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- W4297183404 abstract "In ‘Fear conditioning as a pathogenic mechanism in the postural tachycardia syndrome’,1 the investigators document a number of associations. They report that patients with postural tachycardia syndrome, or POTS, scored higher on anxiety and ‘somatic vigilance’—that is, paying attention to bodily sensations—than controls. They report that POTS patients, compared to controls, had a ‘more pronounced anticipatory tachycardia’ when alerted to a coming tilt-table test that would position them upright. They report that, compared to controls, POTS patients positioned upright during the tilt-table test had faster heart rate, higher plasma catecholamine levels, lower end-tidal CO2 and reduced middle cerebral artery blood flow velocity. The investigators explain the findings by positing that POTS patients have a ‘classic Pavlovian fear conditioning’ response developed after a prior episode of having unpleasant symptoms upon standing. They describe the anticipatory tachycardia as ‘a physiologic indicator of fear conditioning to orthostasis’—an assertion presumably designed to bolster the argument that negative past experiences trigger current POTS symptoms. At the end of the limitations section, the investigators acknowledge, as if in passing, that they ‘do not know’ if their findings ‘are a cause or a consequence of the syndrome.’ Despite this significant and obvious knowledge gap, they nonetheless maintain that the results provide robust support for their characterization of POTS as a ‘functional psychogenic disorder.’" @default.
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- W4297183404 date "2022-09-24" @default.
- W4297183404 modified "2023-10-03" @default.
- W4297183404 title "‘Psychogenic’ POTS: the NYU team misinterprets association as causation" @default.
- W4297183404 cites W4284972785 @default.
- W4297183404 doi "https://doi.org/10.1093/brain/awac348" @default.
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