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- W4297162325 abstract "THE effect of specific irreversible inhibitors of complexes I, III, IV and V of the mitochondrial respiratory chain, (rotenone, myxothiazol, cyanide and oligomycin, respectively) on mitochondrial N-acetylaspartate production, and its relationship to oxidative phosphorylation (ATP production and oxygen consumption) were investigated in isolated rat brain mitochondria. Mitochondrial N- acetylaspartate production, ATP production and oxygen consumption were all significantly decreased in the presence of each of the inhibitors used compared with control incubations, and correlated positively with each other. It is postulated that decreased N-acetylaspartate levels seen in disease states by 1H NMR spectroscopy in vivo may reflect primarily an impaired mitochondrial energy production rather than neuronal cell loss." @default.
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- W4297162325 date "1996-05-01" @default.
- W4297162325 modified "2023-10-09" @default.
- W4297162325 title "Inhibition of N-acetylaspartate production" @default.
- W4297162325 doi "https://doi.org/10.1097/00001756-199605310-00014" @default.
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