Matches in SemOpenAlex for { <https://semopenalex.org/work/W4297238864> ?p ?o ?g. }
- W4297238864 abstract "The neural crest (NC) is an important multipotent embryonic cell population and its impaired specification leads to various developmental defects, often in an anteroposterior (A-P) axial level-specific manner. The mechanisms underlying the correct A-P regionalisation of human NC cells remain elusive. Recent studies have indicated that trunk NC cells, the presumed precursors of childhood tumour neuroblastoma, are derived from neuromesodermal-potent progenitors of the postcranial body. Here we employ human embryonic stem cell differentiation to define how neuromesodermal progenitor (NMP)-derived NC cells acquire a posterior axial identity. We show that TBXT, a pro-mesodermal transcription factor, mediates early posterior NC/spinal cord regionalisation together with WNT signalling effectors. This occurs by TBXT-driven chromatin remodelling via its binding in key enhancers within HOX gene clusters and other posterior regulator-associated loci. This initial posteriorisation event is succeeded by a second phase of trunk HOX gene control that marks the differentiation of NMPs toward their TBXT-negative NC/spinal cord derivatives and relies predominantly on FGF signalling. Our work reveals a previously unknown role of TBXT in influencing posterior NC fate and points to the existence of temporally discrete, cell type-dependent modes of posterior axial identity control." @default.
- W4297238864 created "2022-09-28" @default.
- W4297238864 creator A5013685532 @default.
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- W4297238864 creator A5083138771 @default.
- W4297238864 date "2022-09-26" @default.
- W4297238864 modified "2023-10-18" @default.
- W4297238864 title "Early anteroposterior regionalisation of human neural crest is shaped by a pro-mesodermal factor" @default.
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