Matches in SemOpenAlex for { <https://semopenalex.org/work/W4297154039> ?p ?o ?g. }
- W4297154039 abstract "Hepatocellular carcinoma (HCC) is one of the most common primary cancers with limited therapeutic options. Melatonin, a neuroendocrine hormone produced primarily by the pineal gland, demonstrates an anti-cancer effect on a myriad of cancers including HCC. However, whether melatonin could suppress tumor growth through regulating RNA alternative splicing remains largely unknown. Here we demonstrated that melatonin could inhibit the growth of HCC. Mechanistically, melatonin induced transcriptional alterations of genes, which are involved in DNA replication, DNA metabolic process, DNA repair, response to wounding, steroid metabolic process, and extracellular matrix functions. Importantly, melatonin controlled numerous cancer-related RNA alternative splicing events, regulating mitotic cell cycle, microtubule-based process, kinase activity, DNA metabolic process, GTPase regulator activity functions. The regulatory effect of melatonin on alternative splicing is partially mediated by melatonin receptor MT1. Specifically, melatonin regulates the splicing of IKBKG (NEMO), an essential modulator of NF-κB. In brief, melatonin increased the production of the long isoform of NEMO-L with exon 5 inclusion, thereby inhibiting the growth of HepG2 cells. Collectively, our study provides a novel mechanism of melatonin in regulating RNA alternative splicing, and offers a new perspective for melatonin in the inhibition of cancer progression." @default.
- W4297154039 created "2022-09-27" @default.
- W4297154039 creator A5030488812 @default.
- W4297154039 creator A5037742843 @default.
- W4297154039 creator A5049547086 @default.
- W4297154039 creator A5053985637 @default.
- W4297154039 creator A5055875257 @default.
- W4297154039 creator A5058180593 @default.
- W4297154039 creator A5072921786 @default.
- W4297154039 creator A5073615382 @default.
- W4297154039 creator A5074396098 @default.
- W4297154039 creator A5080456227 @default.
- W4297154039 creator A5082223185 @default.
- W4297154039 date "2022-09-26" @default.
- W4297154039 modified "2023-10-12" @default.
- W4297154039 title "Melatonin inhibits HCC progression through regulating the alternative splicing of NEMO" @default.
- W4297154039 cites W1604242292 @default.
- W4297154039 cites W1987497009 @default.
- W4297154039 cites W2047791731 @default.
- W4297154039 cites W2054077890 @default.
- W4297154039 cites W2060696024 @default.
- W4297154039 cites W2068037459 @default.
- W4297154039 cites W2073196430 @default.
- W4297154039 cites W2094488327 @default.
- W4297154039 cites W2101025849 @default.
- W4297154039 cites W2144235090 @default.
- W4297154039 cites W2146295783 @default.
- W4297154039 cites W2151132444 @default.
- W4297154039 cites W2159437534 @default.
- W4297154039 cites W2407351686 @default.
- W4297154039 cites W2491334151 @default.
- W4297154039 cites W2502104717 @default.
- W4297154039 cites W2575397619 @default.
- W4297154039 cites W2611397450 @default.
- W4297154039 cites W2618859545 @default.
- W4297154039 cites W2790484942 @default.
- W4297154039 cites W2910331325 @default.
- W4297154039 cites W2911234092 @default.
- W4297154039 cites W2937283039 @default.
- W4297154039 cites W2943327026 @default.
- W4297154039 cites W2969802526 @default.
- W4297154039 cites W2993375404 @default.
- W4297154039 cites W3016273280 @default.
- W4297154039 cites W3025509561 @default.
- W4297154039 cites W3035408975 @default.
- W4297154039 cites W3048102544 @default.
- W4297154039 cites W3091597462 @default.
- W4297154039 cites W3096529293 @default.
- W4297154039 cites W3119084804 @default.
- W4297154039 cites W3128646645 @default.
- W4297154039 cites W3155979978 @default.
- W4297154039 cites W3157579748 @default.
- W4297154039 cites W3175661403 @default.
- W4297154039 cites W4211183069 @default.
- W4297154039 doi "https://doi.org/10.3389/fphar.2022.1007006" @default.
- W4297154039 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/36225557" @default.
- W4297154039 hasPublicationYear "2022" @default.
- W4297154039 type Work @default.
- W4297154039 citedByCount "1" @default.
- W4297154039 countsByYear W42971540392023 @default.
- W4297154039 crossrefType "journal-article" @default.
- W4297154039 hasAuthorship W4297154039A5030488812 @default.
- W4297154039 hasAuthorship W4297154039A5037742843 @default.
- W4297154039 hasAuthorship W4297154039A5049547086 @default.
- W4297154039 hasAuthorship W4297154039A5053985637 @default.
- W4297154039 hasAuthorship W4297154039A5055875257 @default.
- W4297154039 hasAuthorship W4297154039A5058180593 @default.
- W4297154039 hasAuthorship W4297154039A5072921786 @default.
- W4297154039 hasAuthorship W4297154039A5073615382 @default.
- W4297154039 hasAuthorship W4297154039A5074396098 @default.
- W4297154039 hasAuthorship W4297154039A5080456227 @default.
- W4297154039 hasAuthorship W4297154039A5082223185 @default.
- W4297154039 hasBestOaLocation W42971540391 @default.
- W4297154039 hasConcept C104317684 @default.
- W4297154039 hasConcept C134018914 @default.
- W4297154039 hasConcept C194583182 @default.
- W4297154039 hasConcept C2778182776 @default.
- W4297154039 hasConcept C36823959 @default.
- W4297154039 hasConcept C502942594 @default.
- W4297154039 hasConcept C54355233 @default.
- W4297154039 hasConcept C54458228 @default.
- W4297154039 hasConcept C67705224 @default.
- W4297154039 hasConcept C86803240 @default.
- W4297154039 hasConcept C95444343 @default.
- W4297154039 hasConceptScore W4297154039C104317684 @default.
- W4297154039 hasConceptScore W4297154039C134018914 @default.
- W4297154039 hasConceptScore W4297154039C194583182 @default.
- W4297154039 hasConceptScore W4297154039C2778182776 @default.
- W4297154039 hasConceptScore W4297154039C36823959 @default.
- W4297154039 hasConceptScore W4297154039C502942594 @default.
- W4297154039 hasConceptScore W4297154039C54355233 @default.
- W4297154039 hasConceptScore W4297154039C54458228 @default.
- W4297154039 hasConceptScore W4297154039C67705224 @default.
- W4297154039 hasConceptScore W4297154039C86803240 @default.
- W4297154039 hasConceptScore W4297154039C95444343 @default.
- W4297154039 hasLocation W42971540391 @default.
- W4297154039 hasLocation W42971540392 @default.
- W4297154039 hasLocation W42971540393 @default.
- W4297154039 hasLocation W42971540394 @default.
- W4297154039 hasOpenAccess W4297154039 @default.