FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4297237449> ?p ?o ?g. }

• W4297237449 abstract "Severe hearing loss or deafness is often caused by cochlear hair cell loss and can be mitigated by a cochlear implant (CI). CIs target the auditory nerve, consisting of spiral ganglion cells (SGCs), which degenerate gradually, following hair cell loss. In animal models, it has been established that treatment with the neurotrophins brain-derived neurotrophic factor (BDNF) and neurotrophin-3 (NT-3) reduce SGC degeneration. In this study, we aimed to investigate whether treatment with both BDNF and NT-3 (Cocktail) is superior to treatment with each neurotrophin separately regarding cell preservation and neural responsiveness to electrical stimulation. To this end, deafened guinea pigs received neurotrophic treatment in their right ear via a gelatin sponge on the perforated round window membrane, followed by cochlear implantation 4 weeks later in the same ear for electrophysiological recordings to various stimulation paradigms. Normal-hearing and deafened untreated guinea pigs were included as positive and negative controls, respectively. Substantial SGC loss occurred in all deafened animals. Each of the neurotrophic treatments led to enhanced SGC survival mainly in the basal turn of the cochlea, gradually decreasing toward the apex. The Cocktail treatment resulted in the highest SGC survival in the treated ear, followed by BDNF, with the least protection of SGCs following NT-3 treatment. Survival of the SGC's peripheral processes (PPs) followed the same trend in response to the treatment. However, survival of SGCs and PPs in the contralateral untreated ears was also highest in the Cocktail group. Consequently, analysis of the ratio between the treated and untreated ears showed that the BDNF group, which showed low SGC survival in the untreated ear, had the highest relative SGC survival of the three neurotrophin-treated groups. Neurotrophic treatment had positive effects in part of the electrically evoked compound action-potential recording paradigms. These effects were only observed for the BDNF or Cocktail treatment. We conclude that treatment with either BDNF or a cocktail of BDNF and NT-3 is preferred to NT-3 alone. Furthermore, since the Cocktail treatment resulted in better electrophysiological responsiveness and overall higher SGC survival than BDNF alone, we are inclined to recommend the Cocktail treatment rather than BDNF alone." @default.
• W4297237449 created "2022-09-28" @default.
• W4297237449 creator A5018005465 @default.
• W4297237449 creator A5064856966 @default.
• W4297237449 creator A5074556968 @default.
• W4297237449 creator A5081540430 @default.
• W4297237449 date "2022-09-26" @default.
• W4297237449 modified "2023-10-13" @default.
• W4297237449 title "Combined brain-derived neurotrophic factor and neurotrophin-3 treatment is preferred over either one separately in the preservation of the auditory nerve in deafened guinea pigs" @default.
• W4297237449 cites W1668536118 @default.
• W4297237449 cites W1859430127 @default.
• W4297237449 cites W1964000981 @default.
• W4297237449 cites W1964248735 @default.
• W4297237449 cites W1985643560 @default.
• W4297237449 cites W1990443586 @default.
• W4297237449 cites W1992695138 @default.
• W4297237449 cites W1993099172 @default.
• W4297237449 cites W1995261715 @default.
• W4297237449 cites W2001047327 @default.
• W4297237449 cites W2002512650 @default.
• W4297237449 cites W2005619612 @default.
• W4297237449 cites W2006904223 @default.
• W4297237449 cites W2008803709 @default.
• W4297237449 cites W2014222020 @default.
• W4297237449 cites W2015191826 @default.
• W4297237449 cites W2019255057 @default.
• W4297237449 cites W2020325475 @default.
• W4297237449 cites W2034040572 @default.
• W4297237449 cites W2034331964 @default.
• W4297237449 cites W2035266661 @default.
• W4297237449 cites W2043784071 @default.
• W4297237449 cites W2044015089 @default.
• W4297237449 cites W2046610720 @default.
• W4297237449 cites W2049307047 @default.
• W4297237449 cites W2058359348 @default.
• W4297237449 cites W2061063067 @default.
• W4297237449 cites W2069855517 @default.
• W4297237449 cites W2070021689 @default.
• W4297237449 cites W2076669076 @default.
• W4297237449 cites W2088288879 @default.
• W4297237449 cites W2088919858 @default.
• W4297237449 cites W2098537456 @default.
• W4297237449 cites W2115595764 @default.
• W4297237449 cites W2122962129 @default.
• W4297237449 cites W2130323061 @default.
• W4297237449 cites W2143374954 @default.
• W4297237449 cites W2152933007 @default.
• W4297237449 cites W2171073672 @default.
• W4297237449 cites W2207298570 @default.
• W4297237449 cites W2326040854 @default.
• W4297237449 cites W2471308520 @default.
• W4297237449 cites W2474190992 @default.
• W4297237449 cites W2520285939 @default.
• W4297237449 cites W2530399087 @default.
• W4297237449 cites W2546135632 @default.
• W4297237449 cites W2570803777 @default.
• W4297237449 cites W2756019535 @default.
• W4297237449 cites W2916617192 @default.
• W4297237449 cites W2949441841 @default.
• W4297237449 cites W2978212006 @default.
• W4297237449 cites W3008339469 @default.
• W4297237449 cites W3094130093 @default.
• W4297237449 cites W3095887906 @default.
• W4297237449 cites W3097105875 @default.
• W4297237449 cites W3107714301 @default.
• W4297237449 cites W3116219014 @default.
• W4297237449 cites W3213729614 @default.
• W4297237449 cites W4200243962 @default.
• W4297237449 doi "https://doi.org/10.3389/fnmol.2022.935111" @default.
• W4297237449 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/36226314" @default.
• W4297237449 hasPublicationYear "2022" @default.
• W4297237449 type Work @default.
• W4297237449 citedByCount "3" @default.
• W4297237449 countsByYear W42972374492023 @default.
• W4297237449 crossrefType "journal-article" @default.
• W4297237449 hasAuthorship W4297237449A5018005465 @default.
• W4297237449 hasAuthorship W4297237449A5064856966 @default.
• W4297237449 hasAuthorship W4297237449A5074556968 @default.
• W4297237449 hasAuthorship W4297237449A5081540430 @default.
• W4297237449 hasBestOaLocation W42972374491 @default.
• W4297237449 hasConcept C126322002 @default.
• W4297237449 hasConcept C160539049 @default.
• W4297237449 hasConcept C170493617 @default.
• W4297237449 hasConcept C24998067 @default.
• W4297237449 hasConcept C2778585322 @default.
• W4297237449 hasConcept C2778790584 @default.
• W4297237449 hasConcept C2779152698 @default.
• W4297237449 hasConcept C2779456298 @default.
• W4297237449 hasConcept C2780130748 @default.
• W4297237449 hasConcept C2780493683 @default.
• W4297237449 hasConcept C2780757810 @default.
• W4297237449 hasConcept C548259974 @default.
• W4297237449 hasConcept C71924100 @default.
• W4297237449 hasConcept C92020748 @default.
• W4297237449 hasConceptScore W4297237449C126322002 @default.
• W4297237449 hasConceptScore W4297237449C160539049 @default.
• W4297237449 hasConceptScore W4297237449C170493617 @default.
• W4297237449 hasConceptScore W4297237449C24998067 @default.
• W4297237449 hasConceptScore W4297237449C2778585322 @default.
• W4297237449 hasConceptScore W4297237449C2778790584 @default.

• next