FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4297196225> ?p ?o ?g. }

• W4297196225 abstract "The development and clinical implementation of evidence-based precision medicine strategies has become a realistic possibility, primarily due to the rapid accumulation of large-scale genomics and pharmacological data from diverse model systems: patients, cell lines and drug perturbation studies. We introduce a novel Bayesian modeling framework called the individualized theRapeutic index (iRx) model to integrate high-throughput pharmacogenomic data across model systems. Our iRx model achieves three main goals: first, it exploits the conserved biology between patients and cell lines to calibrate therapeutic response of drugs in patients; second, it finds optimal cell line avatars as proxies for patient(s); and finally, it identifies key genomic drivers explaining cell line-patient similarities. This is achieved through a semi-supervised learning approach that conflates (unsupervised) sparse latent factor models with (supervised) penalized regression techniques. We propose a unified and tractable Bayesian model for estimation, and inference is conducted via efficient posterior sampling schemes. We illustrate and validate our approach using two existing clinical trial data sets in multiple myeloma and breast cancer studies. We show that our iRx model improves prediction accuracy compared to naive alternative approaches, and it consistently outperforms existing methods in literature in both multiple simulation scenarios as well as real clinical examples." @default.
• W4297196225 created "2022-09-27" @default.
• W4297196225 creator A5024470416 @default.
• W4297196225 creator A5025337058 @default.
• W4297196225 creator A5039812679 @default.
• W4297196225 creator A5042591595 @default.
• W4297196225 date "2022-12-01" @default.
• W4297196225 modified "2023-09-27" @default.
• W4297196225 title "A Bayesian precision medicine framework for calibrating individualized therapeutic indices in cancer" @default.
• W4297196225 cites W1479807131 @default.
• W4297196225 cites W1989949458 @default.
• W4297196225 cites W1995450389 @default.
• W4297196225 cites W1997338647 @default.
• W4297196225 cites W2018663224 @default.
• W4297196225 cites W2029721016 @default.
• W4297196225 cites W2067046795 @default.
• W4297196225 cites W2100603815 @default.
• W4297196225 cites W2107940314 @default.
• W4297196225 cites W2115460701 @default.
• W4297196225 cites W2122376507 @default.
• W4297196225 cites W2131083915 @default.
• W4297196225 cites W2132485651 @default.
• W4297196225 cites W2148534890 @default.
• W4297196225 cites W2162143298 @default.
• W4297196225 cites W2225934353 @default.
• W4297196225 cites W2341128841 @default.
• W4297196225 cites W2492689508 @default.
• W4297196225 cites W2565408756 @default.
• W4297196225 cites W2566656214 @default.
• W4297196225 cites W2739254074 @default.
• W4297196225 cites W2765136070 @default.
• W4297196225 cites W2776533520 @default.
• W4297196225 cites W2784057214 @default.
• W4297196225 cites W2807675497 @default.
• W4297196225 cites W2810324851 @default.
• W4297196225 cites W2963340261 @default.
• W4297196225 cites W2963601606 @default.
• W4297196225 cites W3021499551 @default.
• W4297196225 cites W3098705660 @default.
• W4297196225 cites W3122858766 @default.
• W4297196225 cites W3146265467 @default.
• W4297196225 cites W4234698323 @default.
• W4297196225 cites W4249731213 @default.
• W4297196225 doi "https://doi.org/10.1214/21-aoas1550" @default.
• W4297196225 hasPublicationYear "2022" @default.
• W4297196225 type Work @default.
• W4297196225 citedByCount "0" @default.
• W4297196225 crossrefType "journal-article" @default.
• W4297196225 hasAuthorship W4297196225A5024470416 @default.
• W4297196225 hasAuthorship W4297196225A5025337058 @default.
• W4297196225 hasAuthorship W4297196225A5039812679 @default.
• W4297196225 hasAuthorship W4297196225A5042591595 @default.
• W4297196225 hasBestOaLocation W42971962252 @default.
• W4297196225 hasConcept C105795698 @default.
• W4297196225 hasConcept C107673813 @default.
• W4297196225 hasConcept C119857082 @default.
• W4297196225 hasConcept C142724271 @default.
• W4297196225 hasConcept C154945302 @default.
• W4297196225 hasConcept C160234255 @default.
• W4297196225 hasConcept C163763905 @default.
• W4297196225 hasConcept C185429906 @default.
• W4297196225 hasConcept C2776214188 @default.
• W4297196225 hasConcept C32220436 @default.
• W4297196225 hasConcept C33923547 @default.
• W4297196225 hasConcept C41008148 @default.
• W4297196225 hasConcept C60644358 @default.
• W4297196225 hasConcept C71924100 @default.
• W4297196225 hasConcept C86803240 @default.
• W4297196225 hasConceptScore W4297196225C105795698 @default.
• W4297196225 hasConceptScore W4297196225C107673813 @default.
• W4297196225 hasConceptScore W4297196225C119857082 @default.
• W4297196225 hasConceptScore W4297196225C142724271 @default.
• W4297196225 hasConceptScore W4297196225C154945302 @default.
• W4297196225 hasConceptScore W4297196225C160234255 @default.
• W4297196225 hasConceptScore W4297196225C163763905 @default.
• W4297196225 hasConceptScore W4297196225C185429906 @default.
• W4297196225 hasConceptScore W4297196225C2776214188 @default.
• W4297196225 hasConceptScore W4297196225C32220436 @default.
• W4297196225 hasConceptScore W4297196225C33923547 @default.
• W4297196225 hasConceptScore W4297196225C41008148 @default.
• W4297196225 hasConceptScore W4297196225C60644358 @default.
• W4297196225 hasConceptScore W4297196225C71924100 @default.
• W4297196225 hasConceptScore W4297196225C86803240 @default.
• W4297196225 hasIssue "4" @default.
• W4297196225 hasLocation W42971962251 @default.
• W4297196225 hasLocation W42971962252 @default.
• W4297196225 hasOpenAccess W4297196225 @default.
• W4297196225 hasPrimaryLocation W42971962251 @default.
• W4297196225 hasRelatedWork W2104594922 @default.
• W4297196225 hasRelatedWork W2589314268 @default.
• W4297196225 hasRelatedWork W2753218748 @default.
• W4297196225 hasRelatedWork W2774409638 @default.
• W4297196225 hasRelatedWork W2789413038 @default.
• W4297196225 hasRelatedWork W2889562828 @default.
• W4297196225 hasRelatedWork W2952635455 @default.
• W4297196225 hasRelatedWork W2953280030 @default.
• W4297196225 hasRelatedWork W3002319139 @default.
• W4297196225 hasRelatedWork W4300815303 @default.
• W4297196225 hasVolume "16" @default.
• W4297196225 isParatext "false" @default.

• next