FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4297238087> ?p ?o ?g. }

• W4297238087 abstract "Abstract Aims The Blood-Brain Barrier (BBB) is a filter for most medications and blocks their passage into the brain. More effective drug delivery strategies are urgently needed to transport medications into the brain. This study investigated the biodistribution of thymoquinone (TQ) and the effect on enzymatic and non-enzymatic oxidative stress indicators in different brain regions, either in free form or incorporated into nanocarriers as mesoporous silica nanoparticles (MSNs). Lipid bilayer-coated MSNs. Materials and methods MSNs and LB-MSNs were synthesized and characterized using a transmission electron microscope and dynamic light scattering to determine the particle size and zeta potential. TQ encapsulation efficiency and TQ's release profile from LB-MSNs were also examined. The impact of loading LB-MSNs with TQ-on-TQ delivery to different brain areas was examined using chromatographic measurement. Furthermore, nitric oxide, malondialdehyde (MDA), reduced glutathione, and catalase were evaluated as oxidant and antioxidant stress biomarkers. Key findings The LB-MSNs formulation successfully transported TQ to several areas of the brain, liver, and kidney, revealing a considerable increase in TQ delivery in the thalamus (81.74%) compared with that in the free TQ group and a considerable reduction in the cortex (−44%). The LB-MSNs formulation had no significant effect on TQ delivery in the cerebellum, striatum, liver, and kidney. Significance TQ was redistributed in different brain areas after being encapsulated in LB-MSNs, indicating that LB-MSNs have the potential to be developed as a drug delivery system for selective clinical application of specific brain regions. Conclusions LB-MSNs are capable nanoplatforms that can be used to target medications precisely to specific brain regions" @default.
• W4297238087 created "2022-09-28" @default.
• W4297238087 creator A5001295257 @default.
• W4297238087 creator A5001717253 @default.
• W4297238087 creator A5005134801 @default.
• W4297238087 creator A5009694496 @default.
• W4297238087 creator A5013088532 @default.
• W4297238087 creator A5055198948 @default.
• W4297238087 creator A5067316942 @default.
• W4297238087 creator A5074262414 @default.
• W4297238087 creator A5083473977 @default.
• W4297238087 creator A5090720579 @default.
• W4297238087 date "2022-09-26" @default.
• W4297238087 modified "2023-10-07" @default.
• W4297238087 title "Novel lipid-coated mesoporous silica nanoparticles loaded with thymoquinone formulation to increase its bioavailability in the brain and organs of Wistar rats" @default.
• W4297238087 cites W1534776779 @default.
• W4297238087 cites W1861458934 @default.
• W4297238087 cites W1881951590 @default.
• W4297238087 cites W191793640 @default.
• W4297238087 cites W1965724633 @default.
• W4297238087 cites W1992598609 @default.
• W4297238087 cites W1995220749 @default.
• W4297238087 cites W1999060596 @default.
• W4297238087 cites W2002704831 @default.
• W4297238087 cites W2006370393 @default.
• W4297238087 cites W2022149076 @default.
• W4297238087 cites W2040501773 @default.
• W4297238087 cites W2055870112 @default.
• W4297238087 cites W2059110340 @default.
• W4297238087 cites W2071215562 @default.
• W4297238087 cites W2111826228 @default.
• W4297238087 cites W2112487069 @default.
• W4297238087 cites W2145133103 @default.
• W4297238087 cites W2156767606 @default.
• W4297238087 cites W2302273425 @default.
• W4297238087 cites W2337236590 @default.
• W4297238087 cites W2395326132 @default.
• W4297238087 cites W2513498847 @default.
• W4297238087 cites W2604121576 @default.
• W4297238087 cites W2606099128 @default.
• W4297238087 cites W2620551119 @default.
• W4297238087 cites W2735467308 @default.
• W4297238087 cites W2758013425 @default.
• W4297238087 cites W2762960400 @default.
• W4297238087 cites W2779379878 @default.
• W4297238087 cites W2791695579 @default.
• W4297238087 cites W2795428083 @default.
• W4297238087 cites W2800956599 @default.
• W4297238087 cites W2884014185 @default.
• W4297238087 cites W2887939261 @default.
• W4297238087 cites W2901377967 @default.
• W4297238087 cites W2908006336 @default.
• W4297238087 cites W2919063349 @default.
• W4297238087 cites W2959512054 @default.
• W4297238087 cites W2980256771 @default.
• W4297238087 cites W3023255929 @default.
• W4297238087 cites W3023789730 @default.
• W4297238087 cites W3043846758 @default.
• W4297238087 cites W3095194218 @default.
• W4297238087 cites W3123504595 @default.
• W4297238087 cites W3150396126 @default.
• W4297238087 cites W3184465565 @default.
• W4297238087 doi "https://doi.org/10.1186/s40360-022-00616-z" @default.
• W4297238087 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/36163187" @default.
• W4297238087 hasPublicationYear "2022" @default.
• W4297238087 type Work @default.
• W4297238087 citedByCount "1" @default.
• W4297238087 countsByYear W42972380872023 @default.
• W4297238087 crossrefType "journal-article" @default.
• W4297238087 hasAuthorship W4297238087A5001295257 @default.
• W4297238087 hasAuthorship W4297238087A5001717253 @default.
• W4297238087 hasAuthorship W4297238087A5005134801 @default.
• W4297238087 hasAuthorship W4297238087A5009694496 @default.
• W4297238087 hasAuthorship W4297238087A5013088532 @default.
• W4297238087 hasAuthorship W4297238087A5055198948 @default.
• W4297238087 hasAuthorship W4297238087A5067316942 @default.
• W4297238087 hasAuthorship W4297238087A5074262414 @default.
• W4297238087 hasAuthorship W4297238087A5083473977 @default.
• W4297238087 hasAuthorship W4297238087A5090720579 @default.
• W4297238087 hasBestOaLocation W42972380871 @default.
• W4297238087 hasConcept C12554922 @default.
• W4297238087 hasConcept C126322002 @default.
• W4297238087 hasConcept C155672457 @default.
• W4297238087 hasConcept C161790260 @default.
• W4297238087 hasConcept C171250308 @default.
• W4297238087 hasConcept C178790620 @default.
• W4297238087 hasConcept C18150654 @default.
• W4297238087 hasConcept C185592680 @default.
• W4297238087 hasConcept C192562407 @default.
• W4297238087 hasConcept C202751555 @default.
• W4297238087 hasConcept C2776151105 @default.
• W4297238087 hasConcept C2777496208 @default.
• W4297238087 hasConcept C2777807558 @default.
• W4297238087 hasConcept C2778004101 @default.
• W4297238087 hasConcept C2778402981 @default.
• W4297238087 hasConcept C2779034068 @default.
• W4297238087 hasConcept C2779820397 @default.
• W4297238087 hasConcept C2780035454 @default.
• W4297238087 hasConcept C529278444 @default.
• W4297238087 hasConcept C55493867 @default.

• next