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• W4297201468 abstract "The total synthesis of capuramycin (1), which is a promising anti-tubercular antibiotics, has been accomplished using Ferrier-type I reaction as a key step. This total synthesis is an alternative approach to the synthesis of capuramycin and its analogues. The 3'-O-demethyl analogue (2), which exhibits an equivalent antibacterial activity as capuramycin (1) against Mycobacterium smegmatis and Mycobacterium avium, is suggested to have potential as a lead structure of capuramycin analogues because 2 is more accessible from a synthetic view point." @default.
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• W4297201468 date "2022-11-01" @default.
• W4297201468 modified "2023-10-16" @default.
• W4297201468 title "Synthesis of capuramycin and its analogues via a Ferrier-type I reaction and their biological evaluation" @default.
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• W4297201468 doi "https://doi.org/10.1016/j.bmc.2022.117011" @default.
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