FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4297201515> ?p ?o ?g. }

• W4297201515 endingPage "101433" @default.
• W4297201515 startingPage "101433" @default.
• W4297201515 abstract "Heart failure (HF) with preserved ejection fraction (HFpEF) is a heterogeneous syndrome including several morphological phenotypes and varying pathophysiological mechanisms. The conventional classification of HF based on left ventricular ejection fraction (LVEF) has created an oversimplification in diagnostic criteria. Although LVEF is a standardized parameter easy to calculate and broadly applied in the large clinical trials, but it is erroneously considered an index of left ventricular (LV) systolic function. Indeed, it is affected by preload and afterload and it has limitations related to reproducibility, reduced sensitivity and scarce prognostic values especially when above 50%. Notably, additional diagnostic parameters have been recently proposed in order to improve diagnostic accuracy and to homogenize the different HFpEF populations. Unfortunately, these algorithms comprise sophisticated measurements that are difficult to apply in the daily clinical practice. Additionally, the scarce diffusion of these diagnostic criteria may have led to neutral or negative results in interventional phase 3 trials. We propose changes to the current HFpEF diagnostic approach mainly based on LVEF stratification measurement aiming towards a more inclusive model taking into consideration an integrative approach starting from the main diseases responsible for cardiac dysfunction through to cardiac structural and functional alterations. Accordingly, with recent universal HF definitions, a stepwise model could be helpful in recognizing patients with early vs. overt HFpEF by the appraisal of specific Doppler echocardiographic variables. Thus, we would encourage the application of new criteria in order to better identify the different phenotypes and to move towards more personalized medicine." @default.
• W4297201515 created "2022-09-27" @default.
• W4297201515 creator A5039153112 @default.
• W4297201515 creator A5045885776 @default.
• W4297201515 creator A5049273996 @default.
• W4297201515 creator A5050831729 @default.
• W4297201515 creator A5059582018 @default.
• W4297201515 creator A5074412810 @default.
• W4297201515 date "2023-01-01" @default.
• W4297201515 modified "2023-09-27" @default.
• W4297201515 title "The Conundrum of HFpEF Definition: Non-Invasive Assessment Uncertainties and Alternative Diagnostic Strategies" @default.
• W4297201515 cites W164205712 @default.
• W4297201515 cites W1688584553 @default.
• W4297201515 cites W1970771731 @default.
• W4297201515 cites W1972596003 @default.
• W4297201515 cites W1983102904 @default.
• W4297201515 cites W1984501899 @default.
• W4297201515 cites W1984623267 @default.
• W4297201515 cites W1990188040 @default.
• W4297201515 cites W2003399513 @default.
• W4297201515 cites W2005238372 @default.
• W4297201515 cites W2016173867 @default.
• W4297201515 cites W2021127613 @default.
• W4297201515 cites W2028139057 @default.
• W4297201515 cites W2034559923 @default.
• W4297201515 cites W2044630551 @default.
• W4297201515 cites W2048730845 @default.
• W4297201515 cites W2052900937 @default.
• W4297201515 cites W206069421 @default.
• W4297201515 cites W2067161021 @default.
• W4297201515 cites W2080501472 @default.
• W4297201515 cites W2081183027 @default.
• W4297201515 cites W2103313207 @default.
• W4297201515 cites W2112752965 @default.
• W4297201515 cites W2113829060 @default.
• W4297201515 cites W2116118059 @default.
• W4297201515 cites W2127039247 @default.
• W4297201515 cites W2127254785 @default.
• W4297201515 cites W2127749568 @default.
• W4297201515 cites W2137737196 @default.
• W4297201515 cites W2137784332 @default.
• W4297201515 cites W2148405482 @default.
• W4297201515 cites W2149841172 @default.
• W4297201515 cites W2151671899 @default.
• W4297201515 cites W2155104731 @default.
• W4297201515 cites W2161391746 @default.
• W4297201515 cites W2162217713 @default.
• W4297201515 cites W2181968881 @default.
• W4297201515 cites W2184584862 @default.
• W4297201515 cites W2328246101 @default.
• W4297201515 cites W2427094903 @default.
• W4297201515 cites W2519258210 @default.
• W4297201515 cites W2548447630 @default.
• W4297201515 cites W2554277983 @default.
• W4297201515 cites W2590369252 @default.
• W4297201515 cites W2597217516 @default.
• W4297201515 cites W2602132542 @default.
• W4297201515 cites W2607139442 @default.
• W4297201515 cites W2621919225 @default.
• W4297201515 cites W2622648624 @default.
• W4297201515 cites W2654300172 @default.
• W4297201515 cites W2755972205 @default.
• W4297201515 cites W2761341410 @default.
• W4297201515 cites W2765491891 @default.
• W4297201515 cites W2765502155 @default.
• W4297201515 cites W2769309750 @default.
• W4297201515 cites W2774392981 @default.
• W4297201515 cites W2790015075 @default.
• W4297201515 cites W2804511116 @default.
• W4297201515 cites W2807672736 @default.
• W4297201515 cites W2842271423 @default.
• W4297201515 cites W2885725913 @default.
• W4297201515 cites W2887418966 @default.
• W4297201515 cites W2889352094 @default.
• W4297201515 cites W2909017225 @default.
• W4297201515 cites W2913008332 @default.
• W4297201515 cites W2937704642 @default.
• W4297201515 cites W2955156969 @default.
• W4297201515 cites W2963154495 @default.
• W4297201515 cites W2970087176 @default.
• W4297201515 cites W2989689187 @default.
• W4297201515 cites W2991462688 @default.
• W4297201515 cites W2999659504 @default.
• W4297201515 cites W3000089361 @default.
• W4297201515 cites W3000202162 @default.
• W4297201515 cites W3007896475 @default.
• W4297201515 cites W3012616651 @default.
• W4297201515 cites W3012794431 @default.
• W4297201515 cites W3013711965 @default.
• W4297201515 cites W3014160396 @default.
• W4297201515 cites W3022179669 @default.
• W4297201515 cites W3092720153 @default.
• W4297201515 cites W3107459439 @default.
• W4297201515 cites W3140277041 @default.
• W4297201515 cites W3156706852 @default.
• W4297201515 cites W3173564302 @default.
• W4297201515 cites W3193297191 @default.
• W4297201515 cites W3211115056 @default.

• next