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• W4297097691 endingPage "983" @default.
• W4297097691 startingPage "976" @default.
• W4297097691 abstract "We examined individual differences in CD4/CD8 T-cell ratio trajectories and associated risk profiles from acute HIV infection (AHI) through 144 weeks of antiretroviral therapy (ART) using a data-driven approach.A total of 483 AHI participants began ART during Fiebig I-V and completed follow-up evaluations for 144 weeks. CD4+, CD8+, and CD4/CD8 T-cell ratio trajectories were defined followed by analyses to identify associated risk variables.Participants had a median viral load (VL) of 5.88 copies/ml and CD4/CD8 T-cell ratio of 0.71 at enrollment. After 144 weeks of ART, the median CD4/CD8 T-cell ratio was 1.3. Longitudinal models revealed five CD4/CD8 T-cell ratio subgroups: group 1 (3%) exhibited a ratio >1.0 at all visits; groups 2 (18%) and 3 (29%) exhibited inversion at enrollment, with normalization 4 and 12 weeks after ART, respectively; and groups 4 (31%) and 5 (18%) experienced CD4/CD8 T-cell ratio inversion due to slow CD4+ T-cell recovery (group 4) or high CD8+ T-cell count (group 5). Persistent inversion corresponded to ART onset after Fiebig II, higher VL, soluble CD27 and TIM-3, and lower eosinophil count. Individuals with slow CD4+ T-cell recovery exhibited higher VL, lower white blood cell count, lower basophil percent, and treatment with standard ART, as well as worse mental health and cognition, compared with individuals with high CD8+ T-cell count.Early HIV disease dynamics predict unfavorable CD4/CD8 T-cell ratio outcomes after ART. CD4+ and CD8+ T-cell trajectories contribute to inversion risk and correspond to specific viral, immune, and psychological profiles during AHI. Adjunctive strategies to achieve immune normalization merit consideration." @default.
• W4297097691 created "2022-09-27" @default.
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• W4297097691 date "2022-07-06" @default.
• W4297097691 modified "2023-10-16" @default.
• W4297097691 title "Individual Differences in CD4/CD8 T-Cell Ratio Trajectories and Associated Risk Profiles Modeled From Acute HIV Infection" @default.
• W4297097691 cites W1567036161 @default.
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• W4297097691 cites W1995570498 @default.
• W4297097691 cites W1998353416 @default.
• W4297097691 cites W2010298035 @default.
• W4297097691 cites W2017520700 @default.
• W4297097691 cites W2017740631 @default.
• W4297097691 cites W2018119542 @default.
• W4297097691 cites W2021905358 @default.
• W4297097691 cites W2031030014 @default.
• W4297097691 cites W2043671490 @default.
• W4297097691 cites W2053066952 @default.
• W4297097691 cites W2053252472 @default.
• W4297097691 cites W2055241434 @default.
• W4297097691 cites W2065148379 @default.
• W4297097691 cites W2072122526 @default.
• W4297097691 cites W2085643863 @default.
• W4297097691 cites W2095475275 @default.
• W4297097691 cites W2096634018 @default.
• W4297097691 cites W2108451834 @default.
• W4297097691 cites W2121710990 @default.
• W4297097691 cites W2121971846 @default.
• W4297097691 cites W2126141460 @default.
• W4297097691 cites W2129888542 @default.
• W4297097691 cites W2132322340 @default.
• W4297097691 cites W2144248766 @default.
• W4297097691 cites W2145476394 @default.
• W4297097691 cites W2148452875 @default.
• W4297097691 cites W2169319632 @default.
• W4297097691 cites W2191541939 @default.
• W4297097691 cites W2194524147 @default.
• W4297097691 cites W2230384494 @default.
• W4297097691 cites W2281358660 @default.
• W4297097691 cites W2396211956 @default.
• W4297097691 cites W2417926799 @default.
• W4297097691 cites W2418461762 @default.
• W4297097691 cites W2537229494 @default.
• W4297097691 cites W2567738426 @default.
• W4297097691 cites W2612080295 @default.
• W4297097691 cites W2766546668 @default.
• W4297097691 cites W2803371689 @default.
• W4297097691 cites W2888252014 @default.
• W4297097691 cites W2893997712 @default.
• W4297097691 cites W2898683220 @default.
• W4297097691 cites W2903278710 @default.
• W4297097691 cites W2963874185 @default.
• W4297097691 cites W2985806931 @default.
• W4297097691 cites W2997112610 @default.
• W4297097691 cites W3001389296 @default.
• W4297097691 cites W3009891155 @default.
• W4297097691 cites W3013374572 @default.
• W4297097691 cites W3014739436 @default.
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• W4297097691 doi "https://doi.org/10.1097/psy.0000000000001129" @default.
• W4297097691 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/36162059" @default.
• W4297097691 hasPublicationYear "2022" @default.
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