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• W4297231449 abstract "• Novel Ag-Cyanamide derivatives had been synthesis, characterized and applied as antibiotic. ○ Different approach was used to prepare 4-cyanamide benzoic acid, two its Ag-coordination polymers. • Ag-cyanamide coordination polymers of 4-cyanamide benzoic acid were synthesized using a facile method. • Toxicity and antibacterial properties of all synthesized materials assessed through MTT assay, Macrodilution and agar well diffusion plates (against Gram positive and Gram negative bacteria), respectively. • Ag-cyanamide coordination polymers of 4-cyanamide benzoic acid have excellent performance especially against Gram positive bacteria. 4-CyBA (4-Cyanamide Benzoic Acid) and two novel Ag-coordination polymers of 4-CyBA; Ag-A-4-CyBA and Ag-4-CyBA have been synthesized. In the current work, 4-CyBA was prepared throughout a different methodology in comparison with the other ways which previously had been applied to synthesize this organic material. The nature and structural effects of 4-CyBA, Ag-A-4-CyBA and Ag-4-CyBA were studied with regard to the physical and biological features of them. Ag-4-CyBA has baculiform, and Ag-A-4-CyBA has prickle-on-spike form and the surface areas of them were found 4.779 m 2 /g and 30.851 m 2 /g, respectively. The antibacterial and toxicity activities of these materials were moreover assessed. The results exhibited that Ag-A-4-CyBA displayed the best antibacterial activity special against Gram-positive type ( S. aureus ) even more than reference drug tetracycline. Furthermore, the toxic potencies of these materials were in the order of Ag-A-4-CyBA > 4-CyBA > Ag-4-CyBA against HT29 and A549 cancerous cell-lines, but for AGS, the sequences of toxicity were 4-CyBA > Ag-4-CyBA > Ag-A-4-CyBA as the results of MTT-tests. Again, Ag-A-4-CyBA has the most toxic activity against HT-29 and A549 carcinomatous cell lines among these three compound." @default.
• W4297231449 created "2022-09-28" @default.
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• W4297231449 date "2023-02-01" @default.
• W4297231449 modified "2023-09-24" @default.
• W4297231449 title "Facile synthesis of two novel micro Ag-Cyanamide derivatives and different approach of 4-CyBA preparation, characterization and in vitro evaluations (anti-bacterial and toxicity properties)" @default.
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• W4297231449 doi "https://doi.org/10.1016/j.molstruc.2022.134218" @default.
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