FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4297229831> ?p ?o ?g. }

• W4297229831 abstract "Abstract A joint contains many different tissues that can exhibit pathological changes, providing many potential targets for treatment. Researchers are increasingly suggesting that osteoarthritis (OA) comprises several phenotypes or subpopulations. Consequently, a treatment for OA that targets only one pathophysiologic abnormality is unlikely to be similarly efficacious in preventing or delaying the progression of all the different phenotypes of structural OA. Five structural phenotypes have been proposed, namely the inflammatory, meniscus-cartilage, subchondral bone, and atrophic and hypertrophic phenotypes. The inflammatory phenotype is characterized by marked synovitis and/or joint effusion, while the meniscus-cartilage phenotype exhibits severe meniscal and cartilage damage. Large bone marrow lesions characterize the subchondral bone phenotype. The hypertrophic and atrophic OA phenotype are defined based on the presence large osteophytes or absence of any osteophytes, respectively, in the presence of concomitant cartilage damage. Limitations of the concept of structural phenotyping are that they are not mutually exclusive and that more than one phenotype may be present. It must be acknowledged that a wide range of views exist on how best to operationalize the concept of structural OA phenotypes and that the concept of structural phenotypic characterization is still in its infancy. Structural phenotypic stratification, however, may result in more targeted trial populations with successful outcomes and practitioners need to be aware of the heterogeneity of the disease to personalize their treatment recommendations for an individual patient. Radiologists should be able to define a joint at risk for progression based on the predominant phenotype present at different disease stages." @default.
• W4297229831 created "2022-09-28" @default.
• W4297229831 creator A5000747453 @default.
• W4297229831 creator A5002622252 @default.
• W4297229831 creator A5040027621 @default.
• W4297229831 creator A5057463669 @default.
• W4297229831 creator A5069018938 @default.
• W4297229831 creator A5080921373 @default.
• W4297229831 creator A5089912492 @default.
• W4297229831 date "2022-09-26" @default.
• W4297229831 modified "2023-10-03" @default.
• W4297229831 title "Structural phenotypes of knee osteoarthritis: potential clinical and research relevance" @default.
• W4297229831 cites W1769995272 @default.
• W4297229831 cites W1968900840 @default.
• W4297229831 cites W1974759500 @default.
• W4297229831 cites W1978598945 @default.
• W4297229831 cites W1978864283 @default.
• W4297229831 cites W1981759123 @default.
• W4297229831 cites W1982917662 @default.
• W4297229831 cites W1992301741 @default.
• W4297229831 cites W1992763054 @default.
• W4297229831 cites W1993990835 @default.
• W4297229831 cites W1994206642 @default.
• W4297229831 cites W1997637714 @default.
• W4297229831 cites W2002999171 @default.
• W4297229831 cites W2005381591 @default.
• W4297229831 cites W2008748579 @default.
• W4297229831 cites W2009524387 @default.
• W4297229831 cites W2009549130 @default.
• W4297229831 cites W2011227409 @default.
• W4297229831 cites W2026123588 @default.
• W4297229831 cites W2027831505 @default.
• W4297229831 cites W2027970609 @default.
• W4297229831 cites W2030343312 @default.
• W4297229831 cites W2033544061 @default.
• W4297229831 cites W2037197894 @default.
• W4297229831 cites W2044953211 @default.
• W4297229831 cites W2052204542 @default.
• W4297229831 cites W2057531961 @default.
• W4297229831 cites W2061782863 @default.
• W4297229831 cites W2065485575 @default.
• W4297229831 cites W2071292955 @default.
• W4297229831 cites W2084597931 @default.
• W4297229831 cites W2088536726 @default.
• W4297229831 cites W2098270713 @default.
• W4297229831 cites W2102838907 @default.
• W4297229831 cites W2104005171 @default.
• W4297229831 cites W2106055152 @default.
• W4297229831 cites W2106486836 @default.
• W4297229831 cites W2109228592 @default.
• W4297229831 cites W2112475645 @default.
• W4297229831 cites W2118378925 @default.
• W4297229831 cites W2118903184 @default.
• W4297229831 cites W2119479015 @default.
• W4297229831 cites W2120486558 @default.
• W4297229831 cites W2121625978 @default.
• W4297229831 cites W2129233553 @default.
• W4297229831 cites W2131885429 @default.
• W4297229831 cites W2137996072 @default.
• W4297229831 cites W2139736838 @default.
• W4297229831 cites W2140215285 @default.
• W4297229831 cites W2146327854 @default.
• W4297229831 cites W2151189496 @default.
• W4297229831 cites W2164948946 @default.
• W4297229831 cites W2314589545 @default.
• W4297229831 cites W2461522900 @default.
• W4297229831 cites W2466427102 @default.
• W4297229831 cites W2481203471 @default.
• W4297229831 cites W2531292545 @default.
• W4297229831 cites W2555182538 @default.
• W4297229831 cites W2623056179 @default.
• W4297229831 cites W2745599707 @default.
• W4297229831 cites W2802856407 @default.
• W4297229831 cites W2892390398 @default.
• W4297229831 cites W2907978839 @default.
• W4297229831 cites W2972323401 @default.
• W4297229831 cites W2980134306 @default.
• W4297229831 cites W2983586462 @default.
• W4297229831 cites W3000036091 @default.
• W4297229831 cites W3011447062 @default.
• W4297229831 cites W3026025799 @default.
• W4297229831 cites W4224312563 @default.
• W4297229831 cites W4281750458 @default.
• W4297229831 cites W4285745043 @default.
• W4297229831 doi "https://doi.org/10.1007/s00256-022-04191-6" @default.
• W4297229831 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/36161341" @default.
• W4297229831 hasPublicationYear "2022" @default.
• W4297229831 type Work @default.
• W4297229831 citedByCount "8" @default.
• W4297229831 countsByYear W42972298312022 @default.
• W4297229831 countsByYear W42972298312023 @default.
• W4297229831 crossrefType "journal-article" @default.
• W4297229831 hasAuthorship W4297229831A5000747453 @default.
• W4297229831 hasAuthorship W4297229831A5002622252 @default.
• W4297229831 hasAuthorship W4297229831A5040027621 @default.
• W4297229831 hasAuthorship W4297229831A5057463669 @default.
• W4297229831 hasAuthorship W4297229831A5069018938 @default.
• W4297229831 hasAuthorship W4297229831A5080921373 @default.
• W4297229831 hasAuthorship W4297229831A5089912492 @default.
• W4297229831 hasBestOaLocation W42972298311 @default.

• next