Matches in SemOpenAlex for { <https://semopenalex.org/work/W4297142267> ?p ?o ?g. }
- W4297142267 endingPage "e008215" @default.
- W4297142267 startingPage "e008215" @default.
- W4297142267 abstract "Introduction As new vaccines are developed more vaccine coadministrations vaccines are being offered to make delivery more practical for health systems and patients. We compared the safety of coadministered vaccines with separate vaccination for 20 coadministrations by considering nine types of adverse events following immunisation (AEFI). Methods Real-life immunisation and adverse event data for this observational cohort study were extracted from the Oxford-Royal College of General Practitioners Research and Surveillance Centre for children registered in the database between 2008 and 2018. We applied the self-controlled case series method to calculate relative incidence ratios (RIR) for AEFI. These RIRs compare the RI of AEFI following coadministration with the RI following separate administration of the same vaccines. Results We assessed 3 518 047 adverse events and included 5 993 290 vaccine doses given to 958 591 children. 17% of AEFI occurred less and 11% more frequently following coadministration than would have been expected based on the RIs following separate vaccinations, while there was no significant difference for 72% of AEFI. We found amplifying interaction effects for AEFI after five coadministrations comprising three vaccines: for fever (RIR 1.93 (95% CI 1.63 to 2.29)), rash (RIR 1.49 (95% CI 1.29 to 1.74)), gastrointestinal events (RIR 1.31 (95% CI 1.14 to 1.49)) and respiratory events (RIR 1.27 (1.17–1.38)) following DTaP/IPV/Hib+MenC+ PCV; gastrointestinal events (RIR 1.65 (95% CI 1.35 to 2.02)) following DTaP/IPV/Hib+MenC+ RV; fever (RIR 1.44 (95% CI 1.09 to 1.90)) and respiratory events (RIR 1.40 (95% CI 1.25 to 1.57)) following DTaP/IPV/Hib+PCV+ RV; gastrointestinal (RIR 1.48 (95% CI 1.20 to 1.82)) and respiratory events (RIR 1.43 (95% CI 1.26 to 1.63)) following MMR+Hib/MenC+PCV; gastrointestinal events (RIR 1.68 (95% CI 1.07 to 2.64)) and general symptoms (RIR 11.83 (95% CI 1.28 to 109.01)) following MMR+MenC+PCV. Coadministration of MMR+PCV led to more fever (RIR 1.91 (95% CI 1.83 to 1.99)), neurological events (RIR 2.04 (95% CI 1.67 to 2.49)) and rash (RIR 1.06 (95% CI 1.01 to 1.11)) compared with separate administration, DTaP/IPV/Hib+MMR to more musculoskeletal events (RIR 3.56 (95% CI 1.21 to 10.50)) and MMR+MenC to more fever (RIR 1.58 (95% CI 1.37 to 1.82)). There was no indication that unscheduled coadministrations are less safe than scheduled coadministrations. Conclusion Real-life RIRs of AEFI justify coadministering routine childhood vaccines according to the immunisation schedule. Further research into the severity of AEFI following coadministration is required for a complete understanding of the burden of these AEFI." @default.
- W4297142267 created "2022-09-27" @default.
- W4297142267 creator A5028700984 @default.
- W4297142267 creator A5040073469 @default.
- W4297142267 creator A5040160819 @default.
- W4297142267 creator A5065866497 @default.
- W4297142267 creator A5070885678 @default.
- W4297142267 creator A5085846822 @default.
- W4297142267 date "2022-09-01" @default.
- W4297142267 modified "2023-10-18" @default.
- W4297142267 title "Safety of routine childhood vaccine coadministration versus separate vaccination" @default.
- W4297142267 cites W109743369 @default.
- W4297142267 cites W1149054112 @default.
- W4297142267 cites W1788070085 @default.
- W4297142267 cites W1824674193 @default.
- W4297142267 cites W1969303209 @default.
- W4297142267 cites W1973595387 @default.
- W4297142267 cites W1999762730 @default.
- W4297142267 cites W1999849032 @default.
- W4297142267 cites W2023060733 @default.
- W4297142267 cites W2029641721 @default.
- W4297142267 cites W2032800808 @default.
- W4297142267 cites W2037834357 @default.
- W4297142267 cites W2058178384 @default.
- W4297142267 cites W2058371026 @default.
- W4297142267 cites W2058837954 @default.
- W4297142267 cites W2066046707 @default.
- W4297142267 cites W2092975949 @default.
- W4297142267 cites W2113049111 @default.
- W4297142267 cites W2119631017 @default.
- W4297142267 cites W2119906643 @default.
- W4297142267 cites W2121392872 @default.
- W4297142267 cites W2164907899 @default.
- W4297142267 cites W2185957587 @default.
- W4297142267 cites W2342254682 @default.
- W4297142267 cites W2385209049 @default.
- W4297142267 cites W2418097728 @default.
- W4297142267 cites W2462979556 @default.
- W4297142267 cites W2522161560 @default.
- W4297142267 cites W2551638189 @default.
- W4297142267 cites W2583619707 @default.
- W4297142267 cites W2620649449 @default.
- W4297142267 cites W2742031405 @default.
- W4297142267 cites W2783550374 @default.
- W4297142267 cites W2832414231 @default.
- W4297142267 cites W2901022943 @default.
- W4297142267 cites W2998528102 @default.
- W4297142267 cites W3007585631 @default.
- W4297142267 cites W3027590621 @default.
- W4297142267 cites W3029524692 @default.
- W4297142267 cites W3199770173 @default.
- W4297142267 cites W3209765450 @default.
- W4297142267 cites W4249695431 @default.
- W4297142267 cites W4294316040 @default.
- W4297142267 cites W68564277 @default.
- W4297142267 doi "https://doi.org/10.1136/bmjgh-2021-008215" @default.
- W4297142267 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/36162867" @default.
- W4297142267 hasPublicationYear "2022" @default.
- W4297142267 type Work @default.
- W4297142267 citedByCount "1" @default.
- W4297142267 countsByYear W42971422672023 @default.
- W4297142267 crossrefType "journal-article" @default.
- W4297142267 hasAuthorship W4297142267A5028700984 @default.
- W4297142267 hasAuthorship W4297142267A5040073469 @default.
- W4297142267 hasAuthorship W4297142267A5040160819 @default.
- W4297142267 hasAuthorship W4297142267A5065866497 @default.
- W4297142267 hasAuthorship W4297142267A5070885678 @default.
- W4297142267 hasAuthorship W4297142267A5085846822 @default.
- W4297142267 hasBestOaLocation W42971422671 @default.
- W4297142267 hasConcept C120665830 @default.
- W4297142267 hasConcept C121332964 @default.
- W4297142267 hasConcept C126322002 @default.
- W4297142267 hasConcept C159654299 @default.
- W4297142267 hasConcept C187212893 @default.
- W4297142267 hasConcept C197934379 @default.
- W4297142267 hasConcept C203014093 @default.
- W4297142267 hasConcept C22070199 @default.
- W4297142267 hasConcept C23131810 @default.
- W4297142267 hasConcept C2778570526 @default.
- W4297142267 hasConcept C2780801004 @default.
- W4297142267 hasConcept C3019706980 @default.
- W4297142267 hasConcept C61511704 @default.
- W4297142267 hasConcept C71924100 @default.
- W4297142267 hasConcept C72563966 @default.
- W4297142267 hasConceptScore W4297142267C120665830 @default.
- W4297142267 hasConceptScore W4297142267C121332964 @default.
- W4297142267 hasConceptScore W4297142267C126322002 @default.
- W4297142267 hasConceptScore W4297142267C159654299 @default.
- W4297142267 hasConceptScore W4297142267C187212893 @default.
- W4297142267 hasConceptScore W4297142267C197934379 @default.
- W4297142267 hasConceptScore W4297142267C203014093 @default.
- W4297142267 hasConceptScore W4297142267C22070199 @default.
- W4297142267 hasConceptScore W4297142267C23131810 @default.
- W4297142267 hasConceptScore W4297142267C2778570526 @default.
- W4297142267 hasConceptScore W4297142267C2780801004 @default.
- W4297142267 hasConceptScore W4297142267C3019706980 @default.
- W4297142267 hasConceptScore W4297142267C61511704 @default.
- W4297142267 hasConceptScore W4297142267C71924100 @default.