Matches in SemOpenAlex for { <https://semopenalex.org/work/W4297103585> ?p ?o ?g. }
- W4297103585 abstract "Abstract Mesenchymal stromal cells (MSCs) administered intravenously (IV) have shown efficacy in pre-clinical models of various diseases. This is despite the cells not reaching the site of injury due to entrapment in the lungs. The ability of MSCs to modulate immune responses has been proposed as one of the mechanisms by which these cells provide therapeutic benefits, irrespective of whether they are sourced from bone marrow, adipose tissue or umbilical cord. To better understand how MSCs affect innate immune cell populations in the lung, we evaluated the percentage, distribution and phenotype of neutrophils, monocytes and macrophages by flow cytometry and histological analyses after delivering human umbilical cord-derived MSCs (hUC-MSCs) IV into immunocompetent mice. After 2 h, we observed a sharp increase in neutrophils, and pro-inflammatory monocytes and macrophages. Moreover, these immune cells localised in the vicinity of the MSCs suggesting an active role in their clearance. By 24 h, we detected an increase in anti-inflammatory monocytes and macrophages. These results suggest that the IV injection of hUC-MSCs leads to an initial inflammatory phase in the lung shortly after injection, followed by a resolution phase 24 h later." @default.
- W4297103585 created "2022-09-27" @default.
- W4297103585 creator A5033946980 @default.
- W4297103585 creator A5046706740 @default.
- W4297103585 creator A5050429399 @default.
- W4297103585 creator A5089790546 @default.
- W4297103585 date "2022-09-26" @default.
- W4297103585 modified "2023-10-01" @default.
- W4297103585 title "Intravenous administration of human umbilical cord mesenchymal stromal cells leads to an inflammatory response in the lung" @default.
- W4297103585 cites W1508798545 @default.
- W4297103585 cites W1555995655 @default.
- W4297103585 cites W1856995660 @default.
- W4297103585 cites W1928621728 @default.
- W4297103585 cites W1958303027 @default.
- W4297103585 cites W1964060084 @default.
- W4297103585 cites W1971218073 @default.
- W4297103585 cites W1994494995 @default.
- W4297103585 cites W2001147904 @default.
- W4297103585 cites W2021916724 @default.
- W4297103585 cites W2040662877 @default.
- W4297103585 cites W2045701198 @default.
- W4297103585 cites W2045862134 @default.
- W4297103585 cites W2055224823 @default.
- W4297103585 cites W2080206255 @default.
- W4297103585 cites W2084519086 @default.
- W4297103585 cites W2100293996 @default.
- W4297103585 cites W2116257528 @default.
- W4297103585 cites W2129716877 @default.
- W4297103585 cites W2130071222 @default.
- W4297103585 cites W2132967213 @default.
- W4297103585 cites W2133724294 @default.
- W4297103585 cites W2134070522 @default.
- W4297103585 cites W2139167732 @default.
- W4297103585 cites W2154434805 @default.
- W4297103585 cites W2186373311 @default.
- W4297103585 cites W2282900725 @default.
- W4297103585 cites W2337861353 @default.
- W4297103585 cites W2468168745 @default.
- W4297103585 cites W2508710172 @default.
- W4297103585 cites W2551287343 @default.
- W4297103585 cites W2578577556 @default.
- W4297103585 cites W2587794239 @default.
- W4297103585 cites W2593148326 @default.
- W4297103585 cites W2612854279 @default.
- W4297103585 cites W2621945653 @default.
- W4297103585 cites W2730792888 @default.
- W4297103585 cites W2743794466 @default.
- W4297103585 cites W2762816177 @default.
- W4297103585 cites W2769010773 @default.
- W4297103585 cites W2782959446 @default.
- W4297103585 cites W2789450435 @default.
- W4297103585 cites W2791016534 @default.
- W4297103585 cites W2793366964 @default.
- W4297103585 cites W2902275158 @default.
- W4297103585 cites W2911559437 @default.
- W4297103585 cites W2913905282 @default.
- W4297103585 cites W2926345669 @default.
- W4297103585 cites W2935614541 @default.
- W4297103585 cites W2942690674 @default.
- W4297103585 cites W2946059227 @default.
- W4297103585 cites W2948595431 @default.
- W4297103585 cites W2975592443 @default.
- W4297103585 cites W3008240165 @default.
- W4297103585 cites W3015080429 @default.
- W4297103585 cites W3026927696 @default.
- W4297103585 cites W3044491460 @default.
- W4297103585 cites W3049480209 @default.
- W4297103585 cites W3100110852 @default.
- W4297103585 cites W3126766007 @default.
- W4297103585 cites W3138678559 @default.
- W4297103585 cites W3164313225 @default.
- W4297103585 cites W3212910602 @default.
- W4297103585 cites W4240398962 @default.
- W4297103585 cites W4241723693 @default.
- W4297103585 doi "https://doi.org/10.1101/2022.09.26.509547" @default.
- W4297103585 hasPublicationYear "2022" @default.
- W4297103585 type Work @default.
- W4297103585 citedByCount "1" @default.
- W4297103585 countsByYear W42971035852023 @default.
- W4297103585 crossrefType "posted-content" @default.
- W4297103585 hasAuthorship W4297103585A5033946980 @default.
- W4297103585 hasAuthorship W4297103585A5046706740 @default.
- W4297103585 hasAuthorship W4297103585A5050429399 @default.
- W4297103585 hasAuthorship W4297103585A5089790546 @default.
- W4297103585 hasBestOaLocation W42971035851 @default.
- W4297103585 hasConcept C126322002 @default.
- W4297103585 hasConcept C136449434 @default.
- W4297103585 hasConcept C142724271 @default.
- W4297103585 hasConcept C16930146 @default.
- W4297103585 hasConcept C171089720 @default.
- W4297103585 hasConcept C198826908 @default.
- W4297103585 hasConcept C203014093 @default.
- W4297103585 hasConcept C2776914184 @default.
- W4297103585 hasConcept C2776955114 @default.
- W4297103585 hasConcept C2777714996 @default.
- W4297103585 hasConcept C2780007613 @default.
- W4297103585 hasConcept C2781184567 @default.
- W4297103585 hasConcept C553184892 @default.
- W4297103585 hasConcept C71924100 @default.
- W4297103585 hasConcept C8891405 @default.