FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4297239114> ?p ?o ?g. }

• W4297239114 endingPage "486" @default.
• W4297239114 startingPage "471" @default.
• W4297239114 abstract "The interferon-γ (IFN-γ) release assay (IGRA) is widely used to diagnose tuberculosis (TB) caused by Mycobacterium tuberculosis (Mtb). However, indeterminate IGRA results due to high Nil or low PHA responses limit its clinical utility. We developed a novel assay using CD69 flow cytometry (FC) to complement IGRA.CD69 FC measures the surface CD69 expression on T cells prior to centrifugation to harvest the plasma for IGRA. T cell responses against Mtb antigen 1 (Ag1) or Ag2 were measured using three-color FC (CD3, CD4, and CD69) in TB (n = 140) and non-TB groups (n = 117). The cutoff values of Δ%CD69bright cells (stimulated minus unstimulated) for CD4+ and CD4- T cells were established based on healthy individuals (n = 63). The assay performances of CD69 FC and IGRA were compared.In subjects with determinate IGRA results (positive or negative; n = 216), the diagnostic accuracies of CD69 FC (90.3%) and IGRA (87.0%) were not significantly different (p = 0.31). For indeterminate IGRA results (n = 40), CD69 FC attained a diagnostic accuracy of 92.5%. The CD4+ /CD4- ratio within CD69bright T cells measured by CD69 FC was significantly higher (p < 0.05) in the active TB group (6.39 ± 132.05; n = 72) than in other CD69 FC-positive subjects (2.84 ± 15.36; n = 63) (p < 0.05), whereas CD8 responses expected by IGRA (difference of IFN-γ levels between Mtb Ag tubes) did not differ significantly (0.00 ± 9.18 and 0.00 ± 4.25, respectively, IU/ml; p = 0.58).We demonstrated the potential of CD69 FC as a simple, rapid assay for clarifying indeterminate IGRA results and identifying active TB. With further improvements, CD69 FC may complement the IGRA to enhance TB risk stratification in the routine diagnostic workup." @default.
• W4297239114 created "2022-09-28" @default.
• W4297239114 creator A5003033255 @default.
• W4297239114 creator A5011748942 @default.
• W4297239114 creator A5012222130 @default.
• W4297239114 creator A5083528631 @default.
• W4297239114 date "2022-09-26" @default.
• W4297239114 modified "2023-09-30" @default.
• W4297239114 title "<scp>CD69</scp> flow cytometry to complement interferon‐<i>γ</i> release assay for active tuberculosis" @default.
• W4297239114 cites W1818285885 @default.
• W4297239114 cites W1909108525 @default.
• W4297239114 cites W1965668880 @default.
• W4297239114 cites W1975159750 @default.
• W4297239114 cites W1980511763 @default.
• W4297239114 cites W1981131122 @default.
• W4297239114 cites W2026944105 @default.
• W4297239114 cites W2080174285 @default.
• W4297239114 cites W2103095153 @default.
• W4297239114 cites W2110589504 @default.
• W4297239114 cites W2113620330 @default.
• W4297239114 cites W2125136485 @default.
• W4297239114 cites W2133562534 @default.
• W4297239114 cites W2157342679 @default.
• W4297239114 cites W2165536523 @default.
• W4297239114 cites W2518225469 @default.
• W4297239114 cites W2559832962 @default.
• W4297239114 cites W2610932550 @default.
• W4297239114 cites W2614832311 @default.
• W4297239114 cites W2726051407 @default.
• W4297239114 cites W2744206105 @default.
• W4297239114 cites W2767073710 @default.
• W4297239114 cites W2769173460 @default.
• W4297239114 cites W2885005690 @default.
• W4297239114 cites W2911092243 @default.
• W4297239114 cites W2912724446 @default.
• W4297239114 cites W2946529671 @default.
• W4297239114 cites W2982328930 @default.
• W4297239114 cites W3036178535 @default.
• W4297239114 cites W3047719667 @default.
• W4297239114 cites W3094523597 @default.
• W4297239114 cites W3166784312 @default.
• W4297239114 cites W3197000790 @default.
• W4297239114 cites W3215604614 @default.
• W4297239114 cites W4200431150 @default.
• W4297239114 doi "https://doi.org/10.1002/cyto.b.22093" @default.
• W4297239114 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/36161692" @default.
• W4297239114 hasPublicationYear "2022" @default.
• W4297239114 type Work @default.
• W4297239114 citedByCount "3" @default.
• W4297239114 countsByYear W42972391142023 @default.
• W4297239114 crossrefType "journal-article" @default.
• W4297239114 hasAuthorship W4297239114A5003033255 @default.
• W4297239114 hasAuthorship W4297239114A5011748942 @default.
• W4297239114 hasAuthorship W4297239114A5012222130 @default.
• W4297239114 hasAuthorship W4297239114A5083528631 @default.
• W4297239114 hasConcept C114684123 @default.
• W4297239114 hasConcept C142724271 @default.
• W4297239114 hasConcept C153911025 @default.
• W4297239114 hasConcept C167672396 @default.
• W4297239114 hasConcept C176324957 @default.
• W4297239114 hasConcept C203014093 @default.
• W4297239114 hasConcept C2776090121 @default.
• W4297239114 hasConcept C2777975735 @default.
• W4297239114 hasConcept C2780841837 @default.
• W4297239114 hasConcept C2781069245 @default.
• W4297239114 hasConcept C553184892 @default.
• W4297239114 hasConcept C71924100 @default.
• W4297239114 hasConcept C79484868 @default.
• W4297239114 hasConcept C86803240 @default.
• W4297239114 hasConcept C8891405 @default.
• W4297239114 hasConceptScore W4297239114C114684123 @default.
• W4297239114 hasConceptScore W4297239114C142724271 @default.
• W4297239114 hasConceptScore W4297239114C153911025 @default.
• W4297239114 hasConceptScore W4297239114C167672396 @default.
• W4297239114 hasConceptScore W4297239114C176324957 @default.
• W4297239114 hasConceptScore W4297239114C203014093 @default.
• W4297239114 hasConceptScore W4297239114C2776090121 @default.
• W4297239114 hasConceptScore W4297239114C2777975735 @default.
• W4297239114 hasConceptScore W4297239114C2780841837 @default.
• W4297239114 hasConceptScore W4297239114C2781069245 @default.
• W4297239114 hasConceptScore W4297239114C553184892 @default.
• W4297239114 hasConceptScore W4297239114C71924100 @default.
• W4297239114 hasConceptScore W4297239114C79484868 @default.
• W4297239114 hasConceptScore W4297239114C86803240 @default.
• W4297239114 hasConceptScore W4297239114C8891405 @default.
• W4297239114 hasIssue "6" @default.
• W4297239114 hasLocation W42972391141 @default.
• W4297239114 hasLocation W42972391142 @default.
• W4297239114 hasOpenAccess W4297239114 @default.
• W4297239114 hasPrimaryLocation W42972391141 @default.
• W4297239114 hasRelatedWork W2103095153 @default.
• W4297239114 hasRelatedWork W2103863744 @default.
• W4297239114 hasRelatedWork W2171627501 @default.
• W4297239114 hasRelatedWork W2349894740 @default.
• W4297239114 hasRelatedWork W2355095363 @default.
• W4297239114 hasRelatedWork W2761385502 @default.
• W4297239114 hasRelatedWork W2788398649 @default.
• W4297239114 hasRelatedWork W3028987687 @default.

• next