Matches in SemOpenAlex for { <https://semopenalex.org/work/W4297199930> ?p ?o ?g. }
- W4297199930 abstract "Outer segment phagocytosis (OSP) is a highly-regulated, biological process wherein photoreceptor outer segment (OS) tips are cyclically phagocytosed by the adjacent retinal pigment epithelium (RPE) cells. Often an overlooked retinal process, rhythmic OSP ensures the maintenance of healthy photoreceptors and vision. Daily, the photoreceptors renew OS at their base and the most distal, and likely oldest, OS tips, are phagocytosed by the RPE, preventing the accumulation of photo-oxidative compounds by breaking down phagocytosed OS tips and recycling useful components to the photoreceptors. Light changes often coincide with an escalation of OSP and within hours the phagosomes formed in each RPE cell are resolved. In the last two decades, individual molecular regulators were elucidated. Some of the molecular machinery used by RPE cells for OSP is highly similar to mechanisms used by other phagocytic cells for the clearance of apoptotic cells. Consequently, in the RPE, many molecular regulators of retinal phagocytosis have been elucidated. However, there is still a knowledge gap regarding the key regulators of physiological OSP in vivo between endogenous photoreceptors and the RPE. Understanding the regulation of OSP is of significant clinical interest as age-related macular degeneration (AMD) and inherited retinal diseases (IRD) are linked with altered OSP. Here, we review the in vivo timing of OSP peaks in selected species and focus on the reported in vivo environmental and molecular regulators of OSP." @default.
- W4297199930 created "2022-09-27" @default.
- W4297199930 creator A5010822718 @default.
- W4297199930 creator A5019859871 @default.
- W4297199930 creator A5021655948 @default.
- W4297199930 creator A5034070107 @default.
- W4297199930 creator A5052130969 @default.
- W4297199930 date "2022-09-27" @default.
- W4297199930 modified "2023-09-30" @default.
- W4297199930 title "Regulation of the rhythmic diversity of daily photoreceptor outer segment phagocytosis in vivo" @default.
- W4297199930 cites W118255430 @default.
- W4297199930 cites W138859237 @default.
- W4297199930 cites W142399797 @default.
- W4297199930 cites W1502919768 @default.
- W4297199930 cites W1546846595 @default.
- W4297199930 cites W155508430 @default.
- W4297199930 cites W1560487523 @default.
- W4297199930 cites W1570559507 @default.
- W4297199930 cites W1655179253 @default.
- W4297199930 cites W168681649 @default.
- W4297199930 cites W179520287 @default.
- W4297199930 cites W1963591622 @default.
- W4297199930 cites W1964877886 @default.
- W4297199930 cites W1965318586 @default.
- W4297199930 cites W1970528463 @default.
- W4297199930 cites W1975436727 @default.
- W4297199930 cites W1976263073 @default.
- W4297199930 cites W1987319020 @default.
- W4297199930 cites W1988214506 @default.
- W4297199930 cites W1989089629 @default.
- W4297199930 cites W1992788147 @default.
- W4297199930 cites W1993913137 @default.
- W4297199930 cites W1994833443 @default.
- W4297199930 cites W1995368435 @default.
- W4297199930 cites W2000797677 @default.
- W4297199930 cites W2003184463 @default.
- W4297199930 cites W2006116530 @default.
- W4297199930 cites W2007309150 @default.
- W4297199930 cites W2009266531 @default.
- W4297199930 cites W2009789841 @default.
- W4297199930 cites W2012117469 @default.
- W4297199930 cites W2014187478 @default.
- W4297199930 cites W2014852513 @default.
- W4297199930 cites W2021234912 @default.
- W4297199930 cites W2024224516 @default.
- W4297199930 cites W2028691987 @default.
- W4297199930 cites W2028999663 @default.
- W4297199930 cites W2033823572 @default.
- W4297199930 cites W2045857922 @default.
- W4297199930 cites W2048485183 @default.
- W4297199930 cites W2051747007 @default.
- W4297199930 cites W2052977563 @default.
- W4297199930 cites W2057666929 @default.
- W4297199930 cites W2062898847 @default.
- W4297199930 cites W2067299582 @default.
- W4297199930 cites W2073611192 @default.
- W4297199930 cites W2078320036 @default.
- W4297199930 cites W2081299478 @default.
- W4297199930 cites W2082211576 @default.
- W4297199930 cites W2083790180 @default.
- W4297199930 cites W2085603287 @default.
- W4297199930 cites W2086790354 @default.
- W4297199930 cites W2092763268 @default.
- W4297199930 cites W2095004571 @default.
- W4297199930 cites W2101909393 @default.
- W4297199930 cites W2103894947 @default.
- W4297199930 cites W2105465142 @default.
- W4297199930 cites W2105818167 @default.
- W4297199930 cites W2112214463 @default.
- W4297199930 cites W2128791527 @default.
- W4297199930 cites W2129723413 @default.
- W4297199930 cites W2131552046 @default.
- W4297199930 cites W2137331743 @default.
- W4297199930 cites W2145249666 @default.
- W4297199930 cites W2147481857 @default.
- W4297199930 cites W2148756146 @default.
- W4297199930 cites W2149042404 @default.
- W4297199930 cites W2150008097 @default.
- W4297199930 cites W2150473872 @default.
- W4297199930 cites W2153312133 @default.
- W4297199930 cites W2158339456 @default.
- W4297199930 cites W2160550697 @default.
- W4297199930 cites W2164597697 @default.
- W4297199930 cites W2167429009 @default.
- W4297199930 cites W2227187219 @default.
- W4297199930 cites W2255190151 @default.
- W4297199930 cites W2275271798 @default.
- W4297199930 cites W2291294034 @default.
- W4297199930 cites W2329085126 @default.
- W4297199930 cites W2333031609 @default.
- W4297199930 cites W2337798073 @default.
- W4297199930 cites W2469140818 @default.
- W4297199930 cites W2531412645 @default.
- W4297199930 cites W2575509790 @default.
- W4297199930 cites W2592850910 @default.
- W4297199930 cites W2595778161 @default.
- W4297199930 cites W2598018500 @default.
- W4297199930 cites W2604273370 @default.
- W4297199930 cites W2619869976 @default.
- W4297199930 cites W27009016 @default.