FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4297106246> ?p ?o ?g. }

• W4297106246 endingPage "15" @default.
• W4297106246 startingPage "1" @default.
• W4297106246 abstract "Triple-negative breast cancer (TNBC) has the highest percentage of lymphocytic infiltration among breast cancer subtypes, and TNBC patients may benefit from anti-PD-1/PD-L1 immunotherapy. However, some cases whether the immune checkpoint blockade (ICB) shows low targeting efficiency have occurred and effective synergistic targets need to be found, which inspired our exploration of the co-expression analysis of MCT4 (SLC16A3) and PD-L1 (CD274) and their potential regulatory mechanisms. After bioinformatic analysis of the relationship between MCT4 and PD-L1, we validated their positive co-expression relationship in triple-negative breast cancer through multiple immunohistochemical staining (mIHC), CRISPR/Cas9, and lentiviral transduction for MCT4 knockout (sgMCT4/231 KO) or overexpression (pEGFP-N1-MCT4/231). We examined the effect of lactate treatment on PD-L1 expression in triple-negative breast cancer cells by qRT-PCR and Western blot. Combined with our results, we found that MCT4 positively regulated PD-L1 expression through discharging lactate and stabilized PD-L1 through promoting its glycosylation by the classic WNT pathway in MDA-MB-231 cells. More importantly, the high co-expression of MCT4 and PD-L1 appears to predict more effective targets for treating TNBC, which would improve immune checkpoint therapy for TNBC." @default.
• W4297106246 created "2022-09-27" @default.
• W4297106246 creator A5002578550 @default.
• W4297106246 creator A5031810848 @default.
• W4297106246 creator A5031965105 @default.
• W4297106246 creator A5045335829 @default.
• W4297106246 creator A5049270203 @default.
• W4297106246 creator A5054493580 @default.
• W4297106246 creator A5063457276 @default.
• W4297106246 creator A5065506624 @default.
• W4297106246 creator A5073022247 @default.
• W4297106246 creator A5075098016 @default.
• W4297106246 creator A5075689150 @default.
• W4297106246 date "2022-09-26" @default.
• W4297106246 modified "2023-10-15" @default.
• W4297106246 title "MCT4/Lactate Promotes PD-L1 Glycosylation in Triple-Negative Breast Cancer Cells" @default.
• W4297106246 cites W1139261911 @default.
• W4297106246 cites W1599113903 @default.
• W4297106246 cites W1971779983 @default.
• W4297106246 cites W1997722072 @default.
• W4297106246 cites W2009208244 @default.
• W4297106246 cites W2013982760 @default.
• W4297106246 cites W2040789365 @default.
• W4297106246 cites W2047178318 @default.
• W4297106246 cites W2057186227 @default.
• W4297106246 cites W2063632665 @default.
• W4297106246 cites W2069809499 @default.
• W4297106246 cites W2084291827 @default.
• W4297106246 cites W2097259163 @default.
• W4297106246 cites W2100413206 @default.
• W4297106246 cites W2110015442 @default.
• W4297106246 cites W2159937179 @default.
• W4297106246 cites W2184384535 @default.
• W4297106246 cites W2309067861 @default.
• W4297106246 cites W2345415641 @default.
• W4297106246 cites W2407801906 @default.
• W4297106246 cites W2516619560 @default.
• W4297106246 cites W2547310148 @default.
• W4297106246 cites W2560367415 @default.
• W4297106246 cites W2625416742 @default.
• W4297106246 cites W2761720249 @default.
• W4297106246 cites W2803157002 @default.
• W4297106246 cites W2804930677 @default.
• W4297106246 cites W2811483470 @default.
• W4297106246 cites W2883459235 @default.
• W4297106246 cites W2885283829 @default.
• W4297106246 cites W2901515210 @default.
• W4297106246 cites W2911745810 @default.
• W4297106246 cites W2947020562 @default.
• W4297106246 cites W2969263349 @default.
• W4297106246 cites W2982216374 @default.
• W4297106246 cites W2998369814 @default.
• W4297106246 cites W3011214943 @default.
• W4297106246 cites W3028523516 @default.
• W4297106246 cites W3030448313 @default.
• W4297106246 cites W3042625264 @default.
• W4297106246 cites W3080945733 @default.
• W4297106246 cites W3081630303 @default.
• W4297106246 cites W3094622670 @default.
• W4297106246 cites W3101436145 @default.
• W4297106246 cites W3111189917 @default.
• W4297106246 cites W3180636127 @default.
• W4297106246 cites W4220798004 @default.
• W4297106246 doi "https://doi.org/10.1155/2022/3659714" @default.
• W4297106246 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/36199799" @default.
• W4297106246 hasPublicationYear "2022" @default.
• W4297106246 type Work @default.
• W4297106246 citedByCount "3" @default.
• W4297106246 countsByYear W42971062462023 @default.
• W4297106246 crossrefType "journal-article" @default.
• W4297106246 hasAuthorship W4297106246A5002578550 @default.
• W4297106246 hasAuthorship W4297106246A5031810848 @default.
• W4297106246 hasAuthorship W4297106246A5031965105 @default.
• W4297106246 hasAuthorship W4297106246A5045335829 @default.
• W4297106246 hasAuthorship W4297106246A5049270203 @default.
• W4297106246 hasAuthorship W4297106246A5054493580 @default.
• W4297106246 hasAuthorship W4297106246A5063457276 @default.
• W4297106246 hasAuthorship W4297106246A5065506624 @default.
• W4297106246 hasAuthorship W4297106246A5073022247 @default.
• W4297106246 hasAuthorship W4297106246A5075098016 @default.
• W4297106246 hasAuthorship W4297106246A5075689150 @default.
• W4297106246 hasBestOaLocation W42971062461 @default.
• W4297106246 hasConcept C104317684 @default.
• W4297106246 hasConcept C121608353 @default.
• W4297106246 hasConcept C126322002 @default.
• W4297106246 hasConcept C143998085 @default.
• W4297106246 hasConcept C203014093 @default.
• W4297106246 hasConcept C204232928 @default.
• W4297106246 hasConcept C2776415932 @default.
• W4297106246 hasConcept C2777701055 @default.
• W4297106246 hasConcept C2780110267 @default.
• W4297106246 hasConcept C2780851360 @default.
• W4297106246 hasConcept C2781053074 @default.
• W4297106246 hasConcept C502942594 @default.
• W4297106246 hasConcept C530470458 @default.
• W4297106246 hasConcept C55493867 @default.
• W4297106246 hasConcept C71924100 @default.
• W4297106246 hasConcept C86803240 @default.

• next