Matches in SemOpenAlex for { <https://semopenalex.org/work/W4297094176> ?p ?o ?g. }
Showing items 1 to 100 of
100
with 100 items per page.
- W4297094176 endingPage "614" @default.
- W4297094176 startingPage "603" @default.
- W4297094176 abstract "Maternal stress during pregnancy results in increased risk of developing psychiatric disorders in the offspring including anxiety, depression, schizophrenia, and autism. However, the mechanisms underlying this disease susceptibility remain largely to be determined. In this study, the involvement of the serotonin (5-HT) and kynurenine (KYN) pathways of tryptophan metabolism on the behavioral deficits induced by maternal stress during the late phase of gestation in mice was investigated. Adult offspring born to control or restraint-stressed dams were exposed to the elevated plus-maze and tail suspension tests. Metabolites of the KYN and 5-HT pathways were measured in the hippocampus and brainstem by ultra-performance liquid chromatography tandem mass spectrometry. Female, but not male, prenatally stressed (PNS) offspring displayed a depressive-like phenotype, mainly when in proestrus/diestrus, along with reduced hippocampal 5-HT levels and high 5-HT turnover rate in the hippocampus and brainstem. In contrast, male PNS mice showed enhanced anxiety-like behaviors and higher hippocampal and brainstem quinolinic acid levels compared to male offspring born to nonstressed dams. These results indicate that maternal stress affects the behavior and brain metabolism of tryptophan in the offspring in a sex-dependent manner and suggest that alterations in both the 5-HT and KYN pathways may underlie the emotional dysfunctions observed in individuals exposed to stress during in utero development." @default.
- W4297094176 created "2022-09-27" @default.
- W4297094176 creator A5008175400 @default.
- W4297094176 creator A5012013743 @default.
- W4297094176 creator A5019908512 @default.
- W4297094176 creator A5023584911 @default.
- W4297094176 creator A5043979251 @default.
- W4297094176 creator A5057857422 @default.
- W4297094176 creator A5066807551 @default.
- W4297094176 creator A5071168732 @default.
- W4297094176 creator A5075899873 @default.
- W4297094176 creator A5084409231 @default.
- W4297094176 date "2022-01-01" @default.
- W4297094176 modified "2023-10-12" @default.
- W4297094176 title "Maternal Stress during Pregnancy in Mice Induces Sex-Dependent Behavioral Alterations in Offspring along with Impaired Serotonin and Kynurenine Pathways of Tryptophan Metabolism" @default.
- W4297094176 doi "https://doi.org/10.1159/000526647" @default.
- W4297094176 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/36162387" @default.
- W4297094176 hasPublicationYear "2022" @default.
- W4297094176 type Work @default.
- W4297094176 citedByCount "2" @default.
- W4297094176 countsByYear W42970941762023 @default.
- W4297094176 crossrefType "journal-article" @default.
- W4297094176 hasAuthorship W4297094176A5008175400 @default.
- W4297094176 hasAuthorship W4297094176A5012013743 @default.
- W4297094176 hasAuthorship W4297094176A5019908512 @default.
- W4297094176 hasAuthorship W4297094176A5023584911 @default.
- W4297094176 hasAuthorship W4297094176A5043979251 @default.
- W4297094176 hasAuthorship W4297094176A5057857422 @default.
- W4297094176 hasAuthorship W4297094176A5066807551 @default.
- W4297094176 hasAuthorship W4297094176A5071168732 @default.
- W4297094176 hasAuthorship W4297094176A5075899873 @default.
- W4297094176 hasAuthorship W4297094176A5084409231 @default.
- W4297094176 hasConcept C112672928 @default.
- W4297094176 hasConcept C118552586 @default.
- W4297094176 hasConcept C126322002 @default.
- W4297094176 hasConcept C134018914 @default.
- W4297094176 hasConcept C148762608 @default.
- W4297094176 hasConcept C15744967 @default.
- W4297094176 hasConcept C170493617 @default.
- W4297094176 hasConcept C173586616 @default.
- W4297094176 hasConcept C2775864247 @default.
- W4297094176 hasConcept C2776706248 @default.
- W4297094176 hasConcept C2776710720 @default.
- W4297094176 hasConcept C2777503454 @default.
- W4297094176 hasConcept C2777896816 @default.
- W4297094176 hasConcept C2779234561 @default.
- W4297094176 hasConcept C2780352252 @default.
- W4297094176 hasConcept C2781161787 @default.
- W4297094176 hasConcept C515207424 @default.
- W4297094176 hasConcept C54355233 @default.
- W4297094176 hasConcept C55493867 @default.
- W4297094176 hasConcept C558461103 @default.
- W4297094176 hasConcept C71315377 @default.
- W4297094176 hasConcept C71924100 @default.
- W4297094176 hasConcept C86803240 @default.
- W4297094176 hasConceptScore W4297094176C112672928 @default.
- W4297094176 hasConceptScore W4297094176C118552586 @default.
- W4297094176 hasConceptScore W4297094176C126322002 @default.
- W4297094176 hasConceptScore W4297094176C134018914 @default.
- W4297094176 hasConceptScore W4297094176C148762608 @default.
- W4297094176 hasConceptScore W4297094176C15744967 @default.
- W4297094176 hasConceptScore W4297094176C170493617 @default.
- W4297094176 hasConceptScore W4297094176C173586616 @default.
- W4297094176 hasConceptScore W4297094176C2775864247 @default.
- W4297094176 hasConceptScore W4297094176C2776706248 @default.
- W4297094176 hasConceptScore W4297094176C2776710720 @default.
- W4297094176 hasConceptScore W4297094176C2777503454 @default.
- W4297094176 hasConceptScore W4297094176C2777896816 @default.
- W4297094176 hasConceptScore W4297094176C2779234561 @default.
- W4297094176 hasConceptScore W4297094176C2780352252 @default.
- W4297094176 hasConceptScore W4297094176C2781161787 @default.
- W4297094176 hasConceptScore W4297094176C515207424 @default.
- W4297094176 hasConceptScore W4297094176C54355233 @default.
- W4297094176 hasConceptScore W4297094176C55493867 @default.
- W4297094176 hasConceptScore W4297094176C558461103 @default.
- W4297094176 hasConceptScore W4297094176C71315377 @default.
- W4297094176 hasConceptScore W4297094176C71924100 @default.
- W4297094176 hasConceptScore W4297094176C86803240 @default.
- W4297094176 hasIssue "6" @default.
- W4297094176 hasLocation W42970941761 @default.
- W4297094176 hasLocation W42970941762 @default.
- W4297094176 hasLocation W42970941763 @default.
- W4297094176 hasOpenAccess W4297094176 @default.
- W4297094176 hasPrimaryLocation W42970941761 @default.
- W4297094176 hasRelatedWork W2104241569 @default.
- W4297094176 hasRelatedWork W2187650897 @default.
- W4297094176 hasRelatedWork W2209613548 @default.
- W4297094176 hasRelatedWork W2372817497 @default.
- W4297094176 hasRelatedWork W2732084948 @default.
- W4297094176 hasRelatedWork W2809585370 @default.
- W4297094176 hasRelatedWork W2912785417 @default.
- W4297094176 hasRelatedWork W2946317806 @default.
- W4297094176 hasRelatedWork W4308123922 @default.
- W4297094176 hasRelatedWork W4316813225 @default.
- W4297094176 hasVolume "44" @default.
- W4297094176 isParatext "false" @default.
- W4297094176 isRetracted "false" @default.
- W4297094176 workType "article" @default.