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• W4297235874 abstract "Abstract Anti-neuronal autoantibodies can be transplacentally transferred during pregnancy and may cause detrimental effects on fetal development. It is unclear whether autoantibodies against synapsin-I, one of the most abundant synaptic proteins, are associated with developmental abnormalities in humans. We prospectively recruited a cohort of 263 pregnant women and detected serum synapsin-I IgG autoantibodies in 13.3%. Seropositivity was strongly associated with abnormalities of fetal development including intrauterine growth retardation. This finding indicates that these autoantibodies may be clinically useful developmental biomarkers and/or even directly participate in the disease process, thus being amenable to antibody-targeting interventional strategies in the future." @default.
• W4297235874 created "2022-09-28" @default.
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• W4297235874 date "2022-09-25" @default.
• W4297235874 modified "2023-10-16" @default.
• W4297235874 title "Synapsin autoantibodies during pregnancy are associated with fetal abnormalities" @default.
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• W4297235874 doi "https://doi.org/10.1101/2022.09.23.22280284" @default.
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