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- W4297201339 abstract "Protein nanoparticle scaffolds are increasingly used in next-generation vaccine designs, and several have established records of clinical safety and efficacy. Yet the rules for how immune responses specific to nanoparticle scaffolds affect the immunogenicity of displayed antigens have not been established. Here we define relationships between anti-scaffold and antigen-specific antibody responses elicited by protein nanoparticle immunogens. We report that dampening anti-scaffold responses by physical masking does not enhance antigen-specific antibody responses. In a series of immunogens that all use the same nanoparticle scaffold but display four different antigens, only HIV-1 envelope glycoprotein (Env) is subdominant to the scaffold. However, we also demonstrate that scaffold-specific antibody responses can competitively inhibit antigen-specific responses when the scaffold is provided in excess. Overall, our results suggest that anti-scaffold antibody responses are unlikely to suppress antigen-specific antibody responses for protein nanoparticle immunogens in which the antigen is immunodominant over the scaffold." @default.
- W4297201339 created "2022-09-27" @default.
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- W4297201339 date "2022-10-01" @default.
- W4297201339 modified "2023-10-18" @default.
- W4297201339 title "Antigen- and scaffold-specific antibody responses to protein nanoparticle immunogens" @default.
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- W4297201339 cites W1915453701 @default.
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- W4297201339 cites W1969689981 @default.
- W4297201339 cites W1984376606 @default.
- W4297201339 cites W2002844537 @default.
- W4297201339 cites W2007622060 @default.
- W4297201339 cites W2011136801 @default.
- W4297201339 cites W2017795981 @default.
- W4297201339 cites W2018888105 @default.
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- W4297201339 cites W2025212003 @default.
- W4297201339 cites W2027583787 @default.
- W4297201339 cites W2031152116 @default.
- W4297201339 cites W2046094044 @default.
- W4297201339 cites W2046182783 @default.
- W4297201339 cites W2049580315 @default.
- W4297201339 cites W2052937459 @default.
- W4297201339 cites W2058343458 @default.
- W4297201339 cites W2069454375 @default.
- W4297201339 cites W2069536579 @default.
- W4297201339 cites W2073047768 @default.
- W4297201339 cites W2084493621 @default.
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- W4297201339 cites W2093467319 @default.
- W4297201339 cites W2103832206 @default.
- W4297201339 cites W2104391453 @default.
- W4297201339 cites W2109541209 @default.
- W4297201339 cites W2124935744 @default.
- W4297201339 cites W2126114330 @default.
- W4297201339 cites W2128117338 @default.
- W4297201339 cites W2131859684 @default.
- W4297201339 cites W2132184418 @default.
- W4297201339 cites W2135151522 @default.
- W4297201339 cites W2135565823 @default.
- W4297201339 cites W2144155542 @default.
- W4297201339 cites W2155429177 @default.
- W4297201339 cites W2156754803 @default.
- W4297201339 cites W2158078729 @default.
- W4297201339 cites W2160180163 @default.
- W4297201339 cites W2161892929 @default.
- W4297201339 cites W2172319351 @default.
- W4297201339 cites W2200458744 @default.
- W4297201339 cites W2323929490 @default.
- W4297201339 cites W2491008760 @default.
- W4297201339 cites W2511617912 @default.
- W4297201339 cites W2518622185 @default.
- W4297201339 cites W2521741241 @default.
- W4297201339 cites W2605491919 @default.
- W4297201339 cites W2617717260 @default.
- W4297201339 cites W2622891750 @default.
- W4297201339 cites W2734356283 @default.
- W4297201339 cites W2746551126 @default.
- W4297201339 cites W2748260928 @default.
- W4297201339 cites W2750464792 @default.
- W4297201339 cites W2780290167 @default.
- W4297201339 cites W2782708334 @default.
- W4297201339 cites W2795740139 @default.
- W4297201339 cites W2887703287 @default.
- W4297201339 cites W2888011077 @default.
- W4297201339 cites W2896892676 @default.
- W4297201339 cites W2903361904 @default.
- W4297201339 cites W2903852362 @default.