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• W4297010281 abstract "The cardiovascular protection effect of metformin on patients with type 2 diabetes mellitus (T2DM) remains inconclusive. This systemic review and meta-analysis were to estimate the effect of metformin on mortality and cardiovascular events among patients with T2DM.A search of the Pubmed and EMBASE databases up to December 2021 was performed. Adjusted hazard ratios (HRs) and 95% confidence intervals (CIs) were pooled by a random-effects model with an inverse variance method.A total of 39 studies involving 2473009 T2DM patients were adopted. Compared to non-metformin therapy, the use of metformin was not significantly associated with a reduced risk of major adverse cardiovascular event (MACE) (HR = 1.06, 95%CI 0.91-1.22; I2 = 82%), hospitalization (HR = 0.85, 95%CI 0.64-1.13; I2 = 98%), heart failure (HR = 0.86, 95%CI 0.60-1.25; I2 = 99%), stroke (HR = 1.16, 95%CI 0.88-1.53; I2 = 84%), and risk of AMI (HR = 0.88, 95%CI 0.69-1.14; I2 = 88%) in T2DM patients. Metformin was also not associated with significantly lowered risk of MACE compared to dipeptidyl peptidase-4 inhibitor (DPP-4i) in T2DM patients (HR = 0.95, 95%CI 0.73-1.23; I2 = 84%).The effect of metformin on some cardiovascular outcomes was not significantly better than the non-metformin therapy or DPP-4i in T2DM patients based on observational studies." @default.
• W4297010281 created "2022-09-25" @default.
• W4297010281 creator A5042888832 @default.
• W4297010281 creator A5055058138 @default.
• W4297010281 creator A5057708781 @default.
• W4297010281 creator A5080814061 @default.
• W4297010281 creator A5091511286 @default.
• W4297010281 date "2022-09-23" @default.
• W4297010281 modified "2023-10-18" @default.
• W4297010281 title "Effect of metformin on adverse outcomes in T2DM patients: Systemic review and meta-analysis of observational studies" @default.
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