FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4297020338> ?p ?o ?g. }

• W4297020338 abstract "Abstract Sarcopenia has become a leading cause of disability and mortality in the elderly. Decreased size and loss of the number of skeletal muscle cells are the histological manifestations of sarcopenia. Increasing evidence shows that programmed cell death (PCD) contributes to the loss of skeletal muscle fibers. TNF-α is also validated to play a prominent role in sarcopenia through its complex signaling pathways including cell death signaling. However, it is unclear whether TNF-α contributes to sarcopenia by mediating pyroptosis which is one type of PCD. Here, we first established naturally aged mice with sarcopenia model and confirmed an inflammatory state represented by TNF-α in aged mice. Evidence of GSDME-mediated pyroptosis and activation of apoptotic caspase-8/-3 were further found in skeletal muscle cells. We demonstrated that TNF-α triggered GSDME-mediated pyroptosis in myotubes through activating caspase-8 and caspase-3 by using caspase-8 and caspase-3 inhibitors. Comparing the activation of caspase-8 and GSDME expression between TNF Complex IIa and TNF Complex IIb, TNF-α was more inclined to assemble TNF Complex IIb in activating caspase-8 and triggering pyroptosis. Moreover, pyroptotic myotubes were validated to result in decreased expression of MHC1 and finally loss of myotubes by knockdown of GSDME. Our work unravels a novel mechanism that TNF-ɑ/caspase-8/caspase-3/GSDME signaling-mediated pyroptosis plays a pathogenic role in the development of sarcopenia. caspase-3/GSDME signaling-mediated pyroptosis can be a promising therapeutic target for sarcopenia." @default.
• W4297020338 created "2022-09-25" @default.
• W4297020338 creator A5001048473 @default.
• W4297020338 creator A5001453496 @default.
• W4297020338 creator A5020099759 @default.
• W4297020338 creator A5022275537 @default.
• W4297020338 creator A5032227108 @default.
• W4297020338 creator A5041728952 @default.
• W4297020338 creator A5045848195 @default.
• W4297020338 creator A5060057579 @default.
• W4297020338 creator A5064115274 @default.
• W4297020338 creator A5070854688 @default.
• W4297020338 date "2022-09-23" @default.
• W4297020338 modified "2023-09-27" @default.
• W4297020338 title "TNF-α contributes to sarcopenia through caspase-8/caspase-3/GSDME-mediated pyroptosis" @default.
• W4297020338 cites W1539477086 @default.
• W4297020338 cites W1572664742 @default.
• W4297020338 cites W1965927192 @default.
• W4297020338 cites W2018746638 @default.
• W4297020338 cites W2045984402 @default.
• W4297020338 cites W2054561000 @default.
• W4297020338 cites W2064242048 @default.
• W4297020338 cites W2126525177 @default.
• W4297020338 cites W2130025116 @default.
• W4297020338 cites W2218984780 @default.
• W4297020338 cites W2555126138 @default.
• W4297020338 cites W2564122215 @default.
• W4297020338 cites W2586409557 @default.
• W4297020338 cites W2608687752 @default.
• W4297020338 cites W2627048017 @default.
• W4297020338 cites W2808004437 @default.
• W4297020338 cites W2884048133 @default.
• W4297020338 cites W2895833591 @default.
• W4297020338 cites W2897513125 @default.
• W4297020338 cites W2903440643 @default.
• W4297020338 cites W2911789924 @default.
• W4297020338 cites W2936083981 @default.
• W4297020338 cites W2951509935 @default.
• W4297020338 cites W2977165675 @default.
• W4297020338 cites W2983652778 @default.
• W4297020338 cites W3033199665 @default.
• W4297020338 cites W3056755428 @default.
• W4297020338 cites W3082555410 @default.
• W4297020338 cites W3095202855 @default.
• W4297020338 cites W3095477849 @default.
• W4297020338 cites W3101261873 @default.
• W4297020338 cites W3108240984 @default.
• W4297020338 cites W3113059059 @default.
• W4297020338 cites W3127045384 @default.
• W4297020338 cites W3134454558 @default.
• W4297020338 cites W3180792069 @default.
• W4297020338 cites W3185015670 @default.
• W4297020338 cites W3213407578 @default.
• W4297020338 cites W3213473175 @default.
• W4297020338 doi "https://doi.org/10.21203/rs.3.rs-2032585/v1" @default.
• W4297020338 hasPublicationYear "2022" @default.
• W4297020338 type Work @default.
• W4297020338 citedByCount "0" @default.
• W4297020338 crossrefType "posted-content" @default.
• W4297020338 hasAuthorship W4297020338A5001048473 @default.
• W4297020338 hasAuthorship W4297020338A5001453496 @default.
• W4297020338 hasAuthorship W4297020338A5020099759 @default.
• W4297020338 hasAuthorship W4297020338A5022275537 @default.
• W4297020338 hasAuthorship W4297020338A5032227108 @default.
• W4297020338 hasAuthorship W4297020338A5041728952 @default.
• W4297020338 hasAuthorship W4297020338A5045848195 @default.
• W4297020338 hasAuthorship W4297020338A5060057579 @default.
• W4297020338 hasAuthorship W4297020338A5064115274 @default.
• W4297020338 hasAuthorship W4297020338A5070854688 @default.
• W4297020338 hasBestOaLocation W42970203381 @default.
• W4297020338 hasConcept C134018914 @default.
• W4297020338 hasConcept C17172800 @default.
• W4297020338 hasConcept C190283241 @default.
• W4297020338 hasConcept C207200792 @default.
• W4297020338 hasConcept C2776214593 @default.
• W4297020338 hasConcept C2779959927 @default.
• W4297020338 hasConcept C31573885 @default.
• W4297020338 hasConcept C3763915 @default.
• W4297020338 hasConcept C48297814 @default.
• W4297020338 hasConcept C502942594 @default.
• W4297020338 hasConcept C55493867 @default.
• W4297020338 hasConcept C86803240 @default.
• W4297020338 hasConcept C95444343 @default.
• W4297020338 hasConcept C98424977 @default.
• W4297020338 hasConceptScore W4297020338C134018914 @default.
• W4297020338 hasConceptScore W4297020338C17172800 @default.
• W4297020338 hasConceptScore W4297020338C190283241 @default.
• W4297020338 hasConceptScore W4297020338C207200792 @default.
• W4297020338 hasConceptScore W4297020338C2776214593 @default.
• W4297020338 hasConceptScore W4297020338C2779959927 @default.
• W4297020338 hasConceptScore W4297020338C31573885 @default.
• W4297020338 hasConceptScore W4297020338C3763915 @default.
• W4297020338 hasConceptScore W4297020338C48297814 @default.
• W4297020338 hasConceptScore W4297020338C502942594 @default.
• W4297020338 hasConceptScore W4297020338C55493867 @default.
• W4297020338 hasConceptScore W4297020338C86803240 @default.
• W4297020338 hasConceptScore W4297020338C95444343 @default.
• W4297020338 hasConceptScore W4297020338C98424977 @default.
• W4297020338 hasLocation W42970203381 @default.
• W4297020338 hasLocation W42970203382 @default.

• next