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- W4297239013 abstract "Abstract Gluten related‐disorders have a prevalence of 1–5 % worldwide triggered by the ingestion of gluten proteins in wheat, rye, barley, and some oats. In wheat gluten, the most studied protein is gliadin, whose immunodominant 33‐mer amino acid fragment remains after digestive proteolysis and accumulates in the gut mucosa. Here, we report the formation of 33‐mer thin‐plate superstructures using intrinsic tyrosine (Tyr) steady‐state fluorescence anisotropy and cryo‐TEM in combination with water tension measurements. Furthermore, we showed that fluorescence decay measurements of 33‐mer intrinsic fluorophore Tyr provided information on the early stages of the formation of the thin‐plate structures. Finally, conformational analysis of Tyr residues using minimalist models by molecular dynamic simulations (MD) demonstrated that changes in Tyr rotamer states depend on the oligomerization stage. Our findings further advance the understanding of the formation of the 33‐mer gliadin peptide superstructures and their relation to health and disease." @default.
- W4297239013 created "2022-09-28" @default.
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- W4297239013 date "2022-10-18" @default.
- W4297239013 modified "2023-10-18" @default.
- W4297239013 title "Thin‐Plate Superstructures of the Immunogenic 33‐mer Gliadin Peptide" @default.
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- W4297239013 doi "https://doi.org/10.1002/cbic.202200552" @default.
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