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- W4297236915 abstract "Background: Biological aging may be a robust biomarker of dementia or cognitive performance. This systematic review synthesized the evidence for an association between epigenetic aging and dementia, mild cognitive impairment and cognitive function. Methods: A systematic search was conducted according to Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines. Results: 30 eligible articles were included. There was no strong evidence that accelerated epigenetic aging was associated with dementia/mild cognitive impairment (n = 7). There was some evidence of an association with poorer cognition (n = 20), particularly with GrimAge acceleration, but this was inconsistent and varied across cognitive domains. A meta-analysis was not performed due to high study heterogeneity. Conclusion: There is insufficient evidence to indicate that current epigenetic aging clocks can be clinically useful biomarkers of dementia or cognitive aging." @default.
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- W4297236915 date "2022-09-01" @default.
- W4297236915 modified "2023-10-12" @default.
- W4297236915 title "Epigenetic aging as a biomarker of dementia and related outcomes: a systematic review" @default.
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- W4297236915 doi "https://doi.org/10.2217/epi-2022-0209" @default.
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