Matches in SemOpenAlex for { <https://semopenalex.org/work/W4297156985> ?p ?o ?g. }
Showing items 1 to 62 of
62
with 100 items per page.
- W4297156985 endingPage "388" @default.
- W4297156985 startingPage "375" @default.
- W4297156985 abstract "Voltage-dependent Na+ channels have been recognized for many years as targets for local anesthetic and antiarrhythmic drugs. In the past ten years, Na+ channels have increasingly been recognized as a target for anticonvulsant drugs (e.g. phenytoin, carbamazepine, lamotrigine). This same class of drugs has been used to treat neuropathic pain such as from trigeminal neuralgia, diabetic neuropathy or other nerve damage. More recently, it has become clear from results in vitro and with animal models that Na+ channel modulators similar to anticonvulsants have neuroprotective actions against ischemia, trauma and neurodegenerative diseases. This bri f review covers recent advances in the molecular biology of mammalian Na+ channels and the evidence that Na+ channel blockade with both conventional drugs and recently synthesized compounds may be useful for treatment of a variety of CNS diseases." @default.
- W4297156985 created "2022-09-27" @default.
- W4297156985 creator A5017744691 @default.
- W4297156985 date "1996-08-01" @default.
- W4297156985 modified "2023-10-16" @default.
- W4297156985 title "Voltage-gated Na+ Channels as Targets for Anticonvulsant, Analgesic and Neuroprotective Drugs" @default.
- W4297156985 doi "https://doi.org/10.2174/1381612802666220925203150" @default.
- W4297156985 hasPublicationYear "1996" @default.
- W4297156985 type Work @default.
- W4297156985 citedByCount "8" @default.
- W4297156985 countsByYear W42971569852014 @default.
- W4297156985 countsByYear W42971569852021 @default.
- W4297156985 crossrefType "journal-article" @default.
- W4297156985 hasAuthorship W4297156985A5017744691 @default.
- W4297156985 hasConcept C118552586 @default.
- W4297156985 hasConcept C169760540 @default.
- W4297156985 hasConcept C25498285 @default.
- W4297156985 hasConcept C2775858608 @default.
- W4297156985 hasConcept C2777107010 @default.
- W4297156985 hasConcept C2778186239 @default.
- W4297156985 hasConcept C2778337148 @default.
- W4297156985 hasConcept C2778802184 @default.
- W4297156985 hasConcept C2779253243 @default.
- W4297156985 hasConcept C2780820201 @default.
- W4297156985 hasConcept C42219234 @default.
- W4297156985 hasConcept C71924100 @default.
- W4297156985 hasConcept C86803240 @default.
- W4297156985 hasConcept C98274493 @default.
- W4297156985 hasConceptScore W4297156985C118552586 @default.
- W4297156985 hasConceptScore W4297156985C169760540 @default.
- W4297156985 hasConceptScore W4297156985C25498285 @default.
- W4297156985 hasConceptScore W4297156985C2775858608 @default.
- W4297156985 hasConceptScore W4297156985C2777107010 @default.
- W4297156985 hasConceptScore W4297156985C2778186239 @default.
- W4297156985 hasConceptScore W4297156985C2778337148 @default.
- W4297156985 hasConceptScore W4297156985C2778802184 @default.
- W4297156985 hasConceptScore W4297156985C2779253243 @default.
- W4297156985 hasConceptScore W4297156985C2780820201 @default.
- W4297156985 hasConceptScore W4297156985C42219234 @default.
- W4297156985 hasConceptScore W4297156985C71924100 @default.
- W4297156985 hasConceptScore W4297156985C86803240 @default.
- W4297156985 hasConceptScore W4297156985C98274493 @default.
- W4297156985 hasIssue "4" @default.
- W4297156985 hasLocation W42971569851 @default.
- W4297156985 hasOpenAccess W4297156985 @default.
- W4297156985 hasPrimaryLocation W42971569851 @default.
- W4297156985 hasRelatedWork W1954411904 @default.
- W4297156985 hasRelatedWork W1994926226 @default.
- W4297156985 hasRelatedWork W2020426939 @default.
- W4297156985 hasRelatedWork W2080867598 @default.
- W4297156985 hasRelatedWork W2089126407 @default.
- W4297156985 hasRelatedWork W2089746798 @default.
- W4297156985 hasRelatedWork W2091102159 @default.
- W4297156985 hasRelatedWork W2098549463 @default.
- W4297156985 hasRelatedWork W2153335219 @default.
- W4297156985 hasRelatedWork W2268771989 @default.
- W4297156985 hasVolume "2" @default.
- W4297156985 isParatext "false" @default.
- W4297156985 isRetracted "false" @default.
- W4297156985 workType "article" @default.