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- W4297150632 abstract "The aberrant expression of cancer-related genes can lead to colorectal cancer (CRC) carcinogenesis, and DNA methylation is one of the causes of abnormal expression. Although many studies have been conducted to reveal how DNA methylation affects transcription regulation, the ways in which it modulates gene expression and the regions that significantly affect DNA methylation-mediated gene regulation remain unclear. In this study, we investigated how DNA methylation in specific genomic areas can influence gene expression. Several regression models were constructed for gene expression prediction based on DNA methylation. Among these models, ElasticNet, which had the best performance, was chosen for further analysis. DNA methylation near transcription start sites (TSS), especially from 2 kb upstream to 7 kb downstream of TSS, had an essential regulatory role in gene expression. Moreover, methylation-affected and survival-associated genes were compiled and found to be mainly enriched in immune-related pathways. This study investigated genomic regions in which methylation changes can affect gene expression. In addition, this study proposed that aberrantly expressed genes due to DNA methylation can lead to CRC pathogenesis by the immune system." @default.
- W4297150632 created "2022-09-27" @default.
- W4297150632 creator A5012207088 @default.
- W4297150632 creator A5025476417 @default.
- W4297150632 date "2022-09-23" @default.
- W4297150632 modified "2023-10-11" @default.
- W4297150632 title "Genomic Effect of DNA Methylation on Gene Expression in Colorectal Cancer" @default.
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- W4297150632 cites W2013045624 @default.
- W4297150632 cites W2014555332 @default.
- W4297150632 cites W2015611021 @default.
- W4297150632 cites W2016210396 @default.
- W4297150632 cites W2017502278 @default.
- W4297150632 cites W2024819383 @default.
- W4297150632 cites W2032347891 @default.
- W4297150632 cites W2032999587 @default.
- W4297150632 cites W2041263849 @default.
- W4297150632 cites W2043398720 @default.
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- W4297150632 cites W2050395200 @default.
- W4297150632 cites W2054047930 @default.
- W4297150632 cites W2074159076 @default.
- W4297150632 cites W2090022532 @default.
- W4297150632 cites W2096745936 @default.
- W4297150632 cites W2097360283 @default.
- W4297150632 cites W2098545729 @default.
- W4297150632 cites W2109857232 @default.
- W4297150632 cites W2117692326 @default.
- W4297150632 cites W2122683221 @default.
- W4297150632 cites W2127552572 @default.
- W4297150632 cites W2129541946 @default.
- W4297150632 cites W2133093811 @default.
- W4297150632 cites W2134526812 @default.
- W4297150632 cites W2147003974 @default.
- W4297150632 cites W2148521032 @default.
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- W4297150632 cites W2169456326 @default.
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- W4297150632 cites W2343740944 @default.
- W4297150632 cites W2461427403 @default.
- W4297150632 cites W2565278636 @default.
- W4297150632 cites W2591052066 @default.
- W4297150632 cites W2613281257 @default.
- W4297150632 cites W2750576060 @default.
- W4297150632 cites W2802211415 @default.
- W4297150632 cites W2803068508 @default.
- W4297150632 cites W2810143528 @default.
- W4297150632 cites W2897640568 @default.
- W4297150632 cites W2897914417 @default.
- W4297150632 cites W2899029134 @default.
- W4297150632 cites W2942196124 @default.
- W4297150632 cites W2945537500 @default.
- W4297150632 cites W2962931338 @default.
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- W4297150632 cites W3006983403 @default.
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- W4297150632 cites W3009087937 @default.
- W4297150632 cites W3025322808 @default.
- W4297150632 cites W3042884090 @default.
- W4297150632 cites W3088384582 @default.
- W4297150632 cites W3102459492 @default.
- W4297150632 cites W3120268972 @default.
- W4297150632 cites W3128646645 @default.
- W4297150632 cites W3129004957 @default.
- W4297150632 cites W3135141542 @default.
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- W4297150632 doi "https://doi.org/10.3390/biology11101388" @default.
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- W4297150632 hasPublicationYear "2022" @default.
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