788 abstract "Various therapies for osteoporosis successfully reduce bone loss and fractures, but they mostly do not contribute to new bone structures and adversely affect patients. Shilajit is a natural mineral substance comprised of multi-components, with proved efficacy to improve immunity, antioxidant activity, and disease resistance. In the present study, various effects of shilajit water extract (SWE) on bone development and its management were determined in experimental glucocorticoid-induced osteoporotic rats. The fabrication of nanochitosan (NCT) and NCT conjugation with SWE were conducted and evaluated as enhanced formulations for treating osteoporosis. NCT and SWE/NCT had mean particle diameters of 196.4 and 248.4 nm, respectively, with high positivity charging and stability. The biochemical and anti-osteoporotic effects of SWE and SWE/NCT conjugates were investigated on different groups of compromised rats. Five groups each including six adult albino female rats were formed and treated for a duration of eight weeks with SWE and SWE/NCT conjugate. Significantly improved serum calcium, phosphorus, osteocalcin, and calcitonin levels but decreased hydrogen peroxide, IL-6, and antioxidant biomarkers were recorded in all SWE- and SWE/NCT-treated groups; the SWE/NCT treatment was most effectual treatment. These results suggest that SWE and SWE/NCT may cause anti-osteoporotic activity by reducing oxidative stress, IL-6, and H2O2 while restoring antioxidant levels. The conjugation of SWE onto NCT is highly recommended for augmenting their activities." @default.
- W4297008788 created "2022-09-25" @default.
- W4297008788 creator A5040277445 @default.
- W4297008788 creator A5068620198 @default.
- W4297008788 date "2022-09-23" @default.
- W4297008788 modified "2023-10-18" @default.
- W4297008788 title "Correlation between Antioxidant and Anti-Osteoporotic Activities of Shilajit Loaded into Chitosan Nanoparticles and Their Effects on Osteoporosis in Rats" @default.
- W4297008788 cites W1968306513 @default.
- W4297008788 cites W1992691926 @default.
- W4297008788 cites W2002081887 @default.
- W4297008788 cites W2004190331 @default.
- W4297008788 cites W2019463326 @default.
- W4297008788 cites W2022003744 @default.
- W4297008788 cites W2029757990 @default.
- W4297008788 cites W2032097545 @default.
- W4297008788 cites W2032905680 @default.
- W4297008788 cites W2045888895 @default.
- W4297008788 cites W2060107429 @default.
- W4297008788 cites W2066365078 @default.
- W4297008788 cites W2072951637 @default.
- W4297008788 cites W2074926636 @default.
- W4297008788 cites W2084910847 @default.
- W4297008788 cites W2102455595 @default.
- W4297008788 cites W2108279080 @default.
- W4297008788 cites W2110396808 @default.
- W4297008788 cites W2114760606 @default.
- W4297008788 cites W2117340681 @default.
- W4297008788 cites W2123076322 @default.
- W4297008788 cites W2133947803 @default.
- W4297008788 cites W2417995089 @default.
- W4297008788 cites W2469488029 @default.
- W4297008788 cites W2785881131 @default.
- W4297008788 cites W2793485037 @default.
- W4297008788 cites W2803000067 @default.
- W4297008788 cites W2883821363 @default.
- W4297008788 cites W2907892151 @default.
- W4297008788 cites W2913940361 @default.
- W4297008788 cites W2915026764 @default.
- W4297008788 cites W2920103345 @default.
- W4297008788 cites W3039169002 @default.
- W4297008788 cites W3116109709 @default.
- W4297008788 cites W3144419394 @default.
- W4297008788 cites W3144695097 @default.
- W4297008788 cites W3165358345 @default.
- W4297008788 cites W3181115530 @default.
- W4297008788 cites W3205292488 @default.
- W4297008788 cites W4206338835 @default.
- W4297008788 cites W4280601129 @default.
- W4297008788 cites W4282920389 @default.
- W4297008788 cites W4287843352 @default.
- W4297008788 cites W92676014 @default.
- W4297008788 doi "https://doi.org/10.3390/polym14193972" @default.
- W4297008788 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/36235920" @default.
- W4297008788 hasPublicationYear "2022" @default.
- W4297008788 type Work @default.
- W4297008788 citedByCount "1" @default.
- W4297008788 countsByYear W42970087882023 @default.
- W4297008788 crossrefType "journal-article" @default.
- W4297008788 hasAuthorship W4297008788A5040277445 @default.
- W4297008788 hasAuthorship W4297008788A5068620198 @default.
- W4297008788 hasBestOaLocation W42970087881 @default.
- W4297008788 hasConcept C126322002 @default.
- W4297008788 hasConcept C185592680 @default.
- W4297008788 hasConcept C199343813 @default.
- W4297008788 hasConcept C2776151105 @default.
- W4297008788 hasConcept C2776541429 @default.
- W4297008788 hasConcept C2778004101 @default.
- W4297008788 hasConcept C2779627488 @default.
- W4297008788 hasConcept C55493867 @default.
- W4297008788 hasConcept C71924100 @default.
- W4297008788 hasConceptScore W4297008788C126322002 @default.
- W4297008788 hasConceptScore W4297008788C185592680 @default.
- W4297008788 hasConceptScore W4297008788C199343813 @default.
- W4297008788 hasConceptScore W4297008788C2776151105 @default.
- W4297008788 hasConceptScore W4297008788C2776541429 @default.
- W4297008788 hasConceptScore W4297008788C2778004101 @default.
- W4297008788 hasConceptScore W4297008788C2779627488 @default.
- W4297008788 hasConceptScore W4297008788C55493867 @default.
- W4297008788 hasConceptScore W4297008788C71924100 @default.
- W4297008788 hasFunder F4320322322 @default.
- W4297008788 hasIssue "19" @default.
- W4297008788 hasLocation W42970087881 @default.
- W4297008788 hasLocation W42970087882 @default.
- W4297008788 hasLocation W42970087883 @default.
- W4297008788 hasLocation W42970087884 @default.
- W4297008788 hasOpenAccess W4297008788 @default.
- W4297008788 hasPrimaryLocation W42970087881 @default.
- W4297008788 hasRelatedWork W1976026154 @default.
- W4297008788 hasRelatedWork W1989332506 @default.
- W4297008788 hasRelatedWork W2026822609 @default.
- W4297008788 hasRelatedWork W2039630961 @default.
- W4297008788 hasRelatedWork W2107802390 @default.
- W4297008788 hasRelatedWork W2365591866 @default.
- W4297008788 hasRelatedWork W2748952813 @default.
- W4297008788 hasRelatedWork W2791181644 @default.
- W4297008788 hasRelatedWork W2899084033 @default.
- W4297008788 hasRelatedWork W2050330784 @default.
- W4297008788 hasVolume "14" @default.