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• W4297236435 abstract "Cystic fibrosis (CF) airway epithelium shows alterations in repair following damage. In vitro studies showed that lumacaftor/ivacaftor (Orkambi) may favor airway epithelial integrity in CF patients. Our aim was to evaluate the effect of the novel triple combination elexacaftor/tezacaftor/ivacaftor (ETI) on wound repair in CF airway epithelial cells.A tip-based scratch assay was employed to study wound repair in monolayers of CFBE14o- cells overexpressing the F508del mutation. ETI was added during wound repair.ETI efficiently rescued CFTR F508del maturation and activity, accelerated wound closure and increased wound healing rates of the injured CF cell monolayers.The triple corrector/potentiator combination ETI shows promise in ameliorating wound healing of the airway epithelium in F508del patients." @default.
• W4297236435 created "2022-09-28" @default.
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• W4297236435 date "2022-09-25" @default.
• W4297236435 modified "2023-09-30" @default.
• W4297236435 title "Elexacaftor/Tezacaftor/Ivacaftor Accelerates Wound Repair in Cystic Fibrosis Airway Epithelium" @default.
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• W4297236435 doi "https://doi.org/10.3390/jpm12101577" @default.
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