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- W4297173816 abstract "Abstract: Objectives: To explore the effects of allicin on the expression of mitochondrial autophagyrelated proteins in liver tissues of hepatic fibrosis (HF) rats. Materials and Methods: 45 SD rats were randomly divided into Normal, Model, Low, Middle and High groups. The HF rat model was replicated intraperitoneal injection of carbon tetrachloride and ethanol gavage for 4 weeks. Detection of alanine aminotransferase (ALT) and aspartate aminotransferase (AST) in rat serum; HE and Masson staining to observe pathological changes; Evaluating LC 3B protein expression by Immunofluorescence; Western Blotting and qRT-PCR methods were used to detect PINK1, Parkin, Beclin 1, and LC3 gene and protein expression levels in rat liver tissues. Results: Compared with the Normal group, the degree of HF in the model group was obvious, the volume fraction of collagen increased significantly (p<0.001), the LC 3B protein expression significantly upregulation (p<0.001), and the rat serum ALT and AST increased significantly (p<0.001, respectively). Up-regulation of PINK1, Parkin, Beclin 1, and LC 3B mRNA and protein expression and LC 3II/LC 3I ratio in liver tissues (p<0.001, respectively); Compared with the model group, Allicin treated groups had reduced HF degree, collagen volume fraction decreased significantly (p<0.05, respectively), LC 3B protein was significantly reduced (p<0.05, respectively), and liver tissue PINK1, Parkin, Beclin 1, and LC3B mRNA and protein expressions, and LC 3II/LC 3I ratio were down-regulated (p<0.05, respectively). Conclusion:Allicin could improve hepatic fibrosis. The mechanism might be related to down-regulating the expression of PINK1, Parkin, Beclin 1, and LC 3 gene and proteins and interfering with the level of mitochondrial autophagy Keywords: Allicin, HF, PINK1, Parkin, Autophagy." @default.
- W4297173816 created "2022-09-27" @default.
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- W4297173816 date "2022-09-23" @default.
- W4297173816 modified "2023-09-25" @default.
- W4297173816 title "Mechanism of Allicin for Improvement of Hepatic Fibrosis by Regulating Autophagy" @default.
- W4297173816 doi "https://doi.org/10.5530/ijper.56.4.191" @default.
- W4297173816 hasPublicationYear "2022" @default.
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