FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4297200000> ?p ?o ?g. }

• W4297200000 abstract "Abstract Recent research has already shown that circular RNAs (circRNAs) are functional in gene expression regulation and potentially related to diseases. Due to their stability, circRNAs can also be used as biomarkers for diagnosis. However, the function of most circRNAs remains unknown, and it is expensive and time-consuming to discover it through biological experiments. In this paper, we predict circRNA annotations from the knowledge of their interaction with miRNAs and subsequent miRNA–mRNA interactions. First, we construct an interaction network for a target circRNA and secondly spread the information from the network nodes with the known function to the root circRNA node. This idea itself is not new; our main contribution lies in proposing an efficient and exact deterministic procedure based on the principle of probability-generating functions to calculate the p -value of association test between a circRNA and an annotation term. We show that our publicly available algorithm is both more effective and efficient than the commonly used Monte-Carlo sampling approach that may suffer from difficult quantification of sampling convergence and subsequent sampling inefficiency. We experimentally demonstrate that the new approach is two orders of magnitude faster than the Monte-Carlo sampling, which makes summary annotation of large circRNA files feasible; this includes their reannotation after periodical interaction network updates, for example. We provide a summary annotation of a current circRNA database as one of our outputs. The proposed algorithm could be generalized towards other types of RNA in way that is straightforward." @default.
• W4297200000 created "2022-09-27" @default.
• W4297200000 creator A5037231538 @default.
• W4297200000 creator A5068736593 @default.
• W4297200000 creator A5080019407 @default.
• W4297200000 date "2022-09-27" @default.
• W4297200000 modified "2023-10-08" @default.
• W4297200000 title "circGPA: circRNA functional annotation based on probability-generating functions" @default.
• W4297200000 cites W1972898510 @default.
• W4297200000 cites W2010457001 @default.
• W4297200000 cites W2013223495 @default.
• W4297200000 cites W2053835153 @default.
• W4297200000 cites W2061554433 @default.
• W4297200000 cites W2066636486 @default.
• W4297200000 cites W2082099432 @default.
• W4297200000 cites W2083381199 @default.
• W4297200000 cites W2084344143 @default.
• W4297200000 cites W2097948046 @default.
• W4297200000 cites W2103209361 @default.
• W4297200000 cites W2112192177 @default.
• W4297200000 cites W2115662330 @default.
• W4297200000 cites W2128768066 @default.
• W4297200000 cites W2132940486 @default.
• W4297200000 cites W2134118500 @default.
• W4297200000 cites W2144086069 @default.
• W4297200000 cites W2155330008 @default.
• W4297200000 cites W2158135353 @default.
• W4297200000 cites W2159675211 @default.
• W4297200000 cites W2166637863 @default.
• W4297200000 cites W2167898988 @default.
• W4297200000 cites W2168316093 @default.
• W4297200000 cites W2210577735 @default.
• W4297200000 cites W2380800094 @default.
• W4297200000 cites W2617715606 @default.
• W4297200000 cites W2748354746 @default.
• W4297200000 cites W2755114649 @default.
• W4297200000 cites W2765950793 @default.
• W4297200000 cites W2768632638 @default.
• W4297200000 cites W2770983033 @default.
• W4297200000 cites W2791173369 @default.
• W4297200000 cites W2807602500 @default.
• W4297200000 cites W2884943532 @default.
• W4297200000 cites W2885229294 @default.
• W4297200000 cites W2889334297 @default.
• W4297200000 cites W2892630678 @default.
• W4297200000 cites W2898991725 @default.
• W4297200000 cites W2910111050 @default.
• W4297200000 cites W2951739649 @default.
• W4297200000 cites W2965393225 @default.
• W4297200000 cites W2969465064 @default.
• W4297200000 cites W2981316968 @default.
• W4297200000 cites W2999499437 @default.
• W4297200000 cites W3003617964 @default.
• W4297200000 cites W3004538479 @default.
• W4297200000 cites W3025741173 @default.
• W4297200000 cites W3027920886 @default.
• W4297200000 cites W3036265787 @default.
• W4297200000 cites W3047927730 @default.
• W4297200000 cites W3098523662 @default.
• W4297200000 cites W3101284010 @default.
• W4297200000 cites W3103443653 @default.
• W4297200000 cites W3110744205 @default.
• W4297200000 cites W3117084002 @default.
• W4297200000 cites W3140662957 @default.
• W4297200000 cites W3162005642 @default.
• W4297200000 cites W3179782236 @default.
• W4297200000 cites W3186206537 @default.
• W4297200000 cites W4200110750 @default.
• W4297200000 cites W4200140951 @default.
• W4297200000 cites W4213277551 @default.
• W4297200000 cites W4246271082 @default.
• W4297200000 cites W4285665422 @default.
• W4297200000 cites W4291302338 @default.
• W4297200000 cites W4291302339 @default.
• W4297200000 doi "https://doi.org/10.1186/s12859-022-04957-8" @default.
• W4297200000 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/36167495" @default.
• W4297200000 hasPublicationYear "2022" @default.
• W4297200000 type Work @default.
• W4297200000 citedByCount "1" @default.
• W4297200000 countsByYear W42972000002023 @default.
• W4297200000 crossrefType "journal-article" @default.
• W4297200000 hasAuthorship W4297200000A5037231538 @default.
• W4297200000 hasAuthorship W4297200000A5068736593 @default.
• W4297200000 hasAuthorship W4297200000A5080019407 @default.
• W4297200000 hasBestOaLocation W42972000001 @default.
• W4297200000 hasConcept C106131492 @default.
• W4297200000 hasConcept C124101348 @default.
• W4297200000 hasConcept C127413603 @default.
• W4297200000 hasConcept C14036430 @default.
• W4297200000 hasConcept C140779682 @default.
• W4297200000 hasConcept C154945302 @default.
• W4297200000 hasConcept C2776321320 @default.
• W4297200000 hasConcept C31972630 @default.
• W4297200000 hasConcept C41008148 @default.
• W4297200000 hasConcept C54355233 @default.
• W4297200000 hasConcept C62611344 @default.
• W4297200000 hasConcept C66938386 @default.
• W4297200000 hasConcept C86803240 @default.
• W4297200000 hasConceptScore W4297200000C106131492 @default.
• W4297200000 hasConceptScore W4297200000C124101348 @default.

• next