FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4297229182> ?p ?o ?g. }

• W4297229182 abstract "Consolidative allogeneic hematopoietic stem cells (allo-HSCs) after chimeric antigen receptor T cells (CAR-T) therapy is an emerging modality in hematologic malignancies. Knowledge about the success of allogeneic hematopoietic stem cell transplantation (allo-HSCT) after CAR-T therapy without a conditioning regimen is limited.We report a patient with relapsed/refractory (R/R) Ph+ B-cell acute lymphoblastic leukemia (ALL) who underwent anti-CD19 CAR-T immunotherapy. After 1 month of treatment, bone marrow hyperplasia remained reduced with no hematopoietic improvements. In line with this, allogeneic hematopoietic stem cells (HSCs) were extracted from an HLA-matched sibling donor and administered to the patient on day 33 after CAR-T cell therapy to support hematopoiesis. On day 40, the level of immature bone marrow lymphocytes was at 0% and minimal residual disease-negative, and the fusion gene BCR/ABL 190 was negative. Chimerism analysis showed full donor chimerism. Three months after CAR-T cells infusion, the patient was still in complete remission with full donor chimerism. However, decreased liver function with skin pigmentation and festering, indicative of acute graft versus host disease, was noted. The treatment was halted owing to financial reasons.We report the successful engraftment of allogeneic HSCs using CAR-T cell therapy as a conditioning regimen for R/R B-ALL patients." @default.
• W4297229182 created "2022-09-28" @default.
• W4297229182 creator A5000927257 @default.
• W4297229182 creator A5004139292 @default.
• W4297229182 creator A5013339942 @default.
• W4297229182 creator A5022954998 @default.
• W4297229182 creator A5026655079 @default.
• W4297229182 creator A5031142169 @default.
• W4297229182 creator A5031523854 @default.
• W4297229182 creator A5050450526 @default.
• W4297229182 creator A5052917034 @default.
• W4297229182 creator A5061810022 @default.
• W4297229182 creator A5074411641 @default.
• W4297229182 creator A5090241332 @default.
• W4297229182 date "2022-09-26" @default.
• W4297229182 modified "2023-09-29" @default.
• W4297229182 title "Case Report: Successful engraftment of allogeneic hematopoietic stem cells using CAR-T cell therapy as the conditioning regimen in R/R Ph+ B cell acute lymphoblastic leukemia" @default.
• W4297229182 cites W1491993932 @default.
• W4297229182 cites W1495360896 @default.
• W4297229182 cites W1555553634 @default.
• W4297229182 cites W1963522404 @default.
• W4297229182 cites W1974431455 @default.
• W4297229182 cites W1988623079 @default.
• W4297229182 cites W2047192675 @default.
• W4297229182 cites W2082708772 @default.
• W4297229182 cites W2099570622 @default.
• W4297229182 cites W2118796952 @default.
• W4297229182 cites W2129702476 @default.
• W4297229182 cites W2561777634 @default.
• W4297229182 cites W2896339322 @default.
• W4297229182 cites W2911504656 @default.
• W4297229182 cites W2916606137 @default.
• W4297229182 cites W2962839079 @default.
• W4297229182 cites W2973571741 @default.
• W4297229182 cites W2975959696 @default.
• W4297229182 cites W2985909236 @default.
• W4297229182 cites W2995728170 @default.
• W4297229182 cites W3095906001 @default.
• W4297229182 cites W3110503204 @default.
• W4297229182 cites W3112175219 @default.
• W4297229182 cites W4284897110 @default.
• W4297229182 doi "https://doi.org/10.3389/fimmu.2022.965932" @default.
• W4297229182 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/36225940" @default.
• W4297229182 hasPublicationYear "2022" @default.
• W4297229182 type Work @default.
• W4297229182 citedByCount "2" @default.
• W4297229182 countsByYear W42972291822022 @default.
• W4297229182 countsByYear W42972291822023 @default.
• W4297229182 crossrefType "journal-article" @default.
• W4297229182 hasAuthorship W4297229182A5000927257 @default.
• W4297229182 hasAuthorship W4297229182A5004139292 @default.
• W4297229182 hasAuthorship W4297229182A5013339942 @default.
• W4297229182 hasAuthorship W4297229182A5022954998 @default.
• W4297229182 hasAuthorship W4297229182A5026655079 @default.
• W4297229182 hasAuthorship W4297229182A5031142169 @default.
• W4297229182 hasAuthorship W4297229182A5031523854 @default.
• W4297229182 hasAuthorship W4297229182A5050450526 @default.
• W4297229182 hasAuthorship W4297229182A5052917034 @default.
• W4297229182 hasAuthorship W4297229182A5061810022 @default.
• W4297229182 hasAuthorship W4297229182A5074411641 @default.
• W4297229182 hasAuthorship W4297229182A5090241332 @default.
• W4297229182 hasBestOaLocation W42972291821 @default.
• W4297229182 hasConcept C109159458 @default.
• W4297229182 hasConcept C126322002 @default.
• W4297229182 hasConcept C143998085 @default.
• W4297229182 hasConcept C203014093 @default.
• W4297229182 hasConcept C2777408962 @default.
• W4297229182 hasConcept C2777701055 @default.
• W4297229182 hasConcept C2778461978 @default.
• W4297229182 hasConcept C2779823535 @default.
• W4297229182 hasConcept C2780007613 @default.
• W4297229182 hasConcept C2781107101 @default.
• W4297229182 hasConcept C28328180 @default.
• W4297229182 hasConcept C2909962599 @default.
• W4297229182 hasConcept C2911091166 @default.
• W4297229182 hasConcept C3875195 @default.
• W4297229182 hasConcept C502942594 @default.
• W4297229182 hasConcept C54355233 @default.
• W4297229182 hasConcept C71924100 @default.
• W4297229182 hasConcept C86803240 @default.
• W4297229182 hasConcept C8891405 @default.
• W4297229182 hasConceptScore W4297229182C109159458 @default.
• W4297229182 hasConceptScore W4297229182C126322002 @default.
• W4297229182 hasConceptScore W4297229182C143998085 @default.
• W4297229182 hasConceptScore W4297229182C203014093 @default.
• W4297229182 hasConceptScore W4297229182C2777408962 @default.
• W4297229182 hasConceptScore W4297229182C2777701055 @default.
• W4297229182 hasConceptScore W4297229182C2778461978 @default.
• W4297229182 hasConceptScore W4297229182C2779823535 @default.
• W4297229182 hasConceptScore W4297229182C2780007613 @default.
• W4297229182 hasConceptScore W4297229182C2781107101 @default.
• W4297229182 hasConceptScore W4297229182C28328180 @default.
• W4297229182 hasConceptScore W4297229182C2909962599 @default.
• W4297229182 hasConceptScore W4297229182C2911091166 @default.
• W4297229182 hasConceptScore W4297229182C3875195 @default.
• W4297229182 hasConceptScore W4297229182C502942594 @default.
• W4297229182 hasConceptScore W4297229182C54355233 @default.
• W4297229182 hasConceptScore W4297229182C71924100 @default.
• W4297229182 hasConceptScore W4297229182C86803240 @default.
• W4297229182 hasConceptScore W4297229182C8891405 @default.

• next