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• W4297092788 abstract "Steroid hormones perform diverse biological functions in developing and adult animals. However, the mechanistic basis for their tissue specificity remains unclear. In Drosophila , the ecdysone steroid hormone is essential for coordinating developmental timing across physically separated tissues. Ecdysone directly impacts genome function through its nuclear receptor, a heterodimer of the EcR and ultraspiracle proteins. Ligand binding to EcR triggers a transcriptional cascade, including activation of a set of primary response transcription factors. The hierarchical organization of this pathway has left the direct role of EcR in mediating ecdysone responses obscured. Here, we investigate the role of EcR in controlling tissue-specific ecdysone responses, focusing on two tissues that diverge in their response to rising ecdysone titers: the larval salivary gland, which undergoes programmed destruction, and the wing imaginal disc, which initiates morphogenesis. We find that EcR functions bimodally, with both gene repressive and activating functions, even at the same developmental stage. EcR DNA binding profiles are highly tissue-specific, and transgenic reporter analyses demonstrate that EcR plays a direct role in controlling enhancer activity. Finally, despite a strong correlation between tissue-specific EcR binding and tissue-specific open chromatin, we find that EcR does not control chromatin accessibility at genomic targets. We conclude that EcR contributes extensively to tissue-specific ecdysone responses. However, control over access to its binding sites is subordinated to other transcription factors." @default.
• W4297092788 created "2022-09-27" @default.
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• W4297092788 date "2022-09-26" @default.
• W4297092788 modified "2023-10-05" @default.
• W4297092788 title "Opportunistic binding of EcR to open chromatin drives tissue-specific developmental responses" @default.
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• W4297092788 doi "https://doi.org/10.1073/pnas.2208935119" @default.
• W4297092788 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/36161884" @default.
• W4297092788 hasPublicationYear "2022" @default.
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